Quercetin: A functional dietary flavonoid with potential chemo‐preventive properties in colorectal cancer

Abstract

Recently, an intense attention has been paid to the application of natural compounds as a novel therapeutic strategy for cancer treatment. Quercetin, a natural flavonol present in many commonly consumed food items, is widely demonstrated to exert inhibitory effects on cancer progression through various mechanisms. Since there is a strong association with diets containing abundant vegetables, fruits, and grains, and significant decline in the risk of colon cancer, accumulation studies have focused on the anticancer potential of quercetin in colorectal cancer. Cell cycle arrest, increase in apoptosis, antioxidant replication, modulation of estrogen receptors, regulation of signaling pathways, inhibition of and metastasis and angiogenesis are among various mechanisms underlying the chemo-preventive effects of quercetin in colorectal cancer. This review covers various therapeutic interactions of Quercetin as to how targets cellular involved in cancer treatment.

Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis

“…Clinical and experimental data have shown the cardio‐ and bowel‐protective functions of this flavonoid . Several fruits and vegetables including capers, dill, cilantro, broccoli, onions, and various berries (such as chokeberries, cranberries, and lingonberries) contain quercetin …”

“…[19][20][21][22] Several fruits and vegetables including capers, dill, cilantro, broccoli, onions, and various berries (such as chokeberries, cranberries, and lingonberries) contain quercetin. 24,25 Quercetin fights oxidative stress by eliminating free radicals and inhibiting oxidation of many molecules. [26][27][28] Furthermore, the flavonoid effectively blocks the proliferation of synoviocytes and the development of angiogenesis in inflammatory processes associated with arthritis.…”

Overcoming multidrug resistance in cancer: Recent progress in nanotechnology and new horizons

“…Other properties of polymeric nanoparticles include higher stability and more uniform size distribution. The preparation of these particles is achieved by the autoassembly of amphiphilic diblock copolymers including biodegradable synthetic polymers such as poly (lactic‐co‐glycolic acid) and polycaprolactone (PCL) as well as natural polymers like polysaccharides and polypeptides . Generally, mixing the drugs with a polymeric solution is the method that is used to achieve drug encapsulation.…”

“…The preparation of these particles is achieved by the autoassembly of amphiphilic diblock copolymers including biodegradable synthetic polymers such as poly (lacticco-glycolic acid) and polycaprolactone (PCL) as well as natural polymers like polysaccharides and polypeptides. 8,10 Generally, mixing the drugs with a polymeric solution is the method that is used to achieve drug encapsulation. For drug encapsulation, drugs and the polymer solution are mixed with the self-assembly of polymers into nanoparticles, where drug compounds are physically entrapped into particles.…”

Rice Bran and Quercetin Produce a Positive Synergistic Effect on Human Gut Microbiota, Elevate the Level of Propionate, and Reduce the Population ofEnterobacteriaceaefamily when Determined using a Bioreactor Model

“…Similarly, quercetin (3,3′,4′,5,7-pentahydroxyflavone) represents an important subgroup of flavonoids found in fruits and leafy vegetables (16). It has received substantial attention in the past few years from the scientific community due to its anti-inflammatory effects (17, 18) and its potential health-promoting properties in the treatment or prevention of cardiovascular diseases (19), lung and colorectal cancers (20, 21), and colitis (11, 22). Furthermore, the mammalian body can endure high levels of quercetin without any significant adverse health effects (23) suggesting its potential food application.…”