Quercetagetin 5-methyl ether from the petals of Tagetes patula

Bhardwaj, D. K.; Bisht, Madho Singh; Uain, S.C.; Mehta, C.K.; Sharma, Gaurav

doi:10.1016/0031-9422(80)87053-1

Cited by 25 publications

(8 citation statements)

References 3 publications

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“…Flavonoids, such as kaempferol and quercetina, were reported by Ivancheva and Zdravkova [28]. Tarpo [29-31] and Bhardwaj et al [32], recorded the presence of patuletin-7- O -glucoside (patulitrin), patuletin, quercetagetin, quercetagetin-7- O -glucoside and luteolin in petals of T. patula .…”

Section: Introductionmentioning

confidence: 98%

Acaricidal activity of ethanolic extract from aerial parts of Tagetes patula L. (Asteraceae) against larvae and engorged adult females of Rhipicephalus sanguineus (Latreille, 1806)

et al. 2012

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BackgroundThe tick Rhipicephalus sanguineus is the species with the largest worldwide distribution and is proven to be involved in the transmission of pathogens such as Babesia canis, Ehrlichia canis, Coxiella burnetii, Rickettsia ricketsii, Rickettsia conorii, among others. Studies have demonstrated acquisition of resistance to some of the active principles used in commercial formulations of acaricides. Tagetes patula (Asteraceae) is a plant with highlighted economic and commercial importance due to the production of secondary metabolites with insecticide and acaricide potential, mainly flavonoids, thiophenes and terpenes.MethodsThe in vitro acaricide action of the ethanolic 70% extract from aerial parts of T. patula, obtained by percolation, was evaluated against larvae and engorged adult females of Rhipicephalus sanguineus by immersion test for 5 minutes. The chemical characterization of this extract was done by liquid chromatography coupled with mass spectrometry (LC-MS), using direct injection of sample.ResultsDespite T. patula not proving lethal to adults in any of the concentrations tested, at 50.0 mg/mL oviposition rate decreased by 21.5% and eliminated 99.78% of the larvae. Also it was determined that the best results were obtained with 5 minutes of immersion. From the chromatographic analysis twelve O-glycosylated flavonoids were identified.ConclusionsThis is the first report on the acaricidal activity of T. patula extract against Rh. sanguineus. If we consider the application of the product in the environment, we could completely eliminate the larval stage of development of the ixodid Rh. sanguineus.

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Section: Introductionmentioning

confidence: 98%

Acaricidal activity of ethanolic extract from aerial parts of Tagetes patula L. (Asteraceae) against larvae and engorged adult females of Rhipicephalus sanguineus (Latreille, 1806)

et al. 2012

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“…In general, these flowers are used as a coloring or flavoring agent in food and have potential medical use against inflammatory diseases of the skin, as well as insecticidal activity [1, 2]. Previous phytochemical investigations on French marigold have resulted in the isolation of carotenoids [3, 4], flavonoids [5, 6], and monoterpenoids [7]. In our previous studies, we reported the anti-inflammatory action of French marigold [8, 9], and in this paper, we report the inhibitory effects of the flavonol patuletin and its glucoside from methanol extracts of French marigold on acute inflammation models, such as the hind-paw edema induced by γ -carrageenin and histamine and ear edema induced by arachidonic acid (AA) and 12- O -tetradecanoylphorbol-13-acetate (TPA).…”

Section: Introductionmentioning

confidence: 99%

Effects of Flavonoids from French Marigold (Florets ofTagetes patulaL.) on Acute Inflammation Model

Yasukawa

Kasahara

2013

International Journal of Inflammation

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The major components patuletin and patulitrin were isolated from French marigold (florets of Tagetes patula). Patuletin and patulitrin were found to inhibit acute inflammation in mice. Oral administration of patuletin and patulitrin significantly suppressed hind-paw edema induced by carrageenin and histamine, while topical application of patuletin and patulitrin significantly inhibited ear edema induced by 12-O-tetradecanoylphorbol-13-acetate and arachidonic acid. Thus, oral and topical administration of patuletin and patulitrin inhibited acute inflammation in mice. These results suggest the anti-inflammatory efficacy of French marigold.

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“…The leaves are employed in kidney troubles and muscular pain, and the roots and seeds are used as purgative (Chadha, 1976). The chemical constituents of T. patula include alkaloid (Faizi & Naz, 2002), benzofuran (Menelaou et al, 1991), flavonoids and their glycosides (Bhardwaj et al, 1980;Ivancheva & Zdravkova, 1993;Koloshina et al, 1980;Mashkovskaja & Dzuba, 2002), helenien (Tarpo & Cucu, 1961), polyacetylene (Kyo et al, 1990;Towers et al, 1984), steroids and terpenes (Kasprzyk & Kozierowska 1996;Vasudevan et al, 1997), and thiophenes (Kagan, 1991;Kyo et al, 1990;Mares et al, 2002;Margl et al, 2002). The two major classes of pigments present in Tagetes are flavonoids and carotenoids.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Antifungal Activities of Different Parts ofTagetes patula.: Preparation of Patuletin Derivatives

Faizi

Siddiqi

Bano

et al. 2008

Pharmaceutical Biology

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The current study evaluates the antibacterial and antifungal activities of extracts from different parts of Tagetes patula Linn. (Asteraceae), reported for the first time in a single set of experiments. In the preliminary assay, the methanol extract of the flower (JFM) was found to possess antimicrobial activity against a number of bacteria with inhibition zone diameters ranging from 9 to 20 mm, the bioassay-guided fractionation of which led to the isolation of a flavonoid patuletin (3) in high yield as the active antibacterial principle with minimum inhibitory concentration (MIC) value of 12.5 µg/disk against Corynebacterium spp., Staphylococcus spp., Streptococcus spp., and Micrococcus luteus. Its glucoside, patulitrin (4), was found to be weakly active, except against Staphylococcus saprophyticus, Streptococcus fecalis, and Streptococcus pyogenes with inhibition zone diameters of 11, 16, and 12 mm, respectively. The cinnamate derivative (3b) of 3 showed antibacterial activity comparable with the parent flavonoid with a MIC value of 50 µg/disk against Corynebacterium spp., whereas benzoate derivative (3a) was found to be devoid of any activity; both the derivatives are new compounds. Moreover, the longchain alcohol 5, which displayed antibacterial activity in the preliminary testing, was obtained in large quantity directly from the petroleum ether extract of the involucre of the flowers.

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Quercetagetin 5-methyl ether from the petals of Tagetes patula

Cited by 25 publications

References 3 publications

Acaricidal activity of ethanolic extract from aerial parts of Tagetes patula L. (Asteraceae) against larvae and engorged adult females of Rhipicephalus sanguineus (Latreille, 1806)

Acaricidal activity of ethanolic extract from aerial parts of Tagetes patula L. (Asteraceae) against larvae and engorged adult females of Rhipicephalus sanguineus (Latreille, 1806)

Effects of Flavonoids from French Marigold (Florets ofTagetes patulaL.) on Acute Inflammation Model

Antibacterial and Antifungal Activities of Different Parts ofTagetes patula.: Preparation of Patuletin Derivatives

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