Desperate Housewives, an American sitcom aired in 2004, takes American housewives as the theme, sets in the middle-class area of Wisteria Lane, and tracks the lives of four housewives with different personalities, Susan, Lynette, Bree and Gabrielle, following the plight they face: all kinds of pressures in life, and the contradiction between the shackles of tradition and the demands for independence and freedom of modern women, which make these housewives almost desperate. In this paper, the reasons for the female plight in the context of the times will be analyzed, and feminism in Desperate Housewives will be explored based on intersectionality theory, feminist media study theory, and post-feminism. Finally, the female plight hidden in the opening animation will be analyzed through multimodal theory.