Quercetin and Osteoarthritis: A Mechanistic Review on the Present Documents

Samadi, Faezeh; Kahrizi, Mohammad Saeed; Heydari, Fateme; ArefNezhad, Reza; Roghani‐Shahraki, Hossein; Ardekani, Abnoos Mokhtari; Rezaei-Tazangi, Fatemeh

doi:10.1159/000525494

Cited by 16 publications

(11 citation statements)

References 83 publications

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“…Quercetin is a avonoid compound that can exert anti-in ammatory and antioxidant effects in degenerative diseases. After administering quercetin to OA rats, Li et al found that the serum levels of proin ammatory cytokines were signi cantly reduced and that the production of ROS in chondrocytes was signi cantly reduced; furthermore, they con rmed that quercetin exerts these effects through the IRAK1/NLRP3 signalling pathway [31,32].…”

Section: Discussionmentioning

confidence: 99%

Mechanistic study of Huangqi Guizhi Wuwu decoction in the treatment of osteoarthritis using a weighted gene co-expression network and molecular docking techniques

Jiang

Cai

Wang

et al. 2023

Preprint

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Objective: To use weighted gene co-expression network analysis (WGCNA) and molecular docking techniques to predict the mechanism of action of Huangqi Guizhi Wuwu decoction (HGWWD) in the treatment of osteoarthritis (OA) and to provide a bioinformatics basis for the clinical application of HGWWD in the treatment of OA. Methods: After searching the Gene Expression Omnibus (GEO) database, the GSE55235, GSE206848 and GSE55457 datasets were obtained. After merging and normalizing the GSE55235 and GSE206848 datasets, differentially expressed genes (DEGs) were screened, modules closely associated with OA were screened using a weighted gene co-expression network (WGCN) constructed using R software, and the common genes among DEGs and key module genes were imported into the Database for Annotation, Visualization and Integrated Discovery (DAVID) for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. The active ingredients in HGWWD were retrieved through the traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP), and a "drug-active ingredient-target" network was constructed using Cytoscape software. The GSE55457 dataset was used to verify and compare the expression differences in hub genes between different groups. AutoDock was used to conduct molecular docking of key genes and related active ingredients, and PyMOL and Discovery Studio were used for visual analyses. Results: A total of 1455 DEGs were screened in the merged dataset, including 574 upregulated genes and 881 downregulated genes. The key module contained 388 genes. A total of 47 pathways were obtained from the KEGG analysis. β-Sitosterol, kaempferol, β-carotene, stigmasterol, and quercetin were identified as the main compounds of HGWWD, and interleukin (IL)-6, prostaglandin-endoperoxide synthase 2 (PTGS2), vascular endothelial growth factor A (VEGFA), JUN, MYC, NFKBIA, SELE, and chemokine (C-X-C motif) ligand 2 (CXCL2) were the main hub genes involved in the treatment of OA with HGWWD. Molecular docking indicated that except for quercetin, the binding energies of other major compounds to hub genes were less than -5.0 kcal/mol. Conclusion: β-Sitosterol, kaempferol, β-carotene, stigmasterol and quercetin in HGWWD act on MYC, JUN, IL-6, VEGFA, and SELE, thus generating good therapeutic effects in individuals with OA.

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Section: Discussionmentioning

confidence: 99%

Mechanistic study of Huangqi Guizhi Wuwu decoction in the treatment of osteoarthritis using a weighted gene co-expression network and molecular docking techniques

Jiang

Cai

Wang

et al. 2023

Preprint

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“…Structurally, natural flavonoids can be divided into several sub-groups regarding the degree of oxidation in the central heterocycle, mainly including flavonols, flavones, flavanols/catechins, flavanones, anthocyanins, and isoflavones ( 14 ) ( Figure 1 ). Natural flavonoids have been demonstrated to have various biological activities, including anti-inflammation, anti-oxidation, anti-cancer, and bone protection ( 15 ). For example, xanthohumol (40 mg/day by intragastric administration for 8 weeks in mice and 10, 25, and 50 μM for cell culture) may exhibit inhibitory activity against the production of inflammatory cytokines and the expression of ECM catabolic enzymes by upregulating NRF2 and downregulating NF-κB pathways in vivo and in vitro ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

The protective activity of natural flavonoids against osteoarthritis by targeting NF-κB signaling pathway

Zhou

2023

Front. Endocrinol.

