Queratodermia acuagénica inducida por celecoxib

Vildosola, S.; Ugalde, Aitziber

doi:10.1016/s0001-7310(05)73129-x

Cited by 36 publications

(20 citation statements)

References 8 publications

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“…A search of the English literature using all proposed terms of TAPH identified 24 cases in the dermatological literature which are summarized in table 1[1,2,3, 5,8,9,10,11,12,13,14,15,16,17,18,19]. However, not included are 12 additional cases of TAPH associated with CF which were published in the 1970s by paediatricians, but lack detailed clinical information [20, 21].…”

Section: Discussionmentioning

confidence: 99%

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Painful Wrinkles in the Bathtub: Association with Hyperhidrosis and Cystic Fibrosis

et al. 2008

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Transient aquagenic palmar hyperwrinkling (TAPH) is a rarely reported cutaneous condition clinically characterized by swelling and hyperwrinkling of the palms, and associated with burning sensations after briefly immersing the hands in water. Upon the withdrawal of water, the symptoms rapidly disappear. We report on a 10-year-old boy with type I diabetes, who developed the typical symptoms of TAPH concomitantly with the onset of palmar hyperhidrosis. Determination of the sodium chloride concentration of the sweat revealed elevated levels. Subsequent screening for the most common mutations of the gene responsible for cystic fibrosis (CF) was negative. Review of the literature shows that TAPH may develop in conditions of increased water absorption due to an increased sweat quantity, such as hyperhidrosis, or an increased sweat electrolyte concentration, such as CF. In the majority of reported cases TAPH has been associated with CF; therefore, it is a cutaneous sign, which should be recognized by dermatologists, and patients should be referred for evaluation of the sodium chloride concentration of the sweat.

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Section: Discussionmentioning

confidence: 99%

“…Complete resolution of symptoms was achieved after withdrawal of the drug in all cases, suggesting a causative role in the pathogenesis [10, 17, 19]. Rofecoxib and celecoxib are selective inhibitors of cyclo- oxygenase-II (COX-II) which is known to increase sodium reabsorption in the kidney.…”

Section: Discussionmentioning

confidence: 99%

Painful Wrinkles in the Bathtub: Association with Hyperhidrosis and Cystic Fibrosis

et al. 2008

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“…While a large proportion of cases of AWP have been found in patients with CF, it has also been reported to be associated with marasmus [1] and with certain medications including cyclo-oxygenase 2 (COX-2) inhibitors [14,15,16] and aminoglycoside antibiotics [17]. …”

Section: Introductionmentioning

confidence: 99%

“…The COX-2 protein is known to be expressed in human keratinocytes [19,20]. The inhibition of COX-2 expression may result in sodium retention in epidermal keratinocytes and thus increased water binding capacity [14,15]. It has been suggested that AWP in CF patients may be mediated by subnormal CFTR regulation of cell membrane water channels [3].…”

Section: Introductionmentioning

confidence: 99%

Aquagenic Wrinkling of the Palms in an Adult Cystic Fibrosis Population

Tolland

Boyle²,

Hall³

et al. 2010

Dermatology

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Background: Aquagenic wrinkling of the palms (AWP) is a rare condition characterised by the development of oedema and excessive wrinkling of the palms following exposure to water. It has frequently been associated with cystic fibrosis (CF). Early reports of AWP have only been case reports or small case series; there has only been one reported prevalence study of AWP in a CF population. Objective: To determine the incidence and characteristics of AWP in the adult CF population in Northern Ireland. Methods: 105 CF patients were interviewed. The patients were asked whether they noticed excess wrinkling of the hands when exposed to water. If they answered ‘yes’, further questions were asked regarding clinical characteristics. The atopic status, CF genotype and drug history were recorded for each patient. Formal testing of 7 patients was carried out. Results: Out of the 105 patients who were interviewed, 43 (41%) described AWP. Of the 43 patients with AWP, 20 were male and 23 were female. There was no association of AWP with genotype, atopy or concomitant drug intake. Conclusion: AWP appears to have an equal sex incidence, and the high number of cases in the population studied would suggest that this condition is underreported.

