Quelamycin, a new derivative of adriamycin with several possible therapeutic advantages

Gosálvez, Mario; Blanco, M.F.; Vivero, C.; Valles, Francisco

doi:10.1016/0014-2964(78)90224-4

Cited by 76 publications

(26 citation statements)

References 4 publications

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“…The early suggestion that an iron-adriamycin complex, quelamycin, ameliorates the cardiac toxicity of adriamycin has not been substantiated in other investigations (77,78). One of the problems with this work was the use of a mixture of iron and Adr with a stoichiometry of Fe3Adr, which does not represent the actual coordination stoichiometry Fe(Adr)2 or Fe(Adr)3 (77).…”

Section: Esr Studies Of Iron Adriamycin Fe(adr)3mentioning

confidence: 97%

“…One of the problems with this work was the use of a mixture of iron and Adr with a stoichiometry of Fe3Adr, which does not represent the actual coordination stoichiometry Fe(Adr)2 or Fe(Adr)3 (77). Recently, an iron adriamycin complex that has been difficult to characterize has been shown to bind to erythrocyte ghost membranes and is involved in lipid peroxidation (79).…”

Section: Esr Studies Of Iron Adriamycin Fe(adr)3mentioning

confidence: 99%

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ESR of Copper and Iron Complexes with Antitumor and Cytotoxic Properties

Antholine¹,

Kalyanaraman²,

Petering³

1985

Environmental Health Perspectives

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The relatively few iron and copper metal complexes which have been examined in cells and tissues for their redox properties, radical generation properties, and antitumor activity are discussed for studies which utilized electron spin resonance spectroscopy (ESR). A common property of a number of metal complexes, which include bleomycin, adriamycin, and thiosemicarbazones described in this review, is that they are readily reduced by thiol compounds and oxidized by oxygen or reduced species of oxygen to produce radicals. Structural features ofthese reactions are identified by ESR spectroscopy in model systems and-often in cells. Furthermore, ESR spectroscopy has been most useful to probe the environment of the complexes in cells and to measure the rate of reduction of their oxidized forms. As a result of these studies, it is anticipated that more attention will be given to the exploration of redox-active metal complexes as drugs.

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Section: Esr Studies Of Iron Adriamycin Fe(adr)3mentioning

confidence: 97%

Section: Esr Studies Of Iron Adriamycin Fe(adr)3mentioning

confidence: 99%

ESR of Copper and Iron Complexes with Antitumor and Cytotoxic Properties

Antholine¹,

Kalyanaraman²,

Petering³

1985

Environmental Health Perspectives

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“…The dose of doxorubicin (8 mg/kg of body weight) that we applied was relatively high, corresponding to 80% of the lethal dose (LD50) for intravenous administration in rats (18) and 55%-80% of the lethal dose (LD50) for intraperitoneal administration in mice (19,20). The transient decline of body weight of rats that we observed after a single intraperitoneal dose of doxorubicin was also noticed in other studies (21) and was apparently related to a temporary reduction of food intake.…”

Section: Discussionmentioning

confidence: 99%

Rapid Reduction of 1-Receptor Binding and 18F-FDG Uptake in Rat Gliomas After In Vivo Treatment with Doxorubicin

Waarde¹,

Shiba²,

Jong³

et al. 2007

Journal of Nuclear Medicine

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“…It is well known that the co-encapsulation of metal-ligand complexes has enabled the release of several drugs in synergistic ratios to maximize antidisease activity and minimize toxicity and this has been used in the clinic. [16] Recently, it has been shown that the combination of high and regular porosity with the presence of organic groups within the metal-organic framework combines the advantages of both to achieve a high drug loading and a controlled release. [17] Pt-ligand coordination bonding combined with the nanoscale coordination of polymers with amorphous silica shells has been used to effectively control the release of a drug.…”

Section: Introductionmentioning

confidence: 99%

A pH‐Responsive Cleavage Route Based on a Metal–Organic Coordination Bond

Liu

Zheng

Che

2011

Chemistry A European J

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The physical or chemical event that generally causes stimuli responses is limited to the formation or destruction of secondary forces, such as hydrogen bonding, hydrophobic effects, electrostatic interactions, and simple reactions. Here, pH-responsive behavior of metal-organic coordination bonding, which is intrinsic to natural systems (e.g., transferrin recycling in cells), is becoming a strong candidate for a new stimulus-responsive route. We have designed a simple pH-responsive release system by integrating a metal ion and ligand or self-assembling these species with biodegradable host molecules to form nanoparticles with "metal-ligand" or "host-metal-ligand" architectures. The cleavage of either or both the "metal-ligand" or the "host-metal" coordination bond in response to pH variations causes significant damage to the nanoparticles and the subsequent release of ligand molecules under designated pH conditions.

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Quelamycin, a new derivative of adriamycin with several possible therapeutic advantages

Cited by 76 publications

References 4 publications

ESR of Copper and Iron Complexes with Antitumor and Cytotoxic Properties

ESR of Copper and Iron Complexes with Antitumor and Cytotoxic Properties

Rapid Reduction of 1-Receptor Binding and 18F-FDG Uptake in Rat Gliomas After In Vivo Treatment with Doxorubicin

A pH‐Responsive Cleavage Route Based on a Metal–Organic Coordination Bond

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