Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats

Roslan, Josef; Giribabu, Nelli; Karim, Kamarulzaman; Salleh, Naguib

doi:10.1016/j.biopha.2016.12.044

Cited by 118 publications

(88 citation statements)

References 42 publications

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“…The 28 days lasting administration of QCT (10-50 mg/kg) to Sprague Dawley male rats with streptozotocin (STZ)-induced diabetes caused significant decrease of cardiac injury markers levels, particularly troponin-C, creatine kinase-isoenzyme (CK-MB) and lactate dehydrogenase (LDH). In addition, ameliorated histopathological changes, oxidative stress, inflammation and apoptosis levels were observed [103]. In the study of Soman et al [106], it was found that pure QCT (50 mg/kg) as well as extract from Psidium guajava (a plant highly enriched with QCT) showed beneficial effects on the diabetic heart.…”

Section: Role Of Comorbidities In Cardioprotection By Qct and Its Dermentioning

confidence: 95%

Potential Implications of Quercetin and its Derivatives in Cardioprotection

Ferenczyová

Kaločayová

Barteková

2020

IJMS

106

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Quercetin (QCT) is a natural polyphenolic compound enriched in human food, mainly in vegetables, fruits and berries. QCT and its main derivatives, such as rhamnetin, rutin, hyperoside, etc., have been documented to possess many beneficial effects in the human body including their positive effects in the cardiovascular system. However, clinical implications of QCT and its derivatives are still rare. In the current paper we provide a complex picture of the most recent knowledge on the effects of QCT and its derivatives in different types of cardiac injury, mainly in ischemia-reperfusion (I/R) injury of the heart, but also in other pathologies such as anthracycline-induced cardiotoxicity or oxidative stress-induced cardiac injury, documented in in vitro and ex vivo, as well as in in vivo experimental models of cardiac injury. Moreover, we focus on cardiac effects of QCT in presence of metabolic comorbidities in addition to cardiovascular disease (CVD). Finally, we provide a short summary of clinical studies focused on cardiac effects of QCT. In general, it seems that QCT and its metabolites exert strong cardioprotective effects in a wide range of experimental models of cardiac injury, likely via their antioxidant, anti-inflammatory and molecular pathways-modulating properties; however, ageing and presence of lifestyle-related comorbidities may confound their beneficial effects in heart disease. On the other hand, due to very limited number of clinical trials focused on cardiac effects of QCT and its derivatives, clinical data are inconclusive. Thus, additional well-designed human studies including a high enough number of patients testing different concentrations of QCT are needed to reveal real therapeutic potential of QCT in CVD. Finally, several negative or controversial effects of QCT in the heart have been reported, and this should be also taken into consideration in QCT-based approaches aimed to treat CVD in humans.

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Section: Role Of Comorbidities In Cardioprotection By Qct and Its Dermentioning

confidence: 95%

Potential Implications of Quercetin and its Derivatives in Cardioprotection

Ferenczyová

Kaločayová

Barteková

2020

IJMS

106

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“…Recent studies conducted by Roslan, Nelli Giribabu, Karim, and Salleh (2017) demonstrated the ameliorative effect of quercetin against oxidative stress, inflammation, and apoptosis in the heart of STZ-nicotinamide-induced diabetic rats. The cotreatment of quercetin with resveratrol showed a promising antidiabetic potential by maintaining the hepatic glucose metabolic enzymes activity and structure of pancreatic β-cells in STZ-induced diabetic rats (Yang & Kang, 2018).…”

Section: Introductionmentioning

confidence: 99%

Quercetin modulates hyperglycemia by improving the pancreatic antioxidant status and enzymes activities linked with glucose metabolism in type 2 diabetes model of rats: In silico studies of molecular interaction of quercetin with hexokinase and catalase

