Quercetin attenuates, indomethacin-induced acute gastric ulcer in rats

Al-Kushi, Abdullah G.; ElSawy, Naser A.

doi:10.5603/fm.a2016.0067

Cited by 46 publications

(26 citation statements)

References 58 publications

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“…Hence, many synthetic antiulcer drugs (e.g., misoprostol) have been developed that can be specifically used for preventing or treating NSAID-induced gastric ulcers. But usage of these drugs has been limited due to many side effects (Alkushi & Elsawy, 2017). Therefore, there is a renewed interest in nontoxic, natural antiulcer herbal formulations from medicinal plants (Repetto & Llesuy, 2002).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effect of quercetin treatment on CYP2C9 enzyme activity of diclofenac in healthy human volunteers

Bedada

Prasad

2017

Phytotherapy Research

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The purpose of present study was to evaluate the effect of quercetin on pharmacokinetics of diclofenac sodium (DIC) in healthy volunteers. The open-label, 2 period, sequential study was conducted in 12 healthy volunteers. DIC 100 mg was administered during control and after quercetin phases. Quercetin 500 mg was administered twice daily for 10 days during quercetin phase. Treatment with quercetin significantly enhanced maximum plasma concentration (C ) area under the curve (AUC ), and half life, while significantly decreased elimination rate constant (k ) and apparent oral clearance (CL/F) of DIC compared with control. On the other hand, C and AUC of 4-hydroxydiclofenac (4-OHDIC) were decreased after quercetin treatment. In addition, geometric mean ratios and 90% confidence intervals for C and AUC of DIC and 4-OHDIC were both out of the no-effect limits of 0.80-1.25, which indicates a significant pharmacokinetic interaction between quercetin and DIC. Furthermore, quercetin treatment significantly decreased metabolic ratios of C and AUC suggesting that reduced formation of DIC to 4-OHDIC. The results suggest that quercetin might have inhibited CYP2C9-mediated metabolism of DIC. Accordingly, caution should be taken when quercetin is used in combination with therapeutic drugs metabolized by CYP2C9, and dose adjustment of CYP2C9 substrates may be necessary.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the effect of quercetin treatment on CYP2C9 enzyme activity of diclofenac in healthy human volunteers

Bedada

Prasad

2017

Phytotherapy Research

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“…Alkushi and Elsawy [43] cited that QU has antioxidant property and can protect gastric mucosa against indomethacin-induced GU.…”

Section: Discussionmentioning

confidence: 99%

Quercetin and Ellagic Acid in Gastric Ulcer Prevention: An Integrated Scheme of the Potential Mechanisms of Action From in Vivo Study

Kotob

Sayed

Mohamed

et al. 2018

Asian J Pharm Clin Res

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Objective: The present study was initiated to describe the gastroprotective role of quercetin (Qu) and ellagic acid (EA) on aspirin-induced gastric ulcer (GU) in rats.Methods: Forty adult female albino rats of Wistar strain were distributed into: Control group, GU group, Omeprazole group, Qu group, and EA group. Gross examination, biochemical analyses including serum adrenocorticotropic hormone (ACTH), serotonin (ST), ferritin, heme oxygenase-1 (HO-1), interleukin-2 (IL-2), advanced glycosylation end products (AGEs), and fibronectin (FN) levels were estimated. Moreover, histopathological and histochemical examinations of stomach tissue samples were carried out.Results: Gross examination of gastric mucosa of rats in GU group revealed hyperemia of the stomach mucosa. Furthermore, rats in GU group experienced a significant rise in serum ACTH, ferritin, HO-1, IL-2 and AGEs levels accompanied with significant drop in serum ST and FN levels versus control counterparts. Pre-treatment of GU group with Omeprazole, Qu or EA caused marked improvement in the measured biochemical parameters. Histopathological and histochemical examinations of stomach tissue samples documented the protective action of Omeprazole, Qu and EA with different degrees against GU caused by aspirin. Conclusion:As a conclusion to this study, we can state that both Qu and EA have gastroprotective effect against aspirin-induced GU in rat model. Of note, Qu showed superior impact than EA as an antiulcer agent in this study. The corresponding mechanisms are speculated to be associated with inhibiting stress-induced gastric lesion, attenuating the oxidative stress, iron chelation and blunting ferritin level, modulating inflammatory cascade, and promoting the healing process.

