Quercetin, a Flavonoid Antioxidant, Ameliorated Procarbazine-Induced Oxidative Damage to Murine Tissues

Abstract

Procarbazine (PCZ) (indicated in Hodgkin’s disease), is an alkylating agent known to generate free radicals in vivo, while Quercetin (QCT) is a flavonoid antioxidant with proven free radical scavenging capacity. This study investigated the protective effects of QCT on PCZ-induced oxidative damage in the rat. Male Wistar rats (160–180 g) were randomized into five groups (n = 5/group): I (control), II PCZ-treated (2 mg/kg body weight (bw) for seven days); III pre-treated with QCT (20 mg/kg bw) for seven days, followed by PCZ for seven days; IV co-treated with PCZ and QCT for seven days and V administered QCT alone for seven days. PCZ caused a significant increase in plasma total bilirubin, urea, and creatinine when compared with control (P < 0.05). Similarly, plasma activities of alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyl transferase (γ-GT) were significantly increased in the PCZ-treated group relative to control. Furthermore, PCZ caused a significant decrease in the activities of hepatic superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST) as well as levels of ascorbic acid (AA) and glutathione (GSH). This was followed by a significant increase in hepatic malondialdehyde (MDA) content. However, QCT pre-treatment and co-treatment ameliorated the PCZ-induced changes in plasma levels of urea, creatinine, and bilirubin as well as the activities of ALP, AST, ALT, and GGT. QCT also ameliorated hepatic AA and GSH levels and the activities of SOD, CAT, and GST. This all suggests that QCT protected against PCZ-induced oxidative damage in rats.

Randomized Clinical Trial: Bergamot Citrus and Wild Cardoon Reduce Liver Steatosis and Body Weight in Non-diabetic Individuals Aged Over 50 Years

“…The findings from studies in several cellular models have indicated the ability of dietary polyphenols to counteract ROS production and its associated oxidative damage by controlling mitochondrial membrane potential and oxidative phosphorylation (33,34). Dietary polyphenols can also act indirectly by up-regulating endogenous antioxidant defenses (35,36). Furthermore, these molecules act as potent inducer of lipophagy in animal models of steatosis (11).…”

Composition, antioxidant activities and hepatoprotective effects of the water extract of Ziziphus jujuba cv. Jinsixiaozao

“…7,22,25,26 According to recent reports, avonoids possess a series of biological properties, acting on biological systems as antioxidants. [27][28][29][30] Polysaccharides have received an increased attention due to their antioxidant and hepatoprotective effects. 20,[31][32][33][34][35][36] Our results show that the WEJ was a rich source of polyphenolics, avonoids and polysaccharides which have potential antioxidant activities.…”

Biochemical Evaluation of the Effects of Hydromethanolic Extracts of Dioscorea bulbifera in Wistar Rats

“…[32]. Serum levels of liver enzymes, ALT, AST and ALP have been shown to be reliable markers of hepatotoxicity [33].While the mean values for total protein, ALT and AST was found to be significantly increased in the experimental groups compared to control (p<0.05), the mean values for serum albumin was significantly decreased in the experimental group compared to control (p<0.05).…”