Quercetin as a Novel Therapeutic Approach for Lymphoma

Abstract

Lymphoma is a name for malignant diseases of the lymphatic system including Hodgkin’s lymphoma and non-Hodgkin’s lymphoma. Although several approaches are used for the treatment of these diseases, some of them are not successful and have serious adverse effects. Therefore, other effective treatment methods might be interesting. Studies have indicated that plant ingredients play a key role in treating several diseases. Some plants have already shown a potential therapeutic effect on many malignant diseases. Quercetin is a flavonoid found in different plants and could be useful in the treatment of different malignant diseases. Quercetin has its antimalignant effects through targeting main survival pathways activated in tumor cells. In vitro/in vivo experimental studies have demonstrated that quercetin possesses a cytotoxic effect on lymphoid cancer cells. Regardless of the optimum results that have been obtained from both in vitro/in vivo studies, few clinical studies have analyzed the antitumor effects of quercetin in lymphoid cancers. Thus, it seems that more clinical studies should introduce quercetin as a therapeutic, alone or in combination with other chemotherapy agents. Here, in this study, we reviewed the anticancer effects of quercetin and highlighted the potential therapeutic effects of quercetin in various types of lymphoma.

RETRACTED: Quercetin Inhibits Tumorigenesis of Colorectal Cancer Through Downregulation of hsa_circ_0006990

“…Quercetin is a natural bioflavonoid compound extracted from Hippophae rhamnoides, and it can significantly inhibit the progression of multiple cancers. For example, Mohammed et al (2021) found that quercetin induced the apoptosis and inhibited the invasion of breast cancer cells; Soofiyani et al (2021) indicated that quercetin acted as a novel agent for the treatment of lymphoma. Quercetin has also been shown to be able to inhibit the growth of CRC cells ( Qi et al, 2021 ).…”

Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases

“…The specific effect of quercetin on tumor cells without any impact on normal or nontransformed cells has compelled many researchers to explore its potential use as an adjuvant in suppressing proliferation, metastasis, epithelial–mesenchymal transition (EMT), and oxidative stress [ 31 – 33 ]. Having more potent antitumor activity, fewer side effects, and cost-effectiveness, natural products are promising candidates for pharmaceutical development as anticancer agents.…”

Impact of Qi-Invigorating Traditional Chinese Medicines on Diffuse Large B Cell Lymphoma Based on Network Pharmacology and Experimental Validation

“…luteolin, an active ingredient extracted from Codonopsis Radix and Pseudostellariae Radix, has been tested to inhibit the proliferation of classical Hodgkin’s lymphoma cells via caspase activation ( Gharbaran et al, 2020 ). Quercetin, an active ingredient of Astragali Radix and Glycyrrhizae Radix et Rhizoma, has been detected to inhibit cancer cell growth by modulating AKT and NF-κB pathways in lymphoma models ( Soofiyani et al, 2021 ). The experimental results also displayed the prospect of Qi-invigorating herbs in DLBCL treatment.…”