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Osteoarthritis (OA) is a typical joint disease associated with chronic inflammation. The nuclear factor-kappaB (NF-κB) pathway plays an important role in inflammatory activity and inhibiting NF-κB-mediated inflammation can be a potential strategy for treating OA. Flavonoids are a class of naturally occurring polyphenols with anti-inflammatory properties. Structurally, natural flavonoids can be divided into several sub-groups, including flavonols, flavones, flavanols/catechins, flavanones, anthocyanins, and isoflavones. Increasing evidence demonstrates that natural flavonoids exhibit protective activity against the pathological changes of OA by inhibiting the NF-κB signaling pathway. Potentially, natural flavonoids may suppress NF-κB signaling-mediated inflammatory responses, ECM degradation, and chondrocyte apoptosis. The different biological actions of natural flavonoids against the NF-κB signaling pathway in OA chondrocytes might be associated with the differentially substituted groups on the structures. In this review, the efficacy and action mechanism of natural flavonoids against the development of OA are discussed by targeting the NF-κB signaling pathway. Potentially, flavonoids could become useful inhibitors of the NF-κB signaling pathway for the therapeutic management of OA.

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“…Studies have shown that natural compounds positively treat and prevent diseases like Alzheimer's, osteoarthritis and inflammatory bowel disease. 14 , 15 , 16 …”

Section: Introductionmentioning

confidence: 99%

“…Thus, adding some new agents to these pharmacological treatments or replacing a new agent with a different mechanism, such as alleviating oxidative stress, may be effective in treating COPD. Studies have shown that natural compounds positively treat and prevent diseases like Alzheimer's, osteoarthritis and inflammatory bowel disease 14–16 …”

Section: Introductionmentioning

confidence: 99%

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Curcumin effects on chronic obstructive pulmonary disease: A systematic review

Safari

Davoodi

Soltani

et al. 2023

Health Science Reports

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Introduction Chronic obstructive pulmonary disease (COPD) is a common disease of the lungs known as the third reason for death worldwide. Frequent COPD exacerbations compel health care workers to apply interventions that are not adverse effect free. Accordingly, adding or replacing Curcumin, a natural meal flavoring, may indicate advantages in this era by its antiproliferative and anti‐inflammatory effects. Methods The PRISMA checklist was employed for the systematic review study. On June 3, 2022, PubMed/Medline, Scopus, and Web of Science were searched for studies associated with COPD and Curcumin in the last 10 years. Duplicate or non‐English publications and articles with irrelevant titles and abstracts were excluded. Also, preprints, reviews, short communications, editorials, letters to the editor, comments, conference abstracts, and conference papers were not included. Results Overall, 4288 publications were found eligible, after the screening, 9 articles were finally included. Among them, one, four, and four in vitro, in vivo, and both in vivo and in vitro research exist respectively. According to the investigations, Curcumin can inhibit alveolar epithelial thickness and proliferation, lessen the inflammatory response, remodel the airway, produce ROS, alleviate airway inflammation, hinder emphysema and prevent ischemic complications. Conclusion Consequently, the findings of the current review demonstrate that Curcumin's modulatory effects on oxidative stress, cell viability, and gene expression could be helpful in COPD management. However, for data confirmation, further randomized clinical trials are required.

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Quercetin and Osteoarthritis: A Mechanistic Review on the Present Documents

Cited by 16 publications

References 83 publications

Mechanistic study of Huangqi Guizhi Wuwu decoction in the treatment of osteoarthritis using a weighted gene co-expression network and molecular docking techniques

Mechanistic study of Huangqi Guizhi Wuwu decoction in the treatment of osteoarthritis using a weighted gene co-expression network and molecular docking techniques

The protective activity of natural flavonoids against osteoarthritis by targeting NF-κB signaling pathway

Curcumin effects on chronic obstructive pulmonary disease: A systematic review

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