Quercetin and its role in modulating endoplasmic reticulum stress: A review

Eisvand, Farhad; Tajbakhsh, Amir; Seidel, Véronique; Zirak, Mohammad Reza; Tabeshpour, Jamshid; Shakeri, Abolfazl

doi:10.1002/ptr.7283

Cited by 30 publications

(14 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among all the flavonoids, glycosides of quercetin are known to have better absorption in the case of humans. It has a rapid metabolism and is excreted without accumulation in the body [45]. Quercetin is mostly absorbed in the small intestine.…”

Section: Onionmentioning

confidence: 99%

Health Benefits of Quercetin in Age-Related Diseases

2022

View full text Add to dashboard Cite

Polyphenols are the known group of phytochemicals that essentially consists of phenolic rings. These are the plant product present in varied fruits and vegetables. These secondary metabolites perform a protective function in plants from environmental and biological stress. When consumed as a human diet these are also known to prevent various age-associated diseases. Polyphenols are known to possess antioxidant properties and protect against oxidative stress. The literature survey was carried out using databases such as PubMed, Science direct and Springer. The research articles from last 10–12 years were selected for this review based on its relevancy with the topic. The articles selected was mainly focused on quercetin and its health benefits. The present review highlights the main functions of a flavonoid, quercetin. Quercetin is among the widely occurring polyphenol, found abundantly in nature. It is commonly present in different plant products. Onion is known to have the highest quantity of quercetin. This plant compound is possessed antioxidant properties and is considered to have a protective function against aging. It is known to be present in both free and conjugated forms. Quercetin has anti-oxidative, anti-inflammatory, anti-proliferative, anti-carcinogenic, anti-diabetic, and anti-viral properties. The molecule is lipophilic and can easily cross the BBB (Blood-Brain Barrier) and hence protects from neurodegenerative diseases. Various in vivo and in vitro studies have demonstrated the role of quercetin and here a detailed review of quercetin as a curative agent in neurodegeneration, diabetes, cancer, and inflammation has been carried out. Studies have proved that quercetin plays a crucial role in the prevention of age-related disorders. Quercetin is a potent antioxidant which is currently being used in various pharmaceuticals. Properties of quercetin can be further explored in various other disorders. Nanoformulations and liposomal formulations of quercetin can be made to treat other age associated diseases.

show abstract

Section: Onionmentioning

confidence: 99%

Health Benefits of Quercetin in Age-Related Diseases

2022

View full text Add to dashboard Cite

show abstract

“…It has a fast metabolic rate and a short half-life in blood, and its bioavailability is low [ 14 ]. Modern pharmacological studies have shown that QUR has anti-oxidation, anti-cancer, anti-allergy, anti-inflammation, anti-obesity and neuroprotection properties and shows an inhibition of platelet aggregation, enhancement of mitochondrial synthesis, regulation of intestinal microorganisms and other functions [ 8 , 9 , 15 ]. QUR can intervene in multiple pathological processes of PCOS through multi-target and multi-pathway and is expected to become a new treatment drug for PCOS.…”

Section: Introductionmentioning

confidence: 99%

Potential Role of Quercetin in Polycystic Ovary Syndrome and Its Complications: A Review

Chen

Fan

et al. 2022

Molecules

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is a common multisystem disease with reproductive, metabolic and psychological abnormalities. It is characterized by a high prevalence rate in women of childbearing age and highly heterogeneous clinical manifestations, which seriously harm women’s physical and mental health. Quercetin (QUR) is a natural compound of flavonoids found in a variety of foods and medicinal plants. It can intervene with the pathologic process of PCOS from multiple targets and channels and has few adverse reactions. It is mentioned in this review that QUR can improve ovulation disorder, relieve Insulin resistance (IR), reduce androgen, regulate lipid metabolism, regulate gut microbiota and improve vascular endothelial function, which is of great significance in the treatment of PCOS.

show abstract

“… 48 The unfolded protein response (UPR), also known as ER stress, is activated when the organism is stimulated by an excessive buildup of misfolded or unfolded proteins. 49 Under normal conditions, ER transmembrane proteins require IRE1, PERK, and ATF6 to form a stable complex with regulatory protein GRP78. After the abnormally excessive accumulation of ER proteins, these proteins dissociate from their corresponding regulatory proteins, thereby activating ER stress pathways, including the PERK/eIF2α/ATF4 pathway.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Zinc Oxide Particles Can Cause Ovarian Toxicity by Oxidative Stress in Female Mice Model

Xu¹,

Zhao²,

Liu³

et al. 2022

IJN

View full text Add to dashboard Cite

Introduction Zinc oxide nanoparticles (ZnO NPs) participate in all aspects of our lives, but with their wide application, more and more disadvantages are exposed. The goal of this study was to investigate the toxicity of ZnO NPs in female mice ovaries and explore its potential mechanism. Methods In this study, adult female mice were orally exposed to 0, 100, 200, and 400 mg/kg ZnO NPs for 7 days. We explored the underlying mechanisms via the intraperitoneal injection of N-acetyl-cysteine (NAC), an inhibitor of oxidative stress, and salubrinal (Sal), an inhibitor of endoplasmic reticulum (ER) stress. Results The results indicated that serum estradiol and progesterone levels declined greatly with increasing ZnO NPs dosage. Hematoxylin and eosin (HE) staining revealed increased atretic follicles and exfoliated follicular granulosa cells. Moreover, at the transcriptional level, antioxidant-related genes such as Keap1 and Nrf2 , and ER stress-related genes PERK, eIF2α , and ATF4 were markedly upregulated. In addition, the expression of Caspase12, Caspase9 , and Caspase3 , which are genes related to apoptosis, was also upregulated in all ZnO NPs treatment groups. Serum malondialdehyde (MDA) content was remarkably up-regulated, whereas superoxide dismutase (SOD) activity was down-regulated. The 400 mg/kg ZnO NPs treatment group suffered the most substantial harm. However, ovarian damage was repaired when NAC and Sal were added to this group. Conclusion ZnO NPs had toxic effects on the ovary of female mice, which were due to oxidative stress, ER stress, and the eventual activation of apoptosis.

show abstract

Quercetin and its role in modulating endoplasmic reticulum stress: A review

Cited by 30 publications

References 82 publications

Health Benefits of Quercetin in Age-Related Diseases

Health Benefits of Quercetin in Age-Related Diseases

Potential Role of Quercetin in Polycystic Ovary Syndrome and Its Complications: A Review

Zinc Oxide Particles Can Cause Ovarian Toxicity by Oxidative Stress in Female Mice Model

Contact Info

Product

Resources

About