Quercetin: A Potential Polydynamic Drug

Abstract

The study of natural products as potential drug leads has gained tremendous research interest. Quercetin is one of those natural products. It belongs to the family of flavonoids and, more specifically, flavonols. This review summarizes the beneficial pharmaceutical effects of quercetin, such as its anti-cancer, anti-inflammatory, and antimicrobial properties, which are some of the quercetin effects described in this review. Nevertheless, quercetin shows poor bioavailability and low solubility. For this reason, its encapsulation in macromolecules increases its bioavailability and therefore pharmaceutical efficiency. In this review, a brief description of the different forms of encapsulation of quercetin are described, and new ones are proposed. The beneficial effects of applying new pharmaceutical forms of nanotechnology are outlined.

Piper sarmentosum Roxb. Inhibits Angiotensin-Converting Enzyme Activity in Phorbol 12-Myristate-13-Acetate-Induced Endothelial Cells

“…Several strategies have been explored to enhance quercetin’s bioavailability. These strategies often involve the complexation of quercetin with other molecules or encapsulation within delivery systems like cyclodextrins, liposomes, or polymers to improve its stability and absorption [ 51 ]. Improving bioavailability is important as it enhances the effectiveness of quercetin in exerting its potential health benefits, including its antihypertensive properties.…”

Natural Compounds for Bone Remodeling: A Computational and Experimental Approach Targeting Bone Metabolism-Related Proteins

“…To address this challenge, quercetin has been incorporated into innovative lipid-based systems to enhance its bioactivity and therapeutic profile. Nanotechnology strategies, including microparticles, nanostructured lipid carriers, nanoparticles, nanoemulsions, microemulsions, liposomes, phytosomes, niosomes and transferosomes, have been employed for this purpose [79]. The administration of quercetin is typically well tolerated, though minor side effects such as mild headache, nausea and tingling of the extremities may occur with long-term supplementation at 1000 mg/day.…”