Let (U, U ı ) be a quantum symmetric pair of Kac-Moody type. The ıquantum groups U ı and the universal ıquantum groups U ı can be viewed as a generalization of quantum groups and Drinfeld doubles U. In this paper we formulate and establish Serre-Lusztig relations for ıquantum groups in terms of ıdivided powers, which are an ı-analog of Lusztig's higher order Serre relations for quantum groups. This has applications to braid group symmetries on ıquantum groups.