Quantum steps to better sequencing

doi:10.1038/nnano.2010.259

Nature Nanotech

2010

DOI: 10.1038/nnano.2010.259

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Quantum steps to better sequencing

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2024

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Next-Generation Sequencing and Emerging Technologies*

Kumar,

Cowley,

Davis

2024

Semin Thromb Hemost

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Genetic sequencing technologies are evolving at a rapid pace with major implications for research and clinical practice. In this review, the authors provide an updated overview of next-generation sequencing (NGS) and emerging methodologies. NGS has tremendously improved sequencing output while being more time and cost-efficient in comparison to Sanger sequencing. The authors describe short-read sequencing approaches, such as sequencing by synthesis, ion semiconductor sequencing, and nanoball sequencing. Third-generation long-read sequencing now promises to overcome many of the limitations of short-read sequencing, such as the ability to reliably resolve repeat sequences and large genomic rearrangements. By combining complementary methods with massively parallel DNA sequencing, a greater insight into the biological context of disease mechanisms is now possible. Emerging methodologies, such as advances in nanopore technology, in situ nucleic acid sequencing, and microscopy-based sequencing, will continue the rapid evolution of this area. These new technologies hold many potential applications for hematological disorders, with the promise of precision and personalized medical care in the future.

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Next-Generation Sequencing and Emerging Technologies*

Kumar,

Cowley,

Davis

2024

Semin Thromb Hemost

View full text Add to dashboard Cite

show abstract

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Quantum steps to better sequencing

Cited by 1 publication

References 10 publications

Next-Generation Sequencing and Emerging Technologies*

Next-Generation Sequencing and Emerging Technologies*

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