We introduce new invariants of Hamiltonian fibrations with values in the suitably twisted K-theory of the base. Inspired by techniques of geometric quantization, our invariants arise from the family analytic index of a family of natural Spin c -Dirac operators. As an application we give new examples of non-trivial Hamiltonian fibrations, that have not been previously detected by other methods. As one crucial ingredient we construct a potentially new homotopy equivalence map, with a certain naturality property, from BU to the space of index 0 Fredholm operators on a Hilbert space, using elements of modern theory of homotopy colimits.