QUARTET: A SIOP Europe project for quality and excellence in radiotherapy and imaging for children and adolescents with cancer

Kelly, Sarah; Effeney, Rachel; Gaze, Mark; Bernier-Chastagner, Valérie; Blondeel, Anne; Clementel, E.; Corning, C.; Dieckmann, Karin; Essiaf, Samira; Gandola, Lorenza; Janssens, Geert O.; Kearns, Pamela; Lacombe, Denis; Lassen‐Ramshad, Yasmin; Merks, Hans; Miles, Elizabeth; Padovani, Laëtitia; Scarzello, Giovanni; Schwarz, Rudolf; Timmermann, Beate; Rijn, Rick R. van; Vassal, Gilles; Boterberg, Tom; Mandeville, Henry

doi:10.1016/j.ejca.2022.05.037

Cited by 22 publications

(12 citation statements)

References 21 publications

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“…The ease of use is especially important when dealing with rare diseases, as many centres will only encounter a handful of patients annually. A suitable solution for this is the ‘Quality and Excellence in Radiotherapy and Imaging for Children and Adolescents with Cancer across Europe in Clinical Trials’ (QUARTET) project, which is driven by the European Society for Paediatric Oncology (SIOPE) [ 83 , 84 ]. QUARTET is embedded in the infrastructure of the European Organisation for Research and Treatment of Cancer (EORTC), ensuring a stable and practice-proven platform.…”

Section: Future Perspectivesmentioning

confidence: 99%

Imaging in rhabdomyosarcoma: a patient journey

et al. 2023

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Rhabdomyosarcoma, although rare, is the most frequent soft tissue sarcoma in children and adolescents. It can present as a mass at nearly any site in the body, with most common presentations in the head and neck, genitourinary tract and extremities. The optimal diagnostic approach and management of rhabdomyosarcoma require a multidisciplinary team with multimodal treatment, including chemotherapy and local therapy. Survival has improved over the last decades; however, further improvement in management is essential with current 5-year overall survival ranging from 35% to 100%, depending on disease and patient characteristics. In the full patient journey, from diagnosis, staging, management to follow-up after therapy, the paediatric radiologist and nuclear physician are essential members of the multidisciplinary team. Recently, guidelines of the European paediatric Soft tissue sarcoma Study Group, the Cooperative Weichteilsarkom Studiengruppe and the Oncology Task Force of the European Society of Paediatric Radiology (ESPR), in an ongoing collaboration with the International Soft-Tissue Sarcoma Database Consortium, provided guidance for high-quality imaging. In this educational paper, given as a lecture during the 2022 postgraduate ESPR course, the multi-disciplinary team of our national paediatric oncology centre presents the journey of two patients with rhabdomyosarcoma and discusses the impact on and considerations for the clinical (paediatric) radiologist and nuclear physician. The key learning points of the guidelines and their implementation in clinical practice are highlighted and up-to-date insights provided for all aspects from clinical suspicion of rhabdomyosarcoma and its differential diagnosis, to biopsy, staging, risk stratification, treatment response assessment and follow-up.

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Section: Future Perspectivesmentioning

confidence: 99%

Imaging in rhabdomyosarcoma: a patient journey

et al. 2023

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“…All QUARTET FQs, BOA certificates, and CDC reports submitted for the purposes of site RTQA approval within the European paediatric Soft tissue Sarcoma Group FaR-RMS 2 (EUDRACT 2018-000515-24); SIOP Europe Neuroblastoma group VERITAS 3 (EUDRACT 2015-003130-27) and HR-NBL2 4 (EUDRACT 2019-001068-31), and SIOP Brain Tumour Group HRMB 5 (EUDRACT 2018-004250-17) trials were collated, and a descriptive analysis of participating institutions performed. Institutions with site RTQA approval completed by 31/10/2022 were included.…”

Section: Methodsmentioning

confidence: 99%

“…t h e g r e e n j o u r n a l . c o m been described [3]. Aside from creating a co-ordinated resource of paediatric radiotherapy expertise, two of the main QUARTET responsibilities are to assess and approve centres delivering radiotherapy prior to them commencing study recruitment, and to provide prospective Individual Case Review (ICR) of radiotherapy treatment plans for each patient.…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

Radiotherapy quality assurance in paediatric clinical trials: first report from six QUARTET-affiliated trials

Kelly

Turcas

Corning

et al. 2023

Radiotherapy and Oncology

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“…Quality and Excellence in Radiotherapy and Imaging for Children and Adolescents with Cancer across Europe in Clinical Trials is a project from the International Society of Paediatric Oncology-Europe in partnership with the European Organisation for Research and Treatment of Cancer to facilitate prospective QA across participating paediatric trials in Europe. 32 Machine QA is performed by the radiation physicist and secures the optimal functioning of the equipment in all its aspects. Critical items are checked daily, while less critical or variable items will be monitored less frequently.…”

Section: Plan Generation and Dosimetrymentioning

confidence: 99%

“…This process can be prospective review by external experts, which is becoming standard in clinical trials, and will provide timely feedback to the treating clinician. Quality and Excellence in Radiotherapy and Imaging for Children and Adolescents with Cancer across Europe in Clinical Trials is a project from the International Society of Paediatric Oncology-Europe in partnership with the European Organisation for Research and Treatment of Cancer to facilitate prospective QA across participating paediatric trials in Europe 32…”

Section: The Radiotherapy Pathwaymentioning

confidence: 99%

Contemporary paediatric radiation oncology

Boterberg¹,

Dunlea

Harrabi

et al. 2022

Arch Dis Child

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Treatment with ionising radiation is a valuable component of treatment schedules for a many children and young people with cancer. While some form of radiotherapy has been in use for over 100 years, a series of innovations has revolutionised paediatric radiation oncology. Mostly, high-energy X-ray photons are used, but proton beam radiotherapy is increasingly offered, especially in children and young people. This is to reduce the radiation exposure of healthy normal tissues and so the likelihood of adverse effects. Other methods of radiotherapy delivery include brachytherapy and molecular radiotherapy. The most appropriate treatment technique should be selected for every child. Advances in computers and imaging, developments in the technology of radiation delivery and a better understanding of pathology and molecular biology of cancer, coupled with parallel improvements in surgery and systemic therapy, have led to a transformation of practice in recent decades. Initially an empirical art form, radiotherapy for children has become a technically advanced, evidence-based cornerstone of increasingly personalised cancer medicine with solid scientific foundations. Late sequelae of treatment—the adverse effects once accepted as the cost of cure—have been significantly reduced in parallel with increased survival rates. The delivery of radiotherapy to children and young people requires a specialised multiprofessional team including radiation oncologists, therapeutic radiographers, play specialists and physicists among others. This article reviews the types of radiotherapy now available and outlines the pathway of the child through treatment. It aims to demonstrate to paediatricians how contemporary paediatric radiation oncology differs from past practice.

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QUARTET: A SIOP Europe project for quality and excellence in radiotherapy and imaging for children and adolescents with cancer

Cited by 22 publications

References 21 publications

Imaging in rhabdomyosarcoma: a patient journey

Imaging in rhabdomyosarcoma: a patient journey

Radiotherapy quality assurance in paediatric clinical trials: first report from six QUARTET-affiliated trials

Contemporary paediatric radiation oncology

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