Quenching of singlet molecular oxygen by Commiphora myrrha extracts and menthofuran

Racine, Philippe; Auffray, Benoit

doi:10.1016/j.fitote.2005.03.017

Cited by 32 publications

(11 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This experiment clearly shows the efficiency of Commiphora myrrha against singlet oxygen as was previously published [12] whereas the olive extract and BHT do not show a significant quenching activity of singlet oxygen Table 2.…”

Section: O 2 Experimentssupporting

confidence: 84%

See 1 more Smart Citation

Protection against singlet oxygen, the main actor of sebum squalene peroxidation during sun exposure, using Commiphora myrrha essential oil

Auffray¹

2007

Intern J of Cosmetic Sci

Self Cite

View full text Add to dashboard Cite

Squalene is a component of sebum. Both are directly exposed to the external environment and play a key role in skin physiology. They are particularly prone to photo oxidation during sun exposure. We studied the impact of two types of antioxidant on sebum squalene peroxidation by UV irradiation. The first type is free radical scavenger (Butyl hydroxyl toluene and an olive extract rich in hydroxytyrosol). The second type is the essential oil of Commipora myrrha, a singlet oxygen quencher. These properties were confirmed using the 2,2-diphenyl-1-picrylhydrazyl test for antiradical capacity [Yoshida et al. (1989) Chem. Pharm. Bull., 37, 1919; Buenger et al. (2006) Int. J. Cosmet. Sci., 28, 135] and 1,3-diphenylisobenzofuran test for the capacity to quench singlet oxygen [Kochewar and Redmond (2000) Meth. Enzymol., 28, 319; Racine and Auffray (2005) Fitoterapia, 76, 316]. Furthermore, we have extended an ex vivo method to classify the efficacy of cosmetics to protect squalene by collecting sebum in vivo and irradiating it in a controlled way. The squalene monohydroperoxide formation is monitored by high performance liquid chromatography. This methods allows us to compare the efficiency of the three antioxidants at 0.6% in a cosmetic formulation to protect squalene from photo oxidation. Our results clearly show that essential oil of Commiphora myrrha provides the best protection against squalene peroxidation. These results demonstrate that squalene peroxidation during solar exposure is mainly because of singlet oxygen and not due to free radical attack. This suggests that sun care cosmetics should make use not only of free radical scavengers but also of singlet oxygen quenchers.

show abstract

Section: O 2 Experimentssupporting

confidence: 84%

“…This assay [11,12] tests the ability of quenching singlet oxygen. Slight modifications were made from the previous method.…”

Section: O 2 Assaymentioning

confidence: 99%

Protection against singlet oxygen, the main actor of sebum squalene peroxidation during sun exposure, using Commiphora myrrha essential oil

Auffray¹

2007

Intern J of Cosmetic Sci

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, it has been reported that C. myrrha mediates its cytoprotective actions by suppressing NO production due to induction of HO-1 (Chen et al, 2005;Zhang et al, 2011). The GC-MS analysis that was carried out in our study indicated the presence of curezerine, deltaelemene, beta-elemene, 3-[(E)-2-phenyl-1-propenyl] cyc, bicycle [3.1.1]hept-2-ene-2-car, 8-isopropenyl-9-isopropyltetra, and 2,4-bis(3-methyl-1-pentynyl)-4, which were reported to have antioxidant, cytoprotective as well as anticancer properties (Fraternale et al, 2011;Marcotullio et al, 2011;Racine & Auffray, 2005). Liver histological changes to the inflammatory response such as fatty changes, focal central vein congestion, vocalization, necrosis, and loss of cellular boundaries were visible throughout many lobules in the D-GalN/LPS-administered group.…”

Section: Discussionmentioning

confidence: 79%

Hepatoprotective effect ofCommiphora myrrhaagainstd-GalN/LPS-induced hepatic injury in a rat model through attenuation of pro inflammatory cytokines and related genes

Ahmad

Raish

Ganaie

et al. 2015

Pharmaceutical Biology

View full text Add to dashboard Cite

(2015) Hepatoprotective effect of Commiphoramyrrha against d-GalN/LPS-induced hepatic injury in a rat model through attenuation of pro inflammatory cytokines and related genes, Pharmaceutical Biology, 53:12, 1759-1767, DOI: 10.3109/13880209.2015 Results: The administration of D-GalN/LPS increased plasma aminotransferases (174.47 ± 4.5761 and 260.96 ± 1.9839 mkat/l) and total bilirubin levels (1.012 ± 0.0288 mg/dl), which were attenuated by C. myrrha treatment. Hepatic lipid peroxidation activity and nitric oxide content also increased, while the antioxidant activity measured by GSH (0.76 nmol/g protein), SOD (81.91 U/mg protein), and CAT (15.78 U/mg protein) was reduced. Commiphora myrrha provided significant restoration of GSH (0.815 nmol/gm protein), SOD (140.57 U/mg protein), and CAT (27.02 U/mg protein) levels. Furthermore, the acute phase response elicited by D-GalN/ LPS administration enhanced mRNA expressions of TNF-a, IL-6, IL-10, iNOS-2, and HO-1, which were ameliorated by C. myrrha treatment. Discussion and conclusion: These findings indicate that C. myrrha considerably reduces the oxidative stress of D-GalN/LPS-induced hepatic injury via multiple pathways including adown regulation of inflammatory mediators and cytokines. Such a property might be sufficient to combat cellular damage caused by various conditions that resemble fulminant hepatitis and could be of a potential clinical application.

show abstract

“…The essential oil of C. myrrha exhibited potent singlet oxygen quenching activity better than the control a-tocopherol. This effect was attributed by the reaction between furan ring of C. myrrha constituents (particular the furanosesquiterpenoids) and singlet oxygen (Racine and Auffray, 2005). Three furanosesquiterpenoids (27-29) from C. myrrha showed DPPH radical scavenging activity with EC 50 values of 1.08, 4.29 and 2.56 mg/mL (Fraternale et al, 2011).…”

Section: Antioxidant Activitymentioning

confidence: 99%

The genus Commiphora: A review of its traditional uses, phytochemistry and pharmacology

Shen

Wang

et al. 2012

Journal of Ethnopharmacology

217

161

View full text Add to dashboard Cite

Quenching of singlet molecular oxygen by Commiphora myrrha extracts and menthofuran

Cited by 32 publications

References 12 publications

Protection against singlet oxygen, the main actor of sebum squalene peroxidation during sun exposure, using Commiphora myrrha essential oil

Protection against singlet oxygen, the main actor of sebum squalene peroxidation during sun exposure, using Commiphora myrrha essential oil

Hepatoprotective effect ofCommiphora myrrhaagainstd-GalN/LPS-induced hepatic injury in a rat model through attenuation of pro inflammatory cytokines and related genes

The genus Commiphora: A review of its traditional uses, phytochemistry and pharmacology

Contact Info

Product

Resources

About