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“…Herbal medicine for gastric ulcers (preventive and/or curative actions) uses products containing mucilage (carrageenan, Malvae flos, Plantago herba) or glycyrrhetinic acid derivatives (Liquiritiae radix) whose structure was the basis of conception of carbenoxolone [9,22]. There are currently few studies on the antiulcer action of flavonoids (luteolin, hyperoside) [4,16] polyphenols (paeniflorine, albiflorine), and phenolcarboxylic acids (chlorogenic acid, caffeic acid, rosmarinic acid) [3,43,56]. To quantify these effects on the decrease in gastric secretion and the increase in defence factors (endogenous prostaglandins), numerous studies have evaluated extracts standardized in phytocompounds [28]; thus, various methods of producing experimental ulcers have been developed -by ligation of the pylorus, by administration of reserpine, indomethacin or HCl/ethyl alcohol or by induction of stress ulcer; in all cases, the experimental animal used is preferably the rat.…”

Section: Introductionmentioning

confidence: 99%

Study of the Potential Antiulcerous Action of Hydroalcoholic Extracts From Prunella Vulgaris L. Of Romanian Origin

Groşan¹

2020

FARMACIA

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Prunella vulgaris L. (Lamiaceae family) species is widespread throughout the world and the fruit-spike is used in folk medicine in many countries. The Romanian resource of Prunellae spica is poorly studied from a phytochemical and pharmacological point of view; accordingly, the present study aimed to evaluate the anti-ulcer action of a hydroalcoholic extract of this species with standardized polyphenol content. The extracts used were phytochemically characterized by the total polyphenol content (TPC) and by the determination of the constituents (phenol-carboxylic acids, flavonoids) by HPLC-MS/MS. Quantitative analysis showed the presence of flavonoids in glycosidic form in fairly large quantities (hyperoside, rutoside, isoquercitrin); on the other hand, smaller quantities of aglycones (quercetol, kaempferol, apigenin) were identified and quantified. Moreover, phenolcarboxylic acids, such as caftaric, ferulic, p-coumaric acid, were measured. Two types of doses (high dose-50 mg/kg body weight (kgbw), respectively low dose 10 mg/ kgbw, values expressed in gallic acid equivalents) were administered preventively/curatively in rats with phenylbutazone-induced ulcer; ranitidine at 50 mg/kgbw was used as an activity control. Efficacy was quantified by measuring ulcer index, as well as by examination of gross features and histopathological changes. The hydroalcoholic extracts of Prunella vulgaris L. proved to have a dose-dependent antiulcerous action in curative treatment. As the titratable acidity is not decreased by the treatment, the effect is mediated by the prevention of oxidative inflammation of the mucosa. Histopathological results confirmed these in vivo results. Prunellae spica of Romanian origin is a plant resource rich in polyphenols that has shown protective effects on nonsteroidal anti-inflammatory drugs (NSAID)-related gastric ulcer. The observed effects are dose-dependent, probably mediated by inhibition of oxidative stress in the mucosa and promotion of regeneration processes. Rezumat Specia Prunella vulgaris L. (Lamiaceae) este răspândită în întreaga lume, iar fructul este folosit în medicina populară în multe țări. Resursa românească de Prunellae spica este puțin studiată din punct de vedere fitochimic și farmacologic, în consecință, prezentul studiu a avut ca scop evaluarea acțiunii anti-ulceroase a unui extract hidroalcoolic din această specie cu conținut standardizat de polifenoli. Extractele utilizate au fost caracterizate fitochimic prin conținutul total de polifenoli (TPC) și prin determinarea constituenților (acizi fenol-carboxilici, flavonoizi) prin HPLC-MS/MS. Analiza cantitativă a arătat prezența flavonoidelor în formă glicozidică în cantități mari (hiperozid, rutozid, izoquercitrin), pe de altă parte, au fost identificate și cuantificate cantități mai mici de agliconi (quercetol, kaempferol, apigenină). Mai mult, au fost cuantificați acizii fenol-carboxilici, ca acidul caftaric, ferulic, p-cumaric. Două tipuri de doze (doză mare-50 mg/kgc, respectiv doză mică 10 mg/kgc, valori exprimate în ech...

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Quercetin attenuates, indomethacin-induced acute gastric ulcer in rats

Abstract: (Folia Morphol 2017; 76, 2: 252-261)

Cited by 46 publications

References 58 publications

Evaluation of the effect of quercetin treatment on CYP2C9 enzyme activity of diclofenac in healthy human volunteers

Evaluation of the effect of quercetin treatment on CYP2C9 enzyme activity of diclofenac in healthy human volunteers

Quercetin and Ellagic Acid in Gastric Ulcer Prevention: An Integrated Scheme of the Potential Mechanisms of Action From in Vivo Study

Study of the Potential Antiulcerous Action of Hydroalcoholic Extracts From Prunella Vulgaris L. Of Romanian Origin

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