et al. 2019

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Quercetin was assessed for its antihyperglycemic effect in fructose-streptozotocin (STZ) induced diabetic rats. The oral administration of quercetin at the dosage of 25 and 50 mg/kg for 28 days remarkably reduced the level of blood glucose, glycosylated hemoglobin (Hb), and hepatic glycogen but enhanced plasma Hb concentration. The altered activities of glucose-6-phosphatase and hexokinase in diabetic rats were significantly improved upon quercetin treatment. Furthermore, the antioxidant activity of pancreatic superoxide dismutase, catalase (CAT), and reduced glutathione was effectively increased while the value for thiobarbituric acid reactive species was decreased. A significant reduction of glycemia was observed in the glucose tolerance test, 120 min after the glucose pulse. Also, the damage caused by fructose-STZ in the liver and pancreas of diabetic animals were restored to near normal. Molecular docking of quercetin showed a high affinity for hexokinase and CAT with a binding energy of −7.82 and −9.83 kcal/mol, respectively, more elevated than the standard drugs. Practical applicationsFunctional foods and nutraceuticals have increasingly interested the consumers in terms of health benefits and have started focussing on the prevention or cure of disease by the foods and their health-enhancing phytochemicals. Quercetin is one of the most potent naturally occurring antioxidants within the flavonoid subclasses, mostly distributed as a secondary metabolite in fruits, vegetables, and black tea.Based on the results exhibited in the present study, we proposed that the consumption of foods rich in quercetin could be a cheap and affordable nutraceutical that can be developed for the treatment of T2DM and its complications. Further studies on the safety aspects of quercetin in long-term usage are strongly recommended before implementing for the treatment of human diseases. | MATERIAL S AND ME THODS | Chemicals and reagentsThe compounds 3,5,7,3,4, pentahydroxy flavones (quercetin), STZ, potassium hydroxide (KOH), cyanmethemoglobin, trichloroacetic acid (TCA), sulfuric acid (H 2 SO 4 ), HPLC grade ethanol, potassium chloride (KCl), ethylenediaminetetraacetic acid (EDTA), ammonium molybdate {(NH4) 6 Mo 7 O 24 }, ammonium acetate (NH 4 CH 3 CO 2 ), K E Y W O R D S anti-hyperglycaemic, antioxidant, glucose metabolism, histopathology, molecular docking, Quercetin | 3 of 16 OYEDEMI Et al.amino naphthol sulfonic acid (C 10 H 9 NO 4 S), Tris-HCl buffer, citrate buffer, sucrose, glucose, and Drabkin reagents purchased from Merck Chemicals (Pty) Ltd., Bellville, South Africa. All other chemicals and reagents were of analytical grade and procured from Sigma-Aldrich Chemical Co. (Johannesburg-SA).

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“…It is reported that ferulic acid, quercetin, and rutin, three predominant compounds in GAE (Chao et al., ), could display hypoglycemic effects in diabetic rats (Chowdhury, Ghosh, Rashid, & Sil, ; Roslan, Giribabu, Karim, & Salleh, ). Thus, the observed lower blood glucose level and higher insulin level in our present study could be partially ascribed to the presence of these phytochemicals in GAE.…”

Section: Discussionmentioning

confidence: 99%

Anti‐Diabetic Effects of Gynura Bicolor Aqueous Extract in Mice

Pai

Mong

Yang

et al. 2019

Journal of Food Science

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The effects of Gynura bicolor aqueous extract (GAE) upon glycemic control, coagulation disorder, lipid accumulation, and glycative, oxidative, and inflammatory stresses in diabetic mice were investigated. Mice were treated with streptozotocin to induce type 1 diabetes. Diabetic mice were divided into four groups, consumed GAE at 0%, 0.25%, 0.5%, or 1%. Normal group consumed standard mouse basal diet. After 8‐week treatments, mice were sacrificed after overnight fasting. Results showed that GAE supplement at 0.5% and 1% decreased plasma glucose level and increased plasma insulin level. Diabetes lowered plasma level of protein C and anti‐thrombin III; and raised plasminogen activator inhibitor‐1 activity and fibrinogen level in plasma. GAE supplement at 0.5% and 1% reversed these alterations. Histological data, assayed by Oil Red O stain, indicated that GAE supplement decreased lipid accumulation in liver. GAE supplement at 0.5% and 1% reduced aldose reductase activity in heart and kidney; and lowered the levels of carboxymethyllysine and pentosidine in plasma and two organs. Diabetes decreased glutathione content, and increased reactive oxygen species, interleukin (IL)‐1β, IL‐6, and tumor necrosis factor‐α production in heart and kidney. GAE supplement at three test doses reversed these changes. Diabetes upregulated the mRNA expression of p38 and nuclear factor kappa (NF‐κ)B in heart and kidney. GAE supplement suppressed the mRNA expression of both p38 and NF‐κB. These novel findings suggest that Gynura bicolor is a potent functional food for diabetic prevention or alleviation.

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Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats

Cited by 118 publications

References 42 publications

Potential Implications of Quercetin and its Derivatives in Cardioprotection

Potential Implications of Quercetin and its Derivatives in Cardioprotection

Quercetin modulates hyperglycemia by improving the pancreatic antioxidant status and enzymes activities linked with glucose metabolism in type 2 diabetes model of rats: In silico studies of molecular interaction of quercetin with hexokinase and catalase

Anti‐Diabetic Effects of Gynura Bicolor Aqueous Extract in Mice

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