In this paper we use the conventional quantum hydrodynamics (QHD) model in combination with the Sagdeev pseudopotential method to explore the effects of Thomas-Fermi nonuniform electron distribution, Coulomb interactions, electron exchange and ion correlation on the large-amplitude nonlinear soliton dynamics in Fermi-Dirac plasmas. It is found that in the presence of strong interactions significant differences in nonlinear wave dynamics of Fermi-Dirac plasmas in the two distinct regimes of nonrelativistic and relativistic degeneracies exist. Furthermore, it is remarked that first-order corrections due to such interactions (which are proportional to the fine-structure constant) are significant on soliton dynamics in nonrelativistic plasma degeneracy regime rather than relativistic one. In the relativistic degeneracy regime, however, these effects become less important and the electron quantum-tunneling and Pauli-exclusion dominate the nonlinear wave dynamics. Hence, application of non-interacting Fermi-Dirac QHD model to study the nonlinear wave dynamics in quantum plasmas such as compact stars is most appropriate for the relativistic degeneracy regime. [1][2][3][4][5][6][7]. This is mainly due to the quantum nature of particle interactions involved in this kind of plasmas. An idealized Fermi-plasma model is the one in which fermions have much lower energies compared to the characteristic Fermi energy defined by the total number of fermions. In such case the quantum plasma is referred to as the zerotemperature quantum plasma. Despite the name, i.e. zero-temperature, it has been shown that such model is useful in description of some compact stellar objects with relatively higher temperatures as 10 4 K [8]. In a noninteracting low density degenerate Fermi gas model which is usually considered for solid-state materials the Pauli exclusion [9] is the dominant quantum effect although the quantum tunneling may also play a role in hydrodynamic properties of plasma. It has been shown that the tunneling effect which has negative pressure-like nature can lead to dissipation of nonlinear structures in quantum plasmas [10][11][12].The main reason for increasing interest in the study of quantum plasmas is two-fold.Semiconductors, inertial confined dense plasmas, laser-mater interaction, etc. can be treated as quantum-like plasmas. On the other hand, astrophysical compact-stars such as dwarfs, pulsars, etc. can also be studied within the framework of quantum plasmas. The study of degenerate Fermi gas under extreme conditions such as ultra-high density and magnetic field can lead to a better understanding of internal structures and physical process in superdense astrophysical entities and stellar chain of evolution. Densities of the order 10 6 -10 9 gcm −3 may arise in white-dwarfs due to gigantic gravitational force leading to a final collapse [13,14]. It is well known that the thermodynamical properties [15] and nonlinear wave dynamics [16][17][18] of a degenerate plasma can exhibit distinct behavior in nonrelativist...