Quercetin and rutin exhibit antiamyloidogenic and fibril-disaggregating effects in vitro and potent antioxidant activity in APPswe cells

Inhibition of amyloid fibrillation and cytotoxicity of lysozyme fibrillation products by polyphenols

“…8C and D), could be due to their free radical scavenging properties [40,41]. Although further studies are needed to elucidate the precise mechanism of action, the antioxidative activities of RA and Res appear to be the main cause of protection of cell toxicity in the present study, in accord with previous reports describing contribution of antioxidative properties of these polyphenols on cytotoxicity prevention induced by A␤ fibrillation products [42][43][44], and the similar findings on the effects of some other natural polyphenols [53,[77][78][79]. It is worth noting, however, that inhibition of cytotoxicity of amyloidogenic proteins by polyphenols may be mediated, not only through their antioxidative effects, but also by their anti-amyloidogenic activities [22,42,80], a property which closely depends on their hydrophobic/aromatic interaction capacity with amyloidogenic structures [22].…”

Foliar phenolic compounds of ten wild species of Verbenacea as antioxidants and specific chemomarkers

“…) and epicatechin (EC 50 = 14.33 µg mL -1 ), both reported as phenolic compounds with important antiradical activity (Jiménez-Aliaga et al, 2011;Meng et al, 2015).…”

Effect of natural antioxidants on the aggregation and disaggregation of beta-amyloid

“…Additionally, the use of compounds or extracts inhibiting Aβ aggregation is considered a good approach to the therapy and prevention of AD. For example, flavonoids such as myricetin, quercetin, and kaempferol inhibited Aβ aggregation (exhibited antiamyloidogenic activities) [12][13][14]. Additionally, rosmarinic acid and curcumin are other compounds that inhibit Aβ aggregation efficiently [15,16].…”