Quercetin and Coumarin Inhibit Dipeptidyl Peptidase-IV and Exhibits Antioxidant Properties: In Silico, In Vitro, Ex Vivo

Singh, Anand-Krishna; Patel, Pankaj Kumar; Choudhary, Komal; Joshi, Jaya; Yadav, Dhananjay

doi:10.3390/biom10020207

Cited by 50 publications

(42 citation statements)

References 48 publications

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“…The administration of teneligliptin, a DPP-IV inhibitor, results in a variety of beneficial effects including alleviating inflammation and oxidative stress in both the vasculature and PVAT, thus reducing atherosclerosis progression in apolipoprotein E (ApoE) knockout mice [160]. Recently, two polyphenolic compounds (coumarin and quercetin) have been suggested to inhibit DPP-IV [161]; however, further studies are needed to investigate whether polyphenolic compounds may reduce oxidative stress and target DPP-IV in PVAT.…”

Section: Glp-1 and Dpp-ivmentioning

confidence: 99%

Perivascular Adipose Tissue as a Target for Antioxidant Therapy for Cardiovascular Complications

et al. 2020

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Perivascular adipose tissue (PVAT) is the connective tissue surrounding most of the systemic blood vessels. PVAT is now recognized as an important endocrine tissue that maintains vascular homeostasis. Healthy PVAT has anticontractile, anti-inflammatory, and antioxidative roles. Vascular oxidative stress is an important pathophysiological event in cardiometabolic complications of obesity, type 2 diabetes, and hypertension. Accumulating data from both humans and experimental animal models suggests that PVAT dysfunction is potentially linked to cardiovascular diseases, and associated with augmented vascular inflammation, oxidative stress, and arterial remodeling. Reactive oxygen species produced from PVAT can be originated from mitochondria, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, and uncoupled endothelial nitric oxide synthase. PVAT can also sense vascular paracrine signals and response by secreting vasoactive adipokines. Therefore, PVAT may constitute a novel therapeutic target for the prevention and treatment of cardiovascular diseases. In this review, we summarize recent findings on PVAT functions, ROS production, and oxidative stress in different pathophysiological settings and discuss the potential antioxidant therapies for cardiovascular diseases by targeting PVAT.

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Section: Glp-1 and Dpp-ivmentioning

confidence: 99%

Perivascular Adipose Tissue as a Target for Antioxidant Therapy for Cardiovascular Complications

et al. 2020

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“…The synthesis of different organic solvent extracts may differ in quality and concentration depending upon the difference in the polarity of the solvent used for extraction and the extracted polyphenols ( 42 , 43 ). Phenolic compounds such as gallic acid, caffeic acid, ferulic acid, trans-resveratrol, quercetin, fisetin have been shown to act as natural antioxidants by neutralizing free radicals ( 44 , 45 ).…”

Section: Natural Polyphenols: Therapeutics Of Dcmmentioning

confidence: 99%

Pathophysiology, Clinical Characteristics of Diabetic Cardiomyopathy: Therapeutic Potential of Natural Polyphenols

2020

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Diabetic cardiomyopathy (DCM) is an outcome of disturbances in metabolic activities through oxidative stress, local inflammation, and fibrosis, as well as a prime cause of fatality worldwide. Cardiovascular disorders in diabetic individuals have become a challenge in diagnosis and formulation of treatment prototype. It is necessary to have a better understanding of cellular pathophysiology that reveal the therapeutic targets and prevent the progression of cardiovascular diseases due to hyperglycemia. Critical changes in levels of collagen and integrin have been observed in the extracellular matrix of heart, which was responsible for cardiac remodeling in diabetic patients. This review explored the understanding of the mechanisms of how the phytochemicals provide cardioprotection under diabetes along with the caveats and provide future perspectives on these agents as prototypes for the development of drugs for managing DCM. Thus, here we summarized the effect of various plant extracts and natural polyphenols tested in preclinical and cell culture models of diabetic cardiomyopathy. Further, the potential use of selected polyphenols that improved the therapeutic efficacy against diabetic cardiomyopathy is also illustrated.

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“…Furthermore, DPP-IV inhibitors help enhance insulin secretion from β-cells by inhibiting the DPP-IV enzyme and increasing GLP-1 circulation in the body. Recent studies have reported the presence of protease inhibitors, such as alkaloids, flavonoids, glycosides, phenolic acids, polysaccharides, peptidoglycan, glycopeptides, and steroids, that act as DPP-IV inhibitors, along with their antioxidant properties [ 17 , 82 , 83 , 84 , 85 ]. Table 2 presents efficacious DPP-IV inhibitors with its inhibition activity (percentage/IC 50 ) from natural sources, their active parts, and medicinal uses.…”

Section: Mechanism Of Dpp-iv Inhibitors With Antioxidant Potentialmentioning

confidence: 99%

Dipeptidyl Peptidase (DPP)-IV Inhibitors with Antioxidant Potential Isolated from Natural Sources: A Novel Approach for the Management of Diabetes

2021

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Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia that is predominantly caused by insulin resistance or impaired insulin secretion, along with disturbances in carbohydrate, fat and protein metabolism. Various therapeutic approaches have been used to treat diabetes, including improvement of insulin sensitivity, inhibition of gluconeogenesis, and decreasing glucose absorption from the intestines. Recently, a novel approach has emerged using dipeptidyl peptidase- IV (DPP-IV) inhibitors as a possible agent for the treatment of T2DM without producing any side effects, such as hypoglycemia and exhaustion of pancreatic β- cells. DPP-IV inhibitors improve hyperglycemic conditions by stabilizing the postprandial level of gut hormones such as glucagon-like peptide-1, and glucose-dependent insulinotropic polypeptides, which function as incretins to help upregulate insulin secretion and β-cell mass. In this review, we summarized DPP-IV inhibitors and their mechanism of inhibition, activities of those isolated from various natural sources, and their capacity to overcome oxidative stress in disease conditions.

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Quercetin and Coumarin Inhibit Dipeptidyl Peptidase-IV and Exhibits Antioxidant Properties: In Silico, In Vitro, Ex Vivo

Cited by 50 publications

References 48 publications

Perivascular Adipose Tissue as a Target for Antioxidant Therapy for Cardiovascular Complications

Perivascular Adipose Tissue as a Target for Antioxidant Therapy for Cardiovascular Complications

Pathophysiology, Clinical Characteristics of Diabetic Cardiomyopathy: Therapeutic Potential of Natural Polyphenols

Dipeptidyl Peptidase (DPP)-IV Inhibitors with Antioxidant Potential Isolated from Natural Sources: A Novel Approach for the Management of Diabetes

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