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“…Hastalığın patogenezinde epidermal sodyum konsantrasyonundaki artış sonucu, epidermal keratinositlerin su bağlama kapasitesindeki artış suçlanmıştır 7 . Benzer mekanizma ile rofekoksib ve selekoksib gibi ilaçların, koksigenaz 2 enzimini inhibe edip terde elektrolit konsantrasyonunu arttırarak ASA gelişimine yol açtığı düşünülmüştür 7,11,13,14 . Çalışmamızda bir olgumuzda tespit edilen alopesi areata dışında eşlik eden hastalık ve ilaç öyküsü yoktu.…”

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Acquired aquagenic acrokeratoderma: A case series

Akpolat¹,

Kılınç²,

Akbaş³

et al. 2016

TURKDERM

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SummaryÖz Turkderm -Arch Turk Dermatol Venerology 2016;50:157-9 Giriş Akuajenik siringeal akrokeratoderma (ASA); 2-4 dakika su teması sonrası oluşan ödematöz beyaz renkli papül ve plaklarla karakterize, etiyolojisi bilinmeyen, nadir, edinsel bir palmoplantar keratoderma türüdür 1,2 . ASA ilk olarak 1996 yılında English ve McCollough tarafından "geçici reaktif papülo translucent akrokeratoderma" ismiyle tanımlanmıştır 3 . Lezyonlar sıklıkla palmar alanda görülmesine rağmen, el dorseli ve ayaklar da etkilenebilir 1,2,4 . Genellikle adölesanları ve genç erişkin kadınları etkiler, bildirilen erkek olgu sayısı sınırlıdır 1,3,5 . Biz burada; kliniğimizde ASA tanısı konulan ve tedavi edilen erkek hastaların klinik ve laboratuvar bulgularını literatür ile karşılaştırarak sunmayı amaçladık.2011-2014 tarihleri arasında, polikliniğimizde klinik ve/veya histopatolojik olarak ASA tanısı konulan hastalar retrospektif olarak incelendi. Poliklinik başvurusu esnasında hastalardan, dosyalarından bilgi alınacağına dair bilgilendirilmiş onam formu alındı. Hastalar, cinsiyet, lezyon başlangıç yaşı, lokalizasyonu, kalıcılığı, eşlik eden semptom ya da hastalık, aile öyküsü ve tedaviye yanıt açısından detaylı olarak gözden geçirildi. Olgu SunumuÇalışmaya suyla temastan kısa süre sonra elleri ve ayaklarında beyazlaşma şikayeti olan, klinik ve/veya histopatolojik olarak Akuajenik siringeal akrokeratoderma (ASA); etiyolojisi bilinmeyen, sıklıkla adölesan ve genç erişkin kadınları etkileyen, nadir, edinsel bir keratoderma türüdür. Klinik olarak suyla temastan birkaç dakika sonra ortaya çıkan, geçici ödematöz beyaz papül ve plaklarla karakterizedir. Sıklıkla palmar yüzeylerde lokalizedir, el dorsalleri ve ayak tabanını da etkileyebilir. Bu çalışmada; literatürde kadın predominansı üzerinde durulmasına rağmen, kliniğimizde ASA tanısı alan altı erkek hastanın klinik özelliklerinin incelenmesi amaçlanmıştır. Anahtar Kelimeler: Akuajenik siringeal akrokeratoderma, erkek, el dorseli Aquagenic syringeal acrokeratoderma (ASA) is a rare kind of an acquired keratoderma that predominantly affects adolescents and young females. The etiology is unknown. Clinically, ASA is characterized by transient edematous white papules and plaques occurring a few minutes after exposure to water. It is most commonly localized on the palms, but may also affect the plantar area and dorsum of the hand. Despite the female predominance mentioned in the literature, the aim of this study was to investigate the clinical characteristics of six male patients diagnosed with ASA in our clinic.

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Queratodermia acuagénica inducida por celecoxib

Cited by 36 publications

References 8 publications

Painful Wrinkles in the Bathtub: Association with Hyperhidrosis and Cystic Fibrosis

Painful Wrinkles in the Bathtub: Association with Hyperhidrosis and Cystic Fibrosis

Aquagenic Wrinkling of the Palms in an Adult Cystic Fibrosis Population

Acquired aquagenic acrokeratoderma: A case series

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