Quartz Crystal Microbalance with Dissipation (QCM-D) studies of the viscoelastic response from a continuously growing grafted polyelectrolyte layer

Dunér, Gunnar; Thormann, Esben; Dédinaité, Andra

doi:10.1016/j.jcis.2013.07.008

Cited by 60 publications

(63 citation statements)

References 46 publications

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“…The measurement of ∆D is based on the fact that the voltage over the crystal decays exponentially as a damped sinusoidal when the driving power of a piezoelectric oscillator is switched off. 29 By switching the driving voltage on and off periodically, a series of changes of the resonant frequency and the dissipation factor can be obtained simultaneously. The profiles of ∆f and ∆D versus time are evaluated with the Q-Tools software.…”

Section: Quartz Crystal Microbalance With Dissipation (Qcm-d)mentioning

confidence: 99%

Desorption Mechanism of Asphaltenes in the Presence of Electrolyte and the Extended Derjaguin–Landau–Verwey–Overbeek Theory

et al. 2015

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Desorption of asphaltenes from silica-coated quartz crystals upon exposure to a series of saline solutions was studied through the measurements of quartz crystal microbalance with dissipation (QCM-D), atomic force microscopy (AFM), and contact angle. Interestingly, it was found that the mass loading and thickness of asphaltene film decreased during the injection of sodium chloride solution at the concentrations ranging from 1 mM to 10 mM, with the surface tending to be hydrophilic; whereas, the mass loading and film thickness increased gradually when the concentration increased from 10 mM to 1000 mM, with the surface inclined to be hydrophobic. It was also found that the electrostatic force had a great effect on this process due to the interactions between the charged interfaces of oil/water and water/solid. Besides, some additional interactions may arise under small distance at the presence of the electrolyte solution, and therefore, a direct force-measuring technique was introduced, in which the functionalized AFM tips felt a solid surface to model the interactions among three phases of oil, water, and solid. Based on the computed results of disjoining pressure isotherms, the theory of Derjaguin-Landau-Verwey-Overbeek (DLVO) was extended, taking into account of the participation of hydration forces which played an important role at short range. These structural forces mostly originated from the overlap of the hydrated layers under a variety of salinity concentrations, resulting in the balance of resultant interactions.

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Section: Quartz Crystal Microbalance With Dissipation (Qcm-d)mentioning

confidence: 99%

Desorption Mechanism of Asphaltenes in the Presence of Electrolyte and the Extended Derjaguin–Landau–Verwey–Overbeek Theory

et al. 2015

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“…However, for larger species, such as hydrogel microparticles, these assumptions would not be valid. In order to properly study these thick, viscoelastic films with QCM‐D, one would need to apply a continuum mechanics model that includes viscous and elastic contributions, such as the Voigt model …”

Section: Resultsmentioning

confidence: 99%

“…The dissipation measurement is a ratio of the lost (i.e., viscous) to stored (i.e., elastic) energy during the oscillation of the crystal. It is calculated using the following relationship:

D = \frac{E_{l}}{2 π E_{s}} = \frac{1}{πfτ}

where D is the dissipation measurement, E l is the loss energy, E s is the stored energy, ƒ is the frequency measurement, and τ is the time constant for the amplitude decay of the quartz crystal when the driving voltage is turned off …”

Section: Methodsmentioning

confidence: 99%

“…where D is the dissipation measurement, E l is the loss energy, E s is the stored energy, ƒ is the frequency measurement, and τ is the time constant for the amplitude decay of the quartz crystal when the driving voltage is turned off. 25 As the bound layer undergoes a physical transition that increases its viscous behavior (e.g., swelling, degradation of crosslinks) the dissipation increases. Conversely, as the sensor-bound layer increases in elasticity (e.g., hysteresis resulting in a loss of bound water), the dissipation decreases.…”

Section: Calculations and Assumptionsmentioning

confidence: 99%

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QCM‐D assay for quantifying the swelling, biodegradation, and protein adsorption of intelligent nanogels

Clegg

Ludolph

Peppas

2019

J of Applied Polymer Sci

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Environmentally responsive nanomaterials have been developed for drug delivery applications, in an effort to target and accumulate therapeutic agents at sites of disease. Within a biological system, these nanomaterials will experience diverse conditions which encompass a variety of solute identities and concentrations. In this study, we developed a new quartz crystal microbalance with dissipation (QCM‐D) assay, which enabled the quantitative analysis of nanogel swelling, protein adsorption, and biodegradation in a single experiment. As a proof of concept, we employed this assay to characterize non‐degradable and biodegradable poly(acrylamide‐co‐methacrylic acid) nanogels. We compared the QCM‐D results to those obtained by dynamic light scattering to highlight the advantages and limitations of each method. We detailed our protocol development and practical recommendations, and hope that this study will serve as a guide for others to design application‐specific QCM‐D assays within the nanomedicine domain. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48655.

