Quartz-Crystal Microbalance (QCM) for Public Health

Bragazzi, Nicola Luigi; Amicizia, Daniela; Panatto, Donatella; Tramalloni, Daniela; Valle, Ivana La; Gasparini, Roberto

doi:10.1016/bs.apcsb.2015.08.002

Cited by 50 publications

(28 citation statements)

References 361 publications

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“…Quartz crystal microbalance (QCM) belongs to the larger group of BAW that has been studied extensively and applied to many fields. For example, coated QCM with antibody and gold nanoparticles has been used recently for disease diagnosis and antigen detection in solutions [ 70 , 71 , 72 , 73 , 74 ]. Study of cells can be conducted through the examination of cell-substrate adhesion with QCM [ 75 , 76 ].…”

Section: Gas Sensing Methodsmentioning

confidence: 99%

Affinity Ionic Liquids for Chemoselective Gas Sensing

Chang

Chang³

et al. 2018

Molecules

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Selective gas sensing is of great importance for applications in health, safety, military, industry and environment. Many man-made and naturally occurring volatile organic compounds (VOCs) can harmfully affect human health or cause impairment to the environment. Gas analysis based on different principles has been developed to convert gaseous analytes into readable output signals. However, gas sensors such as metal-oxide semiconductors suffer from high operating temperatures that are impractical and therefore have limited its applications. The cost-effective quartz crystal microbalance (QCM) device represents an excellent platform if sensitive, selective and versatile sensing materials were available. Recent advances in affinity ionic liquids (AILs) have led them to incorporation with QCM to be highly sensitive for real-time detection of target gases at ambient temperature. The tailorable functional groups in AIL structures allow for chemoselective reaction with target analytes for single digit parts-per-billion detection on mass-sensitive QCM. This structural diversity makes AILs promising for the creation of a library of chemical sensor arrays that could be designed to efficiently detect gas mixtures simultaneously as a potential electronic in future. This review first provides brief introduction to some conventional gas sensing technologies and then delivers the latest results on our development of chemoselective AIL-on-QCM methods.

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Section: Gas Sensing Methodsmentioning

confidence: 99%

Affinity Ionic Liquids for Chemoselective Gas Sensing

Chang

Chang³

et al. 2018

Molecules

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“…Implementations in medicine and environmental monitoring are currently two fields, which benefit from the QCM technique owing to its reliability, high sensitivity, and ability to deposit a wide spectrum of materials. An important feature is also the short response time providing real-time results [ 36 ]. The QCM has been successfully utilized for diagnosis of diseases such as cancer [ 21 , 37 , 38 , 39 ] as well as viral [ 40 ] and bacterial [ 41 ] infections.…”

Section: Qcm Technology Basicsmentioning

confidence: 99%

Application of QCM in Peptide and Protein-Based Drug Product Development

2020

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AT-cut quartz crystals vibrating in the thickness-shear mode (TSM), especially quartz crystal resonators (QCRs), are well known as very efficient mass sensitive systems because of their sensitivity, accuracy, and biofunctionalization capacity. They are highly reliable in the measurement of the mass of deposited samples, in both gas and liquid matrices. Moreover, they offer real-time monitoring, as well as relatively low production and operation costs. These features make mass sensitive systems applicable in a wide range of different applications, including studies on protein and peptide primary packaging, formulation, and drug product manufacturing process development. This review summarizes the information on some particular implementations of quartz crystal microbalance (QCM) instruments in protein and peptide drug product development as well as their future prospects.

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“…Compared to most of the other types of biosensors; piezoelectric biosensors are generally suitable for a label free assay and it records direct affinity interaction with surface, rather than chemical or physical properties of the medium, such as the other types of biosensors. Common reviews surveying principles and general applications of the piezoelectric biosensors are given in references [19,20,88,89,90,91,92,93]. An idealized principle of a piezoelectric biosensor containing an antibody and directly reacting with analyte is depicted in Figure 4.…”

Section: Piezoelectric Biosensors For Biological Warfare Agents Assaymentioning

confidence: 99%

Current Trends in the Biosensors for Biological Warfare Agents Assay

Pohanka

2019

Materials

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Biosensors are analytical devices combining a physical sensor with a part of biological origin providing sensitivity and selectivity toward analyte. Biological warfare agents are infectious microorganisms or toxins with the capability to harm or kill humans. They can be produced and spread by a military or misused by a terrorist group. For example, Bacillus anthracis, Francisella tularensis, Brucella sp., Yersinia pestis, staphylococcal enterotoxin B, botulinum toxin and orthopoxviruses are typical biological warfare agents. Biosensors for biological warfare agents serve as simple but reliable analytical tools for the both field and laboratory assay. There are examples of commercially available biosensors, but research and development of new types continue and their application in praxis can be expected in the future. This review summarizes the facts and role of biosensors in the biological warfare agents’ assay, and shows current commercially available devices and trends in research of the news. Survey of actual literature is provided.

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Quartz-Crystal Microbalance (QCM) for Public Health

Cited by 50 publications

References 361 publications

Affinity Ionic Liquids for Chemoselective Gas Sensing

Affinity Ionic Liquids for Chemoselective Gas Sensing

Application of QCM in Peptide and Protein-Based Drug Product Development

Current Trends in the Biosensors for Biological Warfare Agents Assay

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