Quassinoids: Phytochemistry and antitumor prospect

Duan, Zhi-Kang; Zhang, Zhaojun; Dong, Shu-Hui; Wang, Yuxi; Song, Shao‐Jiang; Huang, Xiao‐Xiao

doi:10.1016/j.phytochem.2021.112769

Cited by 21 publications

(16 citation statements)

References 143 publications

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“…Interestingly, there exists a structure with 20 carbons appearing in the top 10 skeletons of triterpenoids (the eighth; Fig. 2c), which belongs to a series of bitter compounds called quassinoids mainly found in the Simaroubaceae family (Duan et al ., 2021).…”

Section: Resultsmentioning

confidence: 99%

Chemotaxonomic investigation of plant terpenoids with an established database (TeroMOL)

et al. 2022

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Summary Terpenoids constitute the biggest class of plant‐derived natural products with diverse chemical structures and extensive biological activities. Interpreting enzyme functions and mining new structures of terpenoids could be inspired by the cheminformatic and chemotaxonomic analysis, whereas it is hampered by the incompleteness of available data for terpenoids. Here a dedicated terpenoids database, TeroMOL, is developed to collect more than 170 000 terpenoids and their derivatives annotated with reported biological sources, along with a user‐friendly and freely accessible webserver to visualise and analyse the terpenoids skeletons and organism sources. The quantitative distributions as well as the qualitative trends between terpenoid skeletons and organism sources in plant kingdom are revealed from a chemotaxonomic view, while no comparisons are attempted due to the inherent data biases. Nevertheless, the terpenoid chemomarkers in several organisms are discussed based on the available data with highly enriched and exclusive carbon skeletons. We believe that the TeroMOL database and its accessory computational tools will be very promising for exploring the chemical space and biological sources of terpenoids, and assisting the terpenoid research community in the future.

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Section: Resultsmentioning

confidence: 99%

Chemotaxonomic investigation of plant terpenoids with an established database (TeroMOL)

et al. 2022

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“…While the quassinoid terpenes bruceine A ( 3.31 ) and D ( 3.32 ) reported from the Chinese medicinal plant Brucea javanica (Simaroubaceae) ( yadanzi ) were strongly active against the fish flatworm D. intermedius (EC 50 0.49 and 0.57 μg mL −1 , respectively), 68 they were also potent inhibitors of cell proliferation by inducing apoptosis, 69,70 and exhibited antimalarial, anti-inflammatory, antifeedant, insecticidal, amoebicidal, antiulcer and herbicidal activities. 70 It was also recently reported that 3.31 had an apoptosis-like effect on the reproductive tissues of C. elegans .…”

Section: Plantsmentioning

confidence: 99%

Natural products as anthelmintics: safeguarding animal health

et al. 2023

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“…Within the last few years, several original research papers and in-depth reviews have been published discussing the biological function and structure-activity relationship (SAR) of quassinoids; consequently, this topic is not covered in detail herein. [48][49][50] In general, the α,β-unsaturated ketone in ring A, the C-15 ester side chain, and the tetrahydrofuran bridge are key contributors to bioactivity; however, the mechanism of action of different quassinoids likely diverges considerably, and specific targets have rarely been unambiguously linked to the biological properties observed in phenotypic assays. The lack of mechanistic understanding is clearly one of the main factors currently limiting the therapeutic potential of quassinoids.…”

Section: Selected Structure-activity Relationships and Investigations...mentioning

confidence: 99%