Quaternary derivatives of granatanol diesters: Potent, ultrashort acting non-depolarizing neuromuscular relaxants

Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs

“…In that clinical use of many novel neuromuscular blocking drugs has been precluded by an unfavorable cardiopulmonary response profile, [6][7][8] the current study was designed to define the effect of incrementally larger doses of CW002 on hemodynamics, ventilation pressures, and pulmonary compliance. Our data indicate that when given at supratherapeutic doses, CW002 produces dose-related effects on hemodynamics, particularly systemic blood pressure.…”

“…A limitation to the clinical use of many novel neuromuscular blocking drugs has been an unfavorable cardiopulmonary response profile manifest as histamine release, hypotension, either primary (ganglionic blockade) or secondary (reflex) tachycardia, and/or bronchospasm. [6][7][8] Previous investigation in dogs has demonstrated that gantacurium does not elicit any effect on peak inspiratory pressure or lung compliance but will induce histamine release and a decrease in arterial blood pressure when…”

Synthesis and antimicrobial activity of a series of optically active quaternary ammonium salts derived from phenylalanine

“…QUATs are not only active against diseases caused by bacteria or fungi, but also exhibit antiprotozoal [20,21], antineoplastic [22][23][24] and immunomodulatory activity [25]. They act as neuromuscular relaxants [26], as selective inhibitors of Aβ fibril formation [27], or as antagonists to neuronal nicotinic acetylcholine receptors mediating dopamine release [28,29]. Recently QUATs and polycationic compounds have been intensively investigated as possible non-viral vectors for gene transfection [30][31][32][33].…”

In vivo animal studies with sugammadex

“…Development of ultra‐short acting NMBs with only a small variability in time course of action might solve the problem. Many compounds have been synthesised and studied [10–14]. However, none of them has fulfilled the desired profile, and many have caused histamine release or adverse cardiovascular effects, or have even been toxic.…”