Quercetin‑3‑methyl ether suppresses human breast cancer stem cell formation by inhibiting the Notch1 and PI3K/Akt signaling pathways

Cao, Liangqi; Yang, Yunxiao; Ye, Ziyu; Lin, Bihua; Zeng, Jincheng; Li, Caihong; Liang, Tong; Zhou, Keyuan; Li, Jixia

doi:10.3892/ijmm.2018.3741

Cited by 29 publications

(20 citation statements)

References 34 publications

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“…Similarly, one study determined that quercetin-derived cell cycle detention was in S and G2/M phases in MDA-MB-231 breast cancer line [66] in contrast to the G0/G1 phase arrest observed in MCF-7 breast cancer cell line [65]. This variable role of quercetin on cell cycle regulation has also been shown in cells models of non-small cell lung cancer [64] and breast cancer [65,66], and enhanced through its combination [68], encapsulation [69], as well as with quercetin derivatives [71]. Even though quercetin was found to arrest cell cycle progression in several studies included in this systematic review, results were contradictory as opposite effects in cell population percentage were reported.…”

Section: Discussionmentioning

confidence: 76%

Antitumor Effects of Quercetin in Hepatocarcinoma In Vitro and In Vivo Models: A Systematic Review

et al. 2019

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Quercetin is a flavonoid present in fruits, vegetables and plants with antioxidant, anti-inflammatory and anticancer properties. Its beneficial activities have been demonstrated in different human pathologies, including hepatoprotective effects against liver disorders. High mortality and late diagnosis of the primary liver tumor hepatocarcinoma (HCC) makes this cancer an interesting target for the study of quercetin effects. Our aim was to systematically review antitumor activities of quercetin in HCC preclinical studies employing single, encapsulated, combined or derived quercetin forms. Literature search was conducted in PubMed, Scopus and Web of Science (WOS), and 39 studies were finally included. We found that 17 articles evaluated quercetin effects alone, six used encapsulated strategy, 10 combined this flavonoid, two decided to co-encapsulate it and only four studied effects of quercetin derivatives, highlighting that only nine included in vivo models. Results evidence the quercetin antiproliferative and proapoptotic properties against HCC either alone and with the mentioned strategies; nevertheless, few investigations assessed specific activities on different processes related with cancer progression. Overall, further studies including animal models are needed to deeper investigate the precise mechanisms of action of quercetin as antitumor agent, as well as the potential of novel strategies aimed to improve quercetin effects in HCC.

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Section: Discussionmentioning

confidence: 76%

Antitumor Effects of Quercetin in Hepatocarcinoma In Vitro and In Vivo Models: A Systematic Review

et al. 2019

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“…Moreover, the extract showed a similar action to that observed in the same breast cancer lines treated with the main flavonoids present in plant species, which arrest the cell cycle in the G2/M phase through mechanisms of action involving the participation of the PI3K/Akt/mTOR pathway. 71 , 72 …”

Section: Resultsmentioning

confidence: 99%

In silico Prediction on the PI3K/AKT/mTOR Pathway of the Antiproliferative Effect of O. joconostle in Breast Cancer Models

et al. 2022

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The search for new cancer treatments from traditional medicine involves developing studies to understand at the molecular level different cell signaling pathways involved in cancer development. In this work, we present a model of the PI3K/Akt/mTOR pathway, which plays a key role in cell cycle regulation and is related to cell survival, proliferation, and growth in cancer, as well as resistance to antitumor therapies, so finding drugs that act on this pathway is ideal to propose a new adjuvant treatment. The aim of this work was to model, simulate and predict in silico using the Big Data-Cellulat platform the possible targets in the PI3K/Akt/mTOR pathway on which the Opuntia joconostle extract acts, as well as to indicate the concentration range to be used to find the mean lethal dose in in vitro experiments on breast cancer cells. The in silico results show that, in a cancer cell, the activation of JAK and STAT, as well as PI3K and Akt is related to the effect of cell proliferation, angiogenesis, and inhibition of apoptosis, and that the extract of O. joconostle has an antiproliferative effect on breast cancer cells by inhibiting cell proliferation, regulating the cell cycle and inhibiting apoptosis through this signaling pathway . In vitro it was demonstrated that the extract shows an antiproliferative effect, causing the arrest of cells in the G2/M phase of the cell cycle. Therefore, it is concluded that the use of in silico tools is a valuable method to perform virtual experiments and discover new treatments. The use of this type of model supports in vitro experimentation, reducing the costs and number of experiments in the real laboratory.

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“…Quercetin reduces HER2/neu protein level and inhibits the PI3K/AKT signaling pathway (168). Since activation is necessary for cell survival, its inhibition contributes to apoptosis (169). Quercetin activates caspase-3 and -9 and releases cytochrome c in leukemic cells.…”

Section: Indole 3 Carbinol (I3c) Di-indoylmethane (Dim) Andmentioning

confidence: 99%

Anticancer Effects of Nutraceuticals in the Mediterranean Diet: An Epigenetic Diet Model

Divella

Daniele

Savino

et al. 2020

Cancer Genomics Proteomics

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Epidemiological and clinical studies support the association between nutrition and development or progression of different malignancies such as colon, breast, and prostate cancer, defining these tumors as diet-associated cancer. The Mediterranean diet shows inverse associations with metabolic diseases, cardiovascular pathologies and various types of cancer. Many bioactive nutrients of the Mediterranean diet have been identified as factors protective against these types of pathologies. The epigenome has been identified as the primary goal of modulations in gene expression related to these molecular nutrients. In fact, they can modify the epigenome and can be incorporated into the 'epigenetic diet', which translates into a diet regimen that can be used therapeutically for health or preventative purposes. Most epigenetic changes are influenced by lifestyle and nutrition. Epigenetic therapy is a new area for the development of nutraceuticals whose absence of toxicity can represent a valid asset in cancer prevention strategies. Recent advances in understanding the mechanisms of nutrigenomics, nutrigenetics and nutraceuticals have led to the identification of superfoods capable of favorably conditioning gene expression. In this review, we highlight the importance of nutraceuticals present in the Mediterranean diet as epigenetic modifiers both in the mechanisms of tumor onset and as protective agents.

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Quercetin‑3‑methyl ether suppresses human breast cancer stem cell formation by inhibiting the Notch1 and PI3K/Akt signaling pathways

Cited by 29 publications

References 34 publications

Antitumor Effects of Quercetin in Hepatocarcinoma In Vitro and In Vivo Models: A Systematic Review

Antitumor Effects of Quercetin in Hepatocarcinoma In Vitro and In Vivo Models: A Systematic Review

In silico Prediction on the PI3K/AKT/mTOR Pathway of the Antiproliferative Effect of O. joconostle in Breast Cancer Models

Anticancer Effects of Nutraceuticals in the Mediterranean Diet: An Epigenetic Diet Model

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