Quercetin Beneficial Role in the Homeostatic Variation of Certain Trace Elements in Dyslipidemic Mice

Муселин, Флорин; Cristina, Romeo Teodor; Dumitrescu, Eugenia; Doma, Alexandru O.; Radulov, Isidora; Berbecea, Adina; Horablaga, Adina; Morariu, Florica; Manea, D.; HORABLAGA, Nicolae Marinel

doi:10.1155/2022/3299505

Cited by 4 publications

(1 citation statement)

References 43 publications

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“…According to the current findings, it was noted that QE applied to prevent Cd-induced dyslipidemia improved the serum lipid profile, albeit limited, by showing a hypolipidemic effect (Figure 3). Various studies have reported that QE partially normalizes dyslipidemia, exerts a hypolipidemic effect and can reduce liver fat accumulation (Jeong et al 2012;Tang et al 2012;Muselin et al 2022). It is thought that the ability of QE to ameliorate dyslipidemia may be due to the attenuation of peroxisome proliferator-activated receptor-α (PPAR-α), sterol regulatory element-binding protein-1c (SREBP-1c), and reduction of acetyl-CoA carboxylase in the liver (Gnoni et al 2009;Kobori et al 2011;Hosseini et al 2021).…”

Section: Discussionmentioning

confidence: 99%

Quaercetin Improves Renal Functional Disorder and Dyslipidemia Caused by Acute Cadmium Exposure

Hatipoğlu¹,

ÖZSAN

Kısadere

et al. 2023

Manas Journal of Agriculture Veterinary and Life Sciences

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Heavy metal toxicity and bioaccumulation caused severe damage to soil, water and environment as a result of industrialization/urbanization activities in developing and developed countries. This damage has affected different trophic levels including plants, animals and humans and has become a global concern. The use of various phytonutrients such as Quercetin (QE) has increased in recent years to avoid toxicity caused by heavy metals. Among different heavy metals, cadmium (Cd) toxicity is a major issue in the countries. Cd is a toxic heavy metal that can damage the kidneys and cause dysregulation in many lipid metabolic pathways. However, the number of studies on renal dysfunction and dyslipidemia caused by Cd is limited. We found that Cd causes renal dysfunction and dyslipidemia, and QE ameliorates these Cd-induced damages. Our results showed that Cd increased urea, uric acid, creatnine, alkene phosphatase (ALP), total bilirubin (TBIL) levels compared to the control group, while QE improved other parameters except TBIL. In addition, our findings showed that Cd increased total glyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL) and lactate dehydrogenase (LDH) levels and decreased high-density lipoprotein (HDL) levels. It was noted that QE tended to improve this dyslipidemia picture. The data presented here demonstrated that QE has a clear protective role against dyslipidemia and renal function against Cd toxicity through its hypolipidemic and antioxidative action.

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Section: Discussionmentioning

confidence: 99%

Quaercetin Improves Renal Functional Disorder and Dyslipidemia Caused by Acute Cadmium Exposure

Hatipoğlu¹,

ÖZSAN

Kısadere

et al. 2023

Manas Journal of Agriculture Veterinary and Life Sciences

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Post-traumatic stress disorder and metabolic syndrome: the role of some antioxidants in treatment

Serhiyenko,

Oliinyk,

Pavlovskiy

et al. 2024

Mìžnarodnij endokrinologìčnij žurnal

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The basis for the pathogenesis of cardiovascular, cancer, metabolic diseases, low-grade chronic inflammation (LGCI) and many other disorders is an imbalance between prooxidants and the antioxidant defense system. It is believed that the link between post-traumatic stress disorder (PTSD) and metabolic syndrome (MetS) is based on oxidative stress (OS), increased autonomic nervous system activity, glucocorticoid synthesis activation, or immunological dysregulation. Moreover, pathophysiological changes in the systemic LGCI pathways that result from modifications in glucocorticoid receptor reactivity (secondary to emotional and physiological arousal) may be the basis for inappropriate social behavior consistent with PTSD and MetS manifestations. Recently, evidence has emerged suggesting that a combination of high levels of systemic OS and activation of LGCI plays an important role in the pathogenesis of PTSD. On the other hand, PTSD is a type of recurrent and long-term trauma that exacerbates OS and accelerates cellular aging. LGCI is accompanied by the release of reactive oxygen and nitrogen species, proinflammatory cytokines, and other biologically active substances that cause OS. The purpose of this review was to discuss the role of individual antioxidants, in particular polyphenols, flavonoids, carotenoids, N-acetylcysteine, melatonin, L-arginine, C and E vitamins, zinc, copper, and selenium, in the prevention/treatment of comorbid pathology of PTSD and MetS, as well as to analyze new trends and directions for future research. The search was conducted in Scopus, Science Direct (from Elsevier) and PubMed, including MEDLINE databases. The keywords used were “post-traumatic stress disorder