Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration

Michaud-Levesque, Jonathan; Bousquet-Gagnon, Nathalie; Béliveau, Richard

doi:10.1016/j.yexcr.2012.02.017

Cited by 173 publications

(122 citation statements)

References 59 publications

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“…Results from another study by Yang et al [60], similar to those obtained by Maciejczyk et al [53] or Yi et al [58] showed that quercetin pretreatment at a low dose may augment drug-resistant ovarian cancer cells for cisplatin chemotherapy by involving the endoplasmic reticulum-stress (ERS) proces via alternation of STAT3 kinase signaling (phosphorylation), a key player involved in ovarian cancer [61,62], modulated by ERS [60]. In this study quercetin decreased the viability of both the C13 * and P-ris cells in a dosedependent manner, with an IC50 value of approximately 100 μM at 48 h; the growth of both cell types could only be significantly inhibited with quercetin concentrations >40 μM, with a negligible cytotoxicity in both cell types at a dose 20 μM.…”

Section: Chemoprotective Activities In Ovarian Cancer Cells Of Quercesupporting

confidence: 53%

Basic Studies on Chemopreventive Properties of Quercetin and Curcumin and Other Plant-origin Compounds in Ovarian Cancer Cells – A Mini-review

Kujawski¹,

Baraniak²,

Ożarowski³

et al. 2017

Altern Integr Med

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Despite the increasing number of studies on the molecular actions of quercetin and curcumin, their anticancer efficacy, safety and molecular aspects of chemopreventive action in the ovarian cancer prophylaxis or treatment and also their potential in the sensitization to cytostatics used in the clinical practice remains still not clearly understood.Based on basic studies we have summarized evidences for inhibitory activities of several often studied plantorigin bio-active compounds (mostly quercetin and curcumin) against ovarian cancer cells proliferation, their mechanisms of action as well as their strong potential to sensitization of ovarian cancer cells to the presence of several platinum-based cytostatics -cisplatin and oxaliplatin. Up to date only several dietary, clinical (cohort and case-control) studies evaluating the association of some flavonoids (mostly nonisoflavones) and its subgroup components consumption and ovarian cancer risk were already performed. According to the researchers, there has been no association between ovarian cancer risk and total nonisoflavone flavonoids intake. There is a still an insufficient amount of data designed to explain the effect of quercetin or curcumin (alone or together) on ovarian cancer development and/or its chemotherapy. Obtained results provide limited support for an association between nonisoflavone flavonoids intake and ovarian cancer risk, therefore there is a need for further and more accurate studies to be confirmed. We are of the opinion that this paper will contribute to a better understanding of the molecular basis for positive interactions between concomitant usage of quercetin or curcumin with above-mentioned cytostatics and other bio-active agents. This work may also contribute to an increase in the number of preclinical studies or other clinical, dietary trials using these or other phenolic / alkaloid, plant-origin constituents in order to investigate efficiency and safety of pharmacotherapy of ovarian cancer patients.

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Section: Chemoprotective Activities In Ovarian Cancer Cells Of Quercesupporting

confidence: 53%

Basic Studies on Chemopreventive Properties of Quercetin and Curcumin and Other Plant-origin Compounds in Ovarian Cancer Cells – A Mini-review

Kujawski¹,

Baraniak²,

Ożarowski³

et al. 2017

Altern Integr Med

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show abstract

“…Quercetin is a polyphenolic compound widely distributed in many vegetals, such as capers, lovage, dill, apple and tea (Gao et al, 2012;Kulisic-Bilusic et al, 2012;Michaud-Levesque et al, 2012). Current researches indicated that quercetin has promising anti-cancer as well anti-inflammatory properties.…”

Section: Quercetinmentioning

confidence: 99%

Targeting Cancer with Nano-Bullets: Curcumin, EGCG, Resveratrol and Quercetin on Flying Carpets

Aras

Khokhar²,

Qureshi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…a component of apples. Accordingly, quercetin has been shown to both block cancer cell growth (19) and to reduce blood pressure in hypertensive subjects (20).…”

Section: Discovery and Hypothesismentioning

confidence: 99%

Proposed interaction between angiotensinogen and retinoblastoma tumor suppressor protein: Potential molecular origin of hypertension

Radulescu¹

2012

Biosci Trends

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Cardiovascular disorders are still the most common cause for morbidity and mortality in industrialized countries. Within this major group of diseases, hypertension plays a leading role. Similar to other important pathologies such as cancer, the prevalence of hypertension increases with aging (1). Currently, among the principal treatments for hypertension are calcium-channel blockers, β-adrenergic antagonists and substances interfering with the reninangiotensin system such as angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers (1). However, it is also known that the therapy of hypertension needs further improvement since it is not infrequent that polypharmacy by means of several different antihypertensive agents is needed to control certain forms of hypertension and, moreover, other (malignant) variants of hypertension are refractory to antihypertensive drug treatment.As a result, the present investigation has aimed for identifying novel antihypertensive drug targets. In this context, I have focused on the potential pathogenetic role of angiotensinogen, i.e. the precursor protein for the hypertensive peptide angiotensin II, that has previously been described to occur in the intracellular compartment of human astrocytes (2) and of human dopaminergic neurons of the substantia nigra compacta (3). Discovery and hypothesis:In the course of analyzing the amino acid sequence of human angiotensinogen, I have now discovered that it harbors the LXFXE amino acid motif (Figure 1) that has previously been defined as a retinoblastoma tumor suppressor protein (RB) binding motif in the viral oncoprotein Tax (4).This novel finding suggests that intracellular angiotensinogen physically interacts with RB and thereby inactivates it, thus leading to cellular hyperproliferation and tissue inflammation both of which ultimately contribute to pathologically increasing blood pressure.This new hypothesis on a potential involvement of angiotensinogen in the pathogenesis of hypertension is consistent with several reports on the inflammationhypertension connection (5-7) along with data showing that the pro-inflammatory cytokine interleukin 6 increases the (plasma) level of angiotensinogen (8) and, moreover, that the angiotensinogen gene is a target for the intracellular pro-inflammatory protein NF-κB (9). In this context, it is worth noting that NF-κB inactivates RB (10) and, conversely, intact RB inhibits the gene regulatory activity of NF-κB through the conformational induction of a transcriptionally inactive NF-κB-DNA complex (11).Given this now proposed candidate role for angiotensinogen in the etiology of hypertension, it should be promising to target the above-described angiotensinogen LXFXE RB-binding motif by means of antiproliferative

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Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration

Cited by 173 publications

References 59 publications

Basic Studies on Chemopreventive Properties of Quercetin and Curcumin and Other Plant-origin Compounds in Ovarian Cancer Cells – A Mini-review

Basic Studies on Chemopreventive Properties of Quercetin and Curcumin and Other Plant-origin Compounds in Ovarian Cancer Cells – A Mini-review

Targeting Cancer with Nano-Bullets: Curcumin, EGCG, Resveratrol and Quercetin on Flying Carpets

Proposed interaction between angiotensinogen and retinoblastoma tumor suppressor protein: Potential molecular origin of hypertension

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