Quaternized N-substituted carboxymethyl chitosan derivatives as antimicrobial agents

Mohamed, Nadia A.; Sabaa, Magdy W.; Elghandour, Ahmed H.; Abdel‐Aziz, Marwa M.; Abdel-Gawad, Omayma F.

doi:10.1016/j.ijbiomac.2013.05.022

Cited by 81 publications

(44 citation statements)

References 24 publications

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“…In accordance with the antifungal activity against mycelial growth, pyridine chitosan was more active against spores of both B. cinerea and F. fulva (88% and 97%, respectively). It has been reported that chitosan was very effective for the inhibition of spore germination (Mohamed et al, 2013). The present results of the inhibition performance were consistent with the previous report, which also depended on the types of fungi and the nature of the substituent of the derivative.…”

Section: Spore Germinationsupporting

confidence: 93%

Pyridine-grafted chitosan derivative as an antifungal agent

et al. 2016

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Section: Spore Germinationsupporting

confidence: 93%

Pyridine-grafted chitosan derivative as an antifungal agent

et al. 2016

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“…As shown in this table, the prepared polymer showed a better antibacterial activity due to presence of NH group and aromatic ring, thus increasing its partially cationic character [13,14]. Consequently the positive charge was strengthened, leading to a better antibacterial activity [15]. Polypyrrole showed higher antibacterial activity against the gram positive bacteria.…”

Section: Antibacterial Activitymentioning

confidence: 90%

Antibacterial activity of nano fabricated polypyrrole by cyclic voltammetry

Sayyah¹,

Mohamed²,

Shaban³

2014

IOSRJAC

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“…There has been significant interest in the study of antimicrobial chitosan derivatives, as is evident from the many recent original publications [34,57,58,59] and reviews [27,60,61]. However, taken together, previous studies have not provided a clear picture of the structure-activity relationship.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Substituent, Degree of Acetylation and Positioning of the Cationic Charge on the Antibacterial Activity of Quaternary Chitosan Derivatives

et al. 2014

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A series of water-soluble cationic chitosan derivatives were prepared by chemoselective functionalization at the amino group of five different parent chitosans having varying degrees of acetylation and molecular weight. The quaternary moieties were introduced at different alkyl spacer lengths from the polymer backbone (C-0, C-2 and C-6) with the aid of 3,6-di-O-tert-butyldimethylsilyl protection of the chitosan backbone, thus allowing full (100%) substitution of the free amino groups. All of the derivatives were characterized using 1H-NMR, 1H-1H COSY and FT-IR spectroscopy, while molecular weight was determined by GPC. Antibacterial activity was investigated against Gram positive S. aureus and Gram negative E. coli. The relationship between structure and activity/toxicity was defined, considering the effect of the cationic group’s structure and its distance from the polymer backbone, as well as the degree of acetylation within a molecular weight range of 7–23 kDa for the final compounds. The N,N,N-trimethyl chitosan with 100% quaternization showed the highest antibacterial activity with moderate cytotoxicity, while increasing the spacer length reduced the activity. Trimethylammoniumyl quaternary ammonium moieties contributed more to activity than 1-pyridiniumyl moieties. In general, no trend in the antibacterial activity of the compounds with increasing molecular weight or degree of acetylation up to 34% was observed.

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Quaternized N-substituted carboxymethyl chitosan derivatives as antimicrobial agents

Cited by 81 publications

References 24 publications

Pyridine-grafted chitosan derivative as an antifungal agent

Pyridine-grafted chitosan derivative as an antifungal agent

Antibacterial activity of nano fabricated polypyrrole by cyclic voltammetry

The Effect of Substituent, Degree of Acetylation and Positioning of the Cationic Charge on the Antibacterial Activity of Quaternary Chitosan Derivatives

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