Quasielastic light scattering studies of aqueous biliary lipid systems. Size, shape, and thermodynamics of bile salt micelles

“…Three models have been proposed: primary micelles, which are formed at low detergent concentration, having a disk shaped structure with one or two bile salt layers (model I) [31][32][33], and at higher detergent concentration, secondary micelles, where the aggregates are stabilised via hydrogen bondings between different primary micelles. Kawamura et al [34] have proposed another model, where the aggregates form a disk shaped structure with a single bile salt layer (model II).…”

Section: Compartment Concentrationmentioning

confidence: 99%

Membranolytic Activity of Bile Salts: Influence of Biological Membrane Properties and Composition

et al. 2007

View full text Add to dashboard Cite

Abstract:The two main steps of the membranolytic activity of detergents: 1) the partitioning of detergent molecules in the membrane and 2) the solubilisation of the membrane are systematically investigated. The interactions of two bile salt molecules, sodium cholate (NaC) and sodium deoxycholate (NaDC) with biological phospholipid model membranes are considered. The membranolytic activity is analysed as a function of the hydrophobicity of the bile salt, ionic strength, temperature, membrane phase properties, membrane surface charge and composition of the acyl chains of the lipids. The results are derived from calorimetric measurements (ITC, isothermal titration calorimetry). A thermodynamic model is described, taking into consideration electrostatic interactions, which is used for the calculation of the partition coefficient as well as to derive the complete thermodynamic parameters describing the interaction of detergents with biological membranes (change in enthalpy, change in free energy, change in entropy etc). The solubilisation properties are described in a so-called vesicle-to-micelle phase transition diagram. The obtained results are supplemented and confirmed by data obtained from other biophysical techniques (DSC differential scanning calorimetry, DLS dynamic light scattering, SANS small angle neutron scattering).

show abstract

“…As the concentration increases: monomer, primary aggregates and secondary aggregates of almost constant properties occur. Correspondingly, the first CMC (CMC 1 ) was defined as the critical micelle concentration at which primary aggregates begin to form, and the second CMC (CMC 2 ) was defined as the critical micelle concentration at which secondary aggregates begin to form [35][36][37]. Therefore, Eq.…”

Section: Molar Solubilization Ratio (Msr) Of Nadc Nac Sds and B-cdmentioning

confidence: 99%

Solubilization and adsorption behaviors of 2,4,6-trichlorophenol in the presence of surfactants

Zeng

Peng

Liu

et al. 2013

Chemical Engineering Journal

View full text Add to dashboard Cite

h i g h l i g h t sThe solubility of 2,4,6-trichlorophenol was enhanced 72 times by sodium deoxycholateat pH 7.5. NaDC demonstrated the best solubilization potential, followed by NaC, SDS and b-CD. The adsorption of 2,4,6-trichlorophenol was almost zero when NaC concentration was above CMC 2 . a r t i c l e i n f o t r a c tThe solubilization of 2,4,6-trichlorophenol (2,4,6-TCP) was studied in the presence of four different surfactants, namely sodium deoxycholate (NaDC), sodium cholate (NaC), sodium lauryl sulfate (SDS) and bcyclodextrin (b-CD). The solubility of 2,4,6-TCP was enhanced a maximum of 72 times especially by NaDC at pH 7.5. In addition, other than great solubilization capacities, NaDC and NaC have the advantages of high biodegradability and biocompatibility as biosurfactants. The adsorption behaviors of 2,4,6-TCP on the surface of soil in the presence of these solubilizers were examined. The results showed that the adsorption isotherms for all studied surfactants matched the Henry adsorption isotherm well. The adsorption mechanisms were explored and the adsorption behaviors of 2,4,6-TCP were affected by different micelle forms of the surfactants based on their critical micelle concentration (CMC). The adsorption process was demonstrated by a redistribution procedure between surfactants in solution and surfactants adsorbed onto the soil surface. In particular, the adsorption of 2,4,6-TCP was almost zero when NaC concentration was above CMC 2 .The results of our study have important implications for soil remediation and non-point source pollution control.

show abstract

Quasielastic light scattering studies of aqueous biliary lipid systems. Size, shape, and thermodynamics of bile salt micelles

Cited by 303 publications

References 20 publications

Solubility and micelle-water partitioning of polychlorinated biphenyls in solutions of bile salt micelles

Solubility and micelle-water partitioning of polychlorinated biphenyls in solutions of bile salt micelles

Membranolytic Activity of Bile Salts: Influence of Biological Membrane Properties and Composition

Solubilization and adsorption behaviors of 2,4,6-trichlorophenol in the presence of surfactants

Contact Info

Product

Resources

About