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“…QCM-D technique has been used widely in different studies, i.e: cellular characterization [25,26,[91][92][93], protein detection [27,[94][95][96][97][98] and DNA detection [99][100][101][102][103][104], and viscosity analysis of different substances [37,46,67,100,[105][106][107][108].…”

Section: Impulse Excitation and Decay Methodsmentioning

confidence: 99%

Diseño y evaluación de un biosensor basado en resonadores de cristal de cuarzo (QCR) para caracterizar muestras biológicas relacionadas con enfermedades artríticas

Ahumada¹,

Armando²

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IVResumen de la tesis de Luis Armando Carvajal Ahumada, presentada como requisito parcial para la obtención del grado de DOCTOR en INGENIERÍA BIOMÉDICA. Madrid, 03 de Abril de 2017 DISEÑO Y EVALUACIÓN DE UN SENSOR BASADO EN RESONADORES DE CRISTAL DE CUARZO (QCR) PARA CARACTERIZAR MUESTRAS BIOLÓGICAS RELACIONADAS CON LA DIAGNOSIS DE ENFERMEDADES ARTRÍTICASResumen:Los resonadores de cristal de cuarzo son dispositivos ampliamente utilizados como biosensores debido a su alta sensibilidad ante fenómenos físico-químicos que ocurren en su superficie, a la reproducibilidad de las mediciones y por ser transductores fáciles de utilizar. Sauerbrey[1] fue el primero en demostrar que el resonador cristal de cuarzo puede ser utilizado como una microbalanza útil para caracterizar pequeñas deposiciones de masa en el electrodo del cristal. Sauerbrey demostró que, si se deposita una delgada capa de material rígido sobre el cristal de cuarzo, tanto el cristal como el material depositado vibrarán a la misma frecuencia y se generará un cambio en la frecuencia de resonancia inicial del cristal. Específicamente, la frecuencia de resonancia disminuye al aumentar la cantidad de masa depositada.El cristal de cuarzo también puede operar en medio fluidos. En este caso además del desplazamiento en frecuencia del cristal, se genera una pérdida significativa en el factor de calidad del resonador. Para fluidos Newtonianos (viscosidad constante), Kanazawa y Gordon[2] demostraron que el desplazamiento en frecuencia que sufre el resonador así como el cambio en el ancho de la curva de admitancia, depende de la densidad y la viscosidad del líquido. Este fenómeno permite utilizar los resonadores de cristal de cuarzo como pequeños viscosímetros siempre que se conozca la densidad del fluido a analizar.En el caso de deposición de fluidos viscoelásticos, la medición del cambio en la frecuencia de resonancia del cristal no es suficiente para obtener el valor de viscosidad del fluido. Por tanto, se requiere de la medición de una segunda variable (mitad del ancho de media banda -Γ) para obtener el valor correcto de la viscosidad del fluido depositado.[3] Para fluidos pseudoplásticos (viscosidad aparente dependiente de la velocidad de cizallamiento aplicada), se requiere de un modelo matemático que explique el comportamiento de la viscosidad del fluido a distintas velocidades de cizallamiento. En particular para el análisis de muestras con este comportamiento, se ha elegido el modelo Rouse ya que explica con suficiente detalle el comportamiento pseudoplástico y resulta simple de aplicar a las medidas experimentales.En este trabajo se propone el diseño de un biosensor basado en un resonador de cristal de cuarzo (QCR) para la caracterización de muestras biológicas que emulan el comportamiento del líquido sinovial.El líquido sinovial es una mezcla de plasma dializado y ácido hialurónico con comportamiento pseudoplástico. Su principal función es la de actuar como lubricante en las articulaciones V manteniendo al mínimo la fricción entre los huesos, especialment...

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Quartz Crystal Microbalance with Dissipation (QCM-D) studies of the viscoelastic response from a continuously growing grafted polyelectrolyte layer

Cited by 60 publications

References 46 publications

Desorption Mechanism of Asphaltenes in the Presence of Electrolyte and the Extended Derjaguin–Landau–Verwey–Overbeek Theory

Desorption Mechanism of Asphaltenes in the Presence of Electrolyte and the Extended Derjaguin–Landau–Verwey–Overbeek Theory

QCM‐D assay for quantifying the swelling, biodegradation, and protein adsorption of intelligent nanogels

Diseño y evaluación de un biosensor basado en resonadores de cristal de cuarzo (QCR) para caracterizar muestras biológicas relacionadas con enfermedades artríticas

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