The Mediterranean Sea is particularly sensitive to global climate and environmental changes at different timescales. Records of these changes have been widely documented through paleoceanographic reconstructions using deep sea sediments, with an emphasis on the last few glacial to interglacial cycles and the Holocene. Regarding targeted regions, the westernmost Mediterranean is among the most studied, with many studies focusing in the Alboran Sea. The eastern basin has also been the focus of a wide number of paleoreconstructions, particularly to understand the origin, timing and characteristics of sapropels, the organic carbon-rich layers that characterize this basin. In this presentation, we focus on the relatively shallow Strait of Sicily, in the central Mediterranean, a much less studied area, despite being a region of very active water interchange between the eastern and western Mediterranean Sea. For this, we selected sediment core LC07 (38°08.72'N, 10°04.73'E; 23.66 m, 488 m water depth), which provides a low resolution continuous record covering more than a million years. Organic molecular proxies were analyzed to reconstruct past changes in sea surface temperatures (SST), continental inputs, export production and phytoplankton composition. Sicily Strait alkenone SSTs evolved following the typical glacial/interglacial oscillations, with values comparable to those reconstructed in the Alboran Sea and the Gulf of Lions, but with slightly higher absolute values in line with the progressive warming that surface waters experience during their transit from the Strait of Gibraltar, through the African Margin and towards the Central Mediterranean. Regarding terrigenous markers, n-alcohols concentrations oscillated in a very similar way to brassicasterol, indicating a possible link between continental inputs, rich in Fe and Si, and diatom productivity through enhanced fertilization. Alkenone concentrations displayed maximum values at periods different to those of brassicasterol, so both algae seem to have proliferated at different periods of time. Diatoms were apparently more abundant during times with important continental inputs and water stratification, while coccolithophores tended to develop more during glacial -interglacial transitions. Interestingly, some of the peaks in the marine markers corresponded with the timing of sapropels, inferring peculiar marine conditions in the Central Mediterranean during these events, with alternation between phytoplankton populations.