Quercetin: A Pleiotropic Kinase Inhibitor Against Cancer

Russo, Gian Luigi; Russo, Maria; Spagnuolo, Carmela; Tedesco, Idolo; Bilotto, Stefania; Iannitti, Roberta; Palumbo, Rosanna

doi:10.1007/978-3-642-38007-5_11

Cited by 146 publications

(123 citation statements)

References 98 publications

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“…It is well documented that Q has broad bioactivity, such as anti-proliferative and anticancer properties [30] [31], anti-fibrotic [32] [33], anti-coagulative [34], antibacterial [35], anti-atherogenic [36] [37], anti-hypertensive [38] [39] and anti-inflammatory capacities [40]- [43]. However, the antioxidant effects of quercetin have been closely linked with the potential generation of reactive pro-oxidant intermediates resulting in mutagen and genotoxicant [44].…”

Section: Introductionmentioning

confidence: 99%

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

El-Denshary¹,

Aljawish²,

El‐Nekeety³

et al. 2015

SNL

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This study was conducted to prepare chitosan nanoparticles (CNPs), to determine their properties and to evaluate the synergistic protective role of CNPs alone or in combination with quercetin (Q) against oxidative stress and hepatotoxicity in rats. Female Sprague-Dawley rats were divided into 12 groups (7 rats/group) and were maintained on their respective diet for 3 weeks as follow: control group, the group treated with CCl4 (100 mg/kg b.w twice a week); the groups received CNPs at low and high doses (140 and 280 mg/kg b.w); the group received Q (50 mg/kg b.w); the groups received CNPs at the low or high doses plus Q and the groups treated with CCl4 plus Q and/or CNPs at the two tested doses. Blood and liver samples were collected at the end of experiment period for biochemical and histological studies. The results indicated that chitosan showed deacetylation degree of 17.5% and 19.2% and the molar mass average of monomer was 168.35 g/mol and 169.1 g/mol by UV and IR methods respectively. The particle size of CNPs was around 100 nm with a rough surface. The in vivo results revealed that CCl4 induced biochemical and histological changes typical to those reported in the literature. Animals treated with CNPs at the two tested doses alone or in combination with Q were comparable to the control. CNPs alone or plus Q succeeded to induce significant improvements in the biochemical parameters and histological picture of the liver in rats treated with CCl4. This improvement was in dose-dependent manner for CNPs and was * Corresponding author. E. S. El-Denshary et al. 37more pronounced in the group treated with the high dose plus Q. It could be concluded that both CNPs and Q could induce protection against hepatotoxicity. Consequently, CNPs was a promise candidate as drug delivery in liver diseases treatments.

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Section: Introductionmentioning

confidence: 99%

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

El-Denshary¹,

Aljawish²,

El‐Nekeety³

et al. 2015

SNL

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“…Following the inhibition of EGFR activation, the downstream signaling pathways and phosphorylation of EGFR, ERK and AKT were suppressed. Similarly to a number of natural compounds, including epigallocatechin gallate (31) and quercetin (32), resveratrol has also been demonstrated to inhibit various kinases (33). The current study only investigated the effect of resveratrol on the EGFR signaling pathway in human ESCC cells, which is one limitation as resveratrol may also target other kinases in ESCC cells.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol mediates cell cycle arrest and cell death in human esophageal squamous cell carcinoma by directly targeting the EGFR signaling pathway

Jin

Feng

et al. 2016

Oncology Letters

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Abstract.Resveratrol is a small polyphenol that has been intensively studied in a wide spectrum of therapeutic fields. More recently, resveratrol has been demonstrated to exert its antitumor activity in numerous tumor models. The present study reported that resveratrol exhibited a marked anti-proliferative effect on human esophageal squamous cell carcinoma (ESCC) cells by inducing cell cycle G 0 /G 1 phase arrest and cell death, which was associated with a decrease in the expression levels of cyclin D1 and an increase in cleaved PARP/cleaved caspase-3 expression levels. The mechanisms underlying the antitumor potency of resveratrol were principally attributed to the downregulation of epidermal growth factor receptor (EGFR) signaling. The western blotting results showed that exposure of ESCC cells to resveratrol inhibited EGF-induced EGFR activation in addition to decreasing the total protein levels of EGFR and membrane/nuclear localization. In summary, the results suggested that resveratrol, or an associated analog, may have a role in the management of human ESCC. IntroductionHuman esophageal squamous cell carcinoma (ESCC) is the 6th leading cause of cancer-associated mortality, and the 8th most common type of cancer worldwide (1). ESCC is the most common histology of esophageal cancers, and has a high incidence in China, South Africa, France and Italy (2). Epidemiological and etiological studies have previously demonstrated that certain environmental and genetic factors have crucial roles in esophageal carcinogenesis (3-7). Although there have been advances in the fields of surgery and chemotherapy, the prognosis for ESCC is typically poor as the majority of patients diagnosed are elderly and present with advanced-stage disease, rendering them unsuitable for curative resection and maintaining the five-year survival rate for ESCC at <15% (1). Therefore, improving the current understanding of the molecular mechanisms underlying ESCC pathogenesis and identifying effective therapeutic agents are required to facilitate the development of novel therapies for this disease.Resveratrol is present in red grapes, wine, nuts and common garden plants, and is one of the most intensively investigated of all the phytochemicals with putative beneficial effects on human health (8). The effects of resveratrol include anti-oxidant and anti-aging properties, improvement of insulin sensitivity and reduction of cardiovascular disease risk (9-11). Previous studies have also indicated that resveratrol is able to function as a chemo preventive and chemotherapeutic agent in certain types of human carcinomas, including those of the colorectum, skin, liver, lung, pancreas, breast and prostate (8,(12)(13)(14). Previous studies suggesting that a dietary pattern rich in resveratrol may reduce the risk of ESCC (15). However, the molecular mechanisms underlying resveratrol-induced antitumor effects have yet to be elucidated. A number of potential mechanisms have been suggested to be involved in resveratrol-induced cancer preventative effects, i...

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“…[26,27] Quercetin has been studied for the treatment of cancer and various other diseases, there is no evidence that quercetin (via supplements or in food) is useful to treat cancer or any disease. [28,29] Hence, quercetin was studied as a chemical marker in rasam.…”

Section: Capsaicinmentioning

confidence: 99%

Marker Based Analytical Studies on Rasam: A South Indian Traditional Functional Food

Devarajan¹

2017

WJPR

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Rasamshowed only the presence of ascorbic acid, capsaicin, ferulic acid and piperine. Furthermore, the study indicated that increase in temperature from RS3 to RS4 decreased the quantity of capsaicin and piperine whereas, the quantity of ascorbic acid increased from RS3 to RS4 in rasam. Ferulic acid remained almost unchanged from RS3 to RS4. Further studies are needed to accurately ascertain the exact chemical composition of rasam apart from the markers studied.

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Quercetin: A Pleiotropic Kinase Inhibitor Against Cancer

Cited by 146 publications

References 98 publications

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

Resveratrol mediates cell cycle arrest and cell death in human esophageal squamous cell carcinoma by directly targeting the EGFR signaling pathway

Marker Based Analytical Studies on Rasam: A South Indian Traditional Functional Food

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