Quercetin attenuates hypertension induced by sodium fluoride via reduction in oxidative stress and modulation of HSP 70/ERK/PPARγ signaling pathways

Oyagbemi, Ademola Adetokunbo; Omóbòwálé, Temidayo Olutayo; Ola‐Davies, Olufunke Eunice; Asenuga, Ebunoluwa Racheal; Ajibade, Temitayo Olabisi; Adejumobi, Olumuyiwa Abiola; Arojojoye, Oluwatosin Adetola; Afolabi, Jeremiah; Ogunpolu, Blessing Seun; Falayi, Olufunke Olubunmi; Hassan, Fasilat Oluwakemi; Ochigbo, Grace Onyeche; Saba, Adebowale Benard; Adedapo, Adeolu Alex; Yakubu, Momoh Audu

doi:10.1002/biof.1445

Cited by 53 publications

(29 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mounting evidence shows that Que could have protective effects on the heart, brain, kidney, liver, and metabolic diseases by targeting the SIRT1 pathway . Besides, research on the regulation of Que on ERK also exists . However, the roles and mechanisms of Que in INH‐induced liver injury are still unknown.…”

Section: Introductionmentioning

confidence: 99%

Quercetin protected against isoniazide‐induced HepG2 cell apoptosis by activating the SIRT1/ERK pathway

Zhang

Tao

et al. 2019

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Isoniazid (INH) is one of the most commonly used antituberculosis drugs, but its clinical applications have been limited by severe hepatic toxicity. Quercetin (Que), a natural flavonoid, has been proved to have many medicinal properties. This study aimed to clarify the possible protective effects of Que against INH‐induced hepatotoxicity using HepG2 cells. Our results indicated that Que significantly increased cell viability, superoxide dismutase, and GSH levels, while decreased alanine aminotransferase/aspartate aminotransferase levels. Besides, Que significantly abrogated INH‐induced cell apoptosis by upregulating the expression levels of Bcl‐2 and decreasing the levels of Bax, cleaved caspase‐3, and cleaved caspase‐9. Furthermore, Que obviously reversed the inhibition of INH on Sirtuin 1 (SIRT1) expression and extracellular signal‐regulated kinase (ERK) phosphorylation. Next, the SIRT1 inhibitor EX527 blocked the enhancement of Que upon ERK phosphorylation. Notably, EX527 partially abolished the beneficial effects of Que. In brief, our results provided the first evidence that Que protected against INH‐induced HepG2 cells by regulating the SIRT1/ERK pathway.

show abstract

Section: Introductionmentioning

confidence: 99%

Quercetin protected against isoniazide‐induced HepG2 cell apoptosis by activating the SIRT1/ERK pathway

Zhang

Tao

et al. 2019

J Biochem & Molecular Tox

View full text Add to dashboard Cite

show abstract

“…Quercetin exerts its antihypertensive effect by the ability to improve endothelial function, to modulate the renin-angiotensin-aldosterone system (by modulating the mechanism of contraction of smooth muscles in blood vessels) [ 33 ], produces vasodilation at renal level that is protein kinase C-dependent, and lowers blood pressure in patients with diabetes or metabolic syndrome [ 34 , 35 ]. Quercetin also decreases oxidative stress in the heart and kidneys [ 36 ].…”

Section: Classification Of Flavonoidsmentioning

confidence: 99%

“…In vitro studies have been performed based on endothelial denudation, thus demonstrating that the antihypertensive effect of quercetin and kaempferol is dependent on NO synthesized in the endothelium. This theory was proposed as a significant reduction of the vasodilator activity of the two flavonols was observed when using endothelial denudation [ 34 , 35 , 36 ].…”

Section: The Flavonoid’s Mechanism Of Action In Different Pathologmentioning

confidence: 99%

The Effects of Flavonoids in Cardiovascular Diseases

et al. 2020

View full text Add to dashboard Cite

Flavonoids are metabolites of plants and fungus. Flavonoid research has been paid special attention to in recent times after the observation of their beneficial effects on the cardiovascular system. These favorable effects are exerted by flavonoids mainly due to their antioxidant properties, which result from the ability to decrease the oxidation of low-density lipoproteins, thus improving the lipid profiles. The other positive effect exerted on the cardiovascular system is the ability of flavonoids to produce vasodilation and regulate the apoptotic processes in the endothelium. Researchers suggested that these effects, including their anti-inflammatory function, are consequences of flavonoids’ potent antioxidant properties, but recent studies have shown multiple signaling pathways linked to them, thus suggesting that there are more mechanisms involved in the beneficial effect of the flavonoids on the human body. This review aims to present the latest data on the classification of these substances, their main mechanisms of action in the human body, and the beneficial effects on the physiological and pathological status of the cardiovascular system.

