We reveal that three-dimensional multi-orbital topological superconductivity can be identified by a bulk measurement, i.e., the temperature dependence of nuclear magnetic relaxation (NMR) rates. Below a critical temperature Tc, the NMR rate in the topological state exhibits an anti-peak profile, which is opposite to the conventional s-wave state. This inversion coherence effect comes from a twist of order parameters with respect to orbital and spin degrees of freedom. Our self-consistent calculations in the model for CuxBi2Se3 prove that the inverse coherence effect appears as a concave temperature dependence of the NMR rates. We propose that a time-reversal-invariant orbitalsinglet spin-triplet topological superconductivity is characterized by the temperature dependence of the NMR rate. [17][18][19]. Among these studies, although the gapless bound states on surfaces at low temperatures are actively studied [9,11,[20][21][22], observing an intrinsic behavior via bulk measurements is rarely argued. In addition, the setups of surface measurements would be sensitively affected by the characteristics of the interfaces between materials and probes. Thus, a bulk measurement sensitive to topological characters is important for supporting results in surface measurements and revealing the properties of Cooper-pair condensations.A key quantity of connecting topological characters with bulk measurements is a correlation function. Current-current correlation functions, for example, lead to the quantized conductance in integer quantum Hall effects [5]. Spin-spin correlation functions are essential for superconductivity since these quantities well reflect the spin-state properties of Cooper pairs. Nuclear magnetic relaxation (NMR) rates (T −1 1 ) are directly related to the spin-spin correlation functions. Therefore, it is interesting and important question to ask whether NMR rates contain any characteristic information on topological superconductivity. Specifically, the coherence effect is notable. The NMR rate in the presence of a spin-singlet swave superconducting state is enhanced just below a critical temperature T c , owing to the coherence factor [23]. This coherence peak (Hebel-Slichter peak) [24,25] comes from the formation of superconducting gaps. The absence of the peak and a power-law behavior of T −1 1 at low temperatures indicate the occurrence of unconventional states [26][27][28].In this paper we claim that the bulk measurements of NMR rates detect a 3D odd-parity fully-gapped topological superconducting state in time-reversal-invariant multi-orbital systems. An inverse coherence effect just below T c is the signature of this odd-parity state; the coherence factor contributes to the NMR rates with an opposite sign to that of the conventional s-wave states. Our self-consistent calculations in the model of Cu x Bi 2 Se 3 [13] show that this sign reversal leads to an anti-peak behavior of the NMR rates below T c . Using the Fermion anticommutation property, we show that the odd parity allows a twist of a gap fun...