Quaternary ammonium N,N,N-trimethyl chitosan derivative and povidone‑iodine complex as a potent antiseptic with enhanced wound healing property

Abueva, Celine; Ryu, Hyun Seok; Min, Jeong Jin; Chung, Phil‐Sang; You, Hyeon Sook; Yang, Myung Suk; Woo, Seung Hoon

doi:10.1016/j.ijbiomac.2021.05.153

Cited by 25 publications

(14 citation statements)

References 36 publications

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“…Quaternized chitosan (QCH) is a partial derivative of CH, showing outstanding solubility, and biodegradability. It is frequently used as raw biopolymer to construct antibacterial materials, due to its higher antimicrobial activity and improved water solubility compared to native chitosan [ 85 ]. Innovative hydrogel dressing with outstanding scavenging property and significant antibacterial performance against both gram positive and negative bacteria was synthesized by introducing tannic acid into QCH polymeric matrix [ 86 ].…”

Section: Polymeric Compoundsmentioning

confidence: 99%

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

et al. 2023

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Rapid and complete wound healing is a clinical emergency, mainly in pathological conditions such as Type 2 Diabetes mellitus. Many therapeutic tools are not resolutive, and the research for a more efficient remedial remains a challenge. Wound dressings play an essential role in diabetic wound healing. In particular, biocompatible hydrogels represent the most attractive wound dressings due to their ability to retain moisture as well as ability to act as a barrier against bacteria. In the last years, different functionalized hydrogels have been proposed as wound dressing materials, showing encouraging outcomes with great benefits in the healing of the diabetic wounds. Specifically, because of their excellent biocompatibility and biodegradability, natural bioactive compounds, as well as biomacromolecules such as polysaccharides and protein, are usually employed in the biomedical field. In this review, readers can find the main discoveries regarding the employment of naturally occurring compounds and biopolymers as wound healing promoters with antibacterial activity. The emerging approaches and engineered devices for effective wound care in diabetic patients are reported and deeply investigated.

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Section: Polymeric Compoundsmentioning

confidence: 99%

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

et al. 2023

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“…As shown in Figure 3 , for the 1 H-NMR spectrum of CS, the proton signal peak of H1 on the hetero ring appeared at 4.692 ppm, and the proton signal peak of the methyl moieties of the acetyl group appeared at 1.507 ppm [ 27 ]. For the 1 H-NMR spectrum of N-2-HACC, the proton signal peak of H1 on the hetero ring appeared at 4.692 ppm, and the -N + (CH 3 ) 3 proton signal peak on the N-2-HACC branched chain appeared at 3.170 ppm [ 28 ], indicating the occurrence of substitution reaction on the C-NH 2 of CS. The FTIR and 1 H-NMR spectra of CS and N-2-HACC suggest a success in the introduction of EPTAC into the free amino group of CS, which means the smooth generation of target product N-2-HACC.…”

Section: Resultsmentioning

confidence: 99%

Self-Assembly of Soluble Chitosan Derivatives Nanoparticles for Vaccine: Synthesis, Characterization and Evaluation

Liu

et al. 2021

Polymers

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Herein, a novel chitosan derivative nanoparticle was proposed to function as a delivery carrier. First of all, an improvement was made to the way N-2-hydroxypropyl trimcthyl ammonium chloride chitosan (N-2-HACC) was synthesized. Moreover, the solution to one-step synthesis of N-2-HACC from chitosan (CS) was developed. Different from the previous report, the synthesis process was simplified, and there was a reduction in the amount of 2,3-epoxypropyl trimethyl ammonium chloride (EPTAC) used. With its excellent water solubility maintained, the relatively low degree of substitution was controlled to facilitate the cross-linking reaction. The results obtained from 1H-NMR, FTIR spectroscopy, and XRD indicated a smooth EPTAC onto CS for the formation of N-2-HACC with 59.33% the degree of substitution (DS). According to our results, N-2-HACC could be dissolved in various organic solvents, deionized water, 1% acetic acid aqueous solution, and others at room temperature. Finally, a novel chitosan nanoparticle material was prepared using the self-assembly method with β-glycerophosphate sodium (β-GC), with excellent immune properties achieved, thus providing a new strategy for chitosan self-assembled nanoparticles.

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“…The in vivo wound healing ability was evaluated in a rat model, which demonstrated better formation of collagen and re-epithelialization with respect to the formulation without TMC. The study findings suggested the potential of the developed solution with no cytotoxic effect . The efficacy of TMC fibers with various degrees of quaternization was investigated by Zhou et al The developed TMC fibers showed excellent antibacterial activity against both Gram-positive (>99%) and Gram-negative bacteria (>63%).…”

Section: Biomedical Applications Of Modified Chitosanmentioning

confidence: 99%

Chitosan Derivatives as Carriers for Drug Delivery and Biomedical Applications

Manna

Seth

Gupta

et al. 2023

ACS Biomater. Sci. Eng.

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Over the past few decades, chitosan (CS) has gained the attention of researchers investigating newer biomaterial-based carriers for drugs in pharmaceutical and biomedical research. Combined with its nontoxic behavior, biodegradability, and biocompatibility, chitosan has found widespread applications in the fields of drug delivery, tissue engineering, and cosmetics. As a novel drug carrier, chitosan is regarded as one of the promising biomaterials in the pharmaceutical industry. The extensive use of this cationic biopolysaccharide in the delivery of therapeutic agents has brought a few limitations of chitosan into the limelight. Various chemical modifications of chitosan can minimize these limitations and improve the efficacy of chitosan as a drug carrier. The effectiveness of several chemically modified chitosan derivatives, including trimethyl chitosan, thiolated chitosan, PEGylated chitosan, and other chitosan derivatives, has been investigated by many researchers for the controlled and target specific delivery of therapeutics. The chemically modified chitosan derivatives exhibited greater importance in the current scenario on drug delivery due to their solubility in wide range of media along with their interaction with pharmaceutically active ingredients. Chitosan derivatives have also attracted attention in several biomedical fields, including wound healing, hyperthermia therapy, tissue engineering, and bioadhesives. The present review narrates the sources and common physicochemical properties of chitosan, including several important synthetic modifications to obtain chemically modified chitosans and their applications in targetspecific drug delivery, along with several biomedical applications.

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Quaternary ammonium N,N,N-trimethyl chitosan derivative and povidone‑iodine complex as a potent antiseptic with enhanced wound healing property

Cited by 25 publications

References 36 publications

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

Self-Assembly of Soluble Chitosan Derivatives Nanoparticles for Vaccine: Synthesis, Characterization and Evaluation

Chitosan Derivatives as Carriers for Drug Delivery and Biomedical Applications

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