show abstract

“…Комбінація раміприлу і корвітину знижувала рівні МА і ДК на тлі зростання активності ферментів АОЗ в усіх досліджуваних органах щурів серії SHR. Такі результати можуть бути наслідком протекторних впливів корвітину на ультраструктуру лівого шлуночка і пов'язані з пригніченням активації металопротеази-2, яка сприяє перебудові і дезорганізації міокарду (Li B. et al, 2016, Oyagbemi, 2018. Механізм кардіопротекції корвітина полягає в активації Akt-кінази, яка бере участь у регуляції проліферації, рості та виживанні клітин (Мойбенко і Пархоменко, 2015(Мойбенко і Пархоменко, , Chen at al., 2020.…”

Section: таблицяunclassified

“…Стимуляція вироблення ендотелієм оксиду азоту за рахунок посилення продукції брадикініну і за рахунок пригнічення оксидативного стресу, викликаного активністю РААС відіграє ключову роль в забезпеченні гомеостазу судинної системи, регулюючи величину просвіту судин, що позначається на позитивній динаміці в перебудові проокисно-антиоксидантних взаємовідносин, в бік зростання активності антиоксидантних ферментів, особливо супероксиддисмутази та каталази. У щурів серії SHR наявна генетично детермінована посилена ниркова продукція ангіотензиногену, яка веде до гіпертензії і ураження нирок (Douros et al, 2013, Monika et al, 2015, Oyagbemi at al., 2018. Раміприл і корвітин сприяє збільшен-A.…”

Section: таблицяunclassified

Зміни Проокисно-Антиоксидантної Системи У Щурів Серії SHR При Лікуванні Гіпотензивними Препаратами (Раміприлом І Кандесартаном) В Комбінації З Корвітином

Marushchak

Rohovyi²,

Савчук

2020

USMYJ

View full text Add to dashboard Cite

Nowadays arterial hypertension (AH) is the most popular cardiovascular disease, which is the most common cause of disability in the population due to high risk of developing complications, such as heart failure, coronary artery disease, stroke. The nature of the morphological manifestations of hypertensive disease depends on the duration and severity, but hypertension triggers a cascade of pathological changes in the lung disease and is accompanied by disruption of the structure of organs that are the most sensitive to fluctuations of blood pressure (brain, heart, kidneys). Continuing the search for new drugs that not only lower blood pressure, but have polytropic effects. In the first place is cardioprotection, which is based on the principles of continuous monitoring of myocardial oxygenation and metabolism. Recently the attention of researchers attract bioflavonoids, such as corvitin, which showed antioxidant, prediabetics, anti-inflammatory properties. The question of influence corvitin in combination therapy with antihypertensive drugs in the treatment of hypertension has been insufficiently studied, that determines the relevance and purpose of our study. Materials and methods. The study was conducted spontaneously hypertensed of rats SHR series. Animals affected into 4 groups of observation. Experienced animal groups series SHR were administered ramipril at a dose of 5 mg / kg, candesartan 4 mg / kg and corvitin a dose of 50 mg/kg, and conducted combined therapy ramipril and corvitin, candesartan and corvitin. Drugs were administered for 7 days. State prooxidative-antioxidant system in the heart, liver, and kidney was estimated by the level of malondialdehyde (MDA) and has a diene conjugates (DC), the background activity of antioxidant enzymes: superoxiddismutase (SOD), glutathione peroxidase (TRP), of catalase (CT). The results of the study. Monotherapy with ramipril exacerbate the pathological process in the examined structures (kidney, heart, liver) and caused a decline in the level of antioxidant enzymes for the same level of malonic aldehyde and diene conjugates. Treatment with candesartan showed a more positive trend in reducing the level of products peroxidation and activation of superoxide dismutase, slightly increased the level of catalase remained unchanged and the activity of glutathione peroxidase. Combination therapy with carnitin significantly changed the indicators oxidative-antioxidant homeostasis in the direction of growth of activity of enzymes catalase and superoxide dismutase on the background of significant decrease of the products of barbituric acid. The most marked improvement was noted in the myocardium of the left ventricle and kidney in combination therapy with candesartan and corvitin. Conclusions. Application of corvitin in combination with antihypertensive drugs demonstrated protective effect. Increased level of blood pressure not only positive dynamics of combination therapy but also pleiotropy effect of corvitin.

show abstract

Quercetin attenuates hypertension induced by sodium fluoride via reduction in oxidative stress and modulation of HSP 70/ERK/PPARγ signaling pathways

Cited by 53 publications

References 65 publications

Quercetin protected against isoniazide‐induced HepG2 cell apoptosis by activating the SIRT1/ERK pathway

Quercetin protected against isoniazide‐induced HepG2 cell apoptosis by activating the SIRT1/ERK pathway

The Effects of Flavonoids in Cardiovascular Diseases

Зміни Проокисно-Антиоксидантної Системи У Щурів Серії SHR При Лікуванні Гіпотензивними Препаратами (Раміприлом І Кандесартаном) В Комбінації З Корвітином

Contact Info

Product

Resources

About