Quercetin Attenuates Ethanol‐Induced Iron Uptake and Myocardial Injury by Regulating the Angiotensin II‐L‐Type Calcium Channel

Guo, Xiaoping; Chen, Man; Zeng, Hongmei; Liu, Peiyi; Zhu, Xinghong; Zhou, Feng; Liu, Jingjing; Zhang, Jun; Dong, Zhiguo; Tang, Yuhan; Gao, Chao; Yao, Ping

doi:10.1002/mnfr.201700772

Cited by 20 publications

(17 citation statements)

References 52 publications

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“…The total RNA of the mice livers were extracted and quantified as previously described . Total RNA was extracted by using TRIzol reagent (Ambion, Life Technologies, Austin, TX, USA).…”

Section: Methodsmentioning

confidence: 99%

Frataxin‐Mediated PINK1–Parkin‐Dependent Mitophagy in Hepatic Steatosis: The Protective Effects of Quercetin

Liu

Lin

et al. 2018

Molecular Nutrition Food Res

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“…The total RNA of the mice livers were extracted and quantified as previously described . Total RNA was extracted by using TRIzol reagent (Ambion, Life Technologies, Austin, TX, USA).…”

Section: Methodsmentioning

confidence: 99%

Frataxin‐Mediated PINK1–Parkin‐Dependent Mitophagy in Hepatic Steatosis: The Protective Effects of Quercetin

Liu

Lin

et al. 2018

Molecular Nutrition Food Res

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“…Elevated intracellular Ca 2+ is involved in the deleterious biochemical and functional changes accompanying MIRI (217). In vitro, quercetin decreased Ca 2+ -dependent cell death when added to H9C2 cardiomyocyte 30 min before application of H 2 O 2 -induced oxidative stress (218). Furthermore, the downstream Ca 2+ activated calpain pathways may lead to contractile dysfunction and cytoskeleton damage (219).…”

Section: Myocardial Protective Effects Of Quercetinmentioning

confidence: 99%

Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases

Dagher

Mury

Thorin‐Trescases

et al. 2021

Front. Cardiovasc. Med.

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The vascular endothelium occupies a catalog of functions that contribute to the homeostasis of the cardiovascular system. It is a physically active barrier between circulating blood and tissue, a regulator of the vascular tone, a biochemical processor and a modulator of coagulation, inflammation, and immunity. Given these essential roles, it comes to no surprise that endothelial dysfunction is prodromal to chronic age-related diseases of the heart and arteries, globally termed cardiovascular diseases (CVD). An example would be ischemic heart disease (IHD), which is the main cause of death from CVD. We have made phenomenal advances in treating CVD, but the aging endothelium, as it senesces, always seems to out-run the benefits of medical and surgical therapies. Remarkably, many epidemiological studies have detected a correlation between a flavonoid-rich diet and a lower incidence of mortality from CVD. Quercetin, a member of the flavonoid class, is a natural compound ubiquitously found in various food sources such as fruits, vegetables, seeds, nuts, and wine. It has been reported to have a wide range of health promoting effects and has gained significant attention over the years. A growing body of evidence suggests quercetin could lower the risk of IHD by mitigating endothelial dysfunction and its risk factors, such as hypertension, atherosclerosis, accumulation of senescent endothelial cells, and endothelial-mesenchymal transition (EndoMT). In this review, we will explore these pathophysiological cascades and their interrelation with endothelial dysfunction. We will then present the scientific evidence to quercetin's anti-atherosclerotic, anti-hypertensive, senolytic, and anti-EndoMT effects. Finally, we will discuss the prospect for its clinical use in alleviating myocardial ischemic injuries in IHD.

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“…Que can relieve cellular impairment caused by calcium overload and can decrease Ca 2+ -dependent cell death when added (1–30 μM) to H9C2 cardiomyocyte 30 mins before application of H 2 O 2 -induced oxidative stress ( Guo et al, 2018 ). Que also inhibited cell death caused by calcium overload by A23187, a free calcium ionophore that can lead to calcium overload, however, without affecting intracellular Ca 2+ concentrations ( Sakanashi et al, 2008 ).…”

Section: Protective Effects Against Calcium Overloadmentioning

confidence: 99%

Protective Mechanisms of Quercetin Against Myocardial Ischemia Reperfusion Injury

Zhang

Wang

2020

Front. Physiol.

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Quercetin has attracted more attention in recent years due to its protective role against ischemia/reperfusion injury. Quercetin can alleviate oxidative stress injury through the inhibition of NADPH oxidase and xanthine oxidase, blockage of the Fenton reaction, and scavenging of reactive oxygen species. Quercetin can also exert anti-inflammatory and anti-apoptotic effects by reducing the response to inflammatory factors and inhibiting cell apoptosis. Moreover, it can induce vasodilation effects through the inhibition of endothelin-1 receptors, the enhancement of NO stimulation and the activation of the large-conductance calcium-activated potassium channels. Finally, Quercetin can also antagonize the calcium overload. These multifaceted activities of Quercetin make it a potential therapeutic alternative for the treatment of ischemia/reperfusion injury.

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Quercetin Attenuates Ethanol‐Induced Iron Uptake and Myocardial Injury by Regulating the Angiotensin II‐L‐Type Calcium Channel

Abstract: Alcohol-induced cardiac injury is associated with excessive NTBI uptake mediated by Ang II-LTCC activation which may be mediated by quercetin against ethanol cardiotoxicity.

Cited by 20 publications

References 52 publications

Frataxin‐Mediated PINK1–Parkin‐Dependent Mitophagy in Hepatic Steatosis: The Protective Effects of Quercetin

Frataxin‐Mediated PINK1–Parkin‐Dependent Mitophagy in Hepatic Steatosis: The Protective Effects of Quercetin

Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases

Protective Mechanisms of Quercetin Against Myocardial Ischemia Reperfusion Injury

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