In order to quantitatively grasp the influence of asymmetry of a channel, flow in an eccentric sudden expansion channel, in which the channel centers are different on the upstream and downstream sides, was calculated to be less than the Reynolds number of 400, where the expansion rate was 2. The asymmetry of a channel is expressed by an eccentricity S, where a symmetric expansion channel is S = 0 and a channel with one side step is S = 1. Both flows firstly reattached on the wall located on the short and long side of a sudden expansion and were observed in the range of S ≤ 0.2, although only the former was seen in the range of S > 0.2. The critical Reynolds number of the multiple solutions increases parabolically to S. At least two separation vortices occur, and the third separation vortex is generated in both solutions above the critical Reynolds number of the third vortex. The length of an entrance region increases linearly to the Reynolds number and slightly with the increase in S. The pressure drop coefficient is proportional to the power of the Reynolds number and increases with S.