Que savons-nous de la rétinopathie diabétique au centre hospitalier universitaire Sourô Sanou de Bobo-Dioulasso (CHUSS) ?

Diallo, J.W.; Dolo, Mariam; Sanou, J.; Yoda, Aicha; Ahnoux-Zabsonré, Ahgbatouhabéba; Méda, N.

doi:10.1016/j.jfo.2018.11.002

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…It is close to the 33% of Nwosu et al [6] in Nigeria in 2000 and 36.6% of Tchabi et al [7] in Benin in 2012. However, Abouki et al [8] in Benin in 2016, Kouassi et al [9] in Côte-d'Ivoire in 2018 and Diallo et al [10] in Burkina-Faso in 2014 found higher frequencies of 43.33%, 45% and 47.1% respectively. Rajoana et al [11] in 2016 in Madagascar reported a higher frequency of 65.8%.…”

Section: Frequency Of Diabetic Retinopathymentioning

confidence: 99%

Risks Factors Associated with Diabetic Retinopathy at the National University Hospital Center Hubert Koutoukou Maga in Cotonou

Hodé¹,

Abouki²,

Dedjan³

et al. 2023

JDM

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Diabetic retinopathy (DR) is one of the microvascular complications of diabetes. The aim of this study was to analyze the risk factors associated with the occurrence of diabetic retinopathy (DR) at the National University Hospital Center-Hubert Koutoukou MAGA (CNHU-HKM). Patients and method: this was a descriptive and analytical cross-sectional study with prospective data collection. It was carried out over a three-month period from July 10 to October 10, 2019. It concerned all patients suffering from diabetes mellitus and who consulted in the Endocrinology department during the study period. Results: the frequency of diabetic retinopathy was 30.46% (53/174 patients). A female predominance was observed with a sex ratio (M/F) of 0.57. The main modifiable risk factors were represented by occupation and those that were not modifiable were represented by the presence of old nephropathy, glycated hemoglobin, age of discovery of diabetes and its length of service. Diabetic retinopathy is a serious condition that can ultimately lead to blindness. The frequency of DR remains high in our study.

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Section: Frequency Of Diabetic Retinopathymentioning

confidence: 99%

Risks Factors Associated with Diabetic Retinopathy at the National University Hospital Center Hubert Koutoukou Maga in Cotonou

Hodé¹,

Abouki²,

Dedjan³

et al. 2023

JDM

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“…Diabetic retinopathy (DR) is a common microvascular complication of diabetes (Cheung et al, 2010;Henriques et al, 2015;Diallo et al, 2019). Early features of DR include blood-retina barrier (BRB) breakdown, capillary acellularity and pericyte loss and it has been confirmed that the main factor contributing to the progression of DR is chronic hyperglycemia (Stitt et al, 2016;Powers et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

MiR-124-3p Suppresses the Dysfunction of High Glucose-Stimulated Endothelial Cells by Targeting G3BP2

Zhao

2021

Front. Genet.

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Background: Diabetic retinopathy (DR) is the most important manifestation of diabetic microangiopathy. MicroRNAs (miRNAs), members of non-coding RNAs, have been frequently reported to regulate various diseases including DR. MiR-124-3p is involved in DR based on bioinformatics. The current study aimed to investigate the role of miR-124-3p in high glucose (HG)-treated human retinal microvascular endothelial cells (HRMECs), an in vitro model of DR.Methods: Bioinformatics analysis was applied to reveal the targets downstream miR-124-3p. A series of assays including CCK-8, luciferase reporter, western blot, and tube formation assays were used to explore the function and mechanism of miR-124-3p in HG-stimulated HRMECs.Results: We found out that miR-124-3p was downregulated in HG-stimulated HRMECs. Functionally, miR-124-3p overexpression restrained the HG-induced cell injury of HRMECs. Mechanistically, we predicted 5 potential target mRNAs of miR-124-3p. G3BP stress granule assembly factor 2 (G3BP2) was validated to bind with miR-124-3p. Rescue assays showed that miR-124-3p suppressed cell injury of HG-stimulated HRMECs through G3BP2. In addition, miR-124-3p regulated the p38MAPK signaling pathway by G3BP2, and G3BP2 promoted injury of HG-treated HRMECs through the activation of the p38MAPK signaling pathway.Conclusion: MiR-124-3p suppressed the dysfunctions of HG-treated HRMECs by targeting G3BP2 and activating the p38MAPK signaling. This new discovery provided a potential biomarker for DR treatment.

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Que savons-nous de la rétinopathie diabétique au centre hospitalier universitaire Sourô Sanou de Bobo-Dioulasso (CHUSS) ?

Cited by 2 publications

References 11 publications

Risks Factors Associated with Diabetic Retinopathy at the National University Hospital Center Hubert Koutoukou Maga in Cotonou

Risks Factors Associated with Diabetic Retinopathy at the National University Hospital Center Hubert Koutoukou Maga in Cotonou

MiR-124-3p Suppresses the Dysfunction of High Glucose-Stimulated Endothelial Cells by Targeting G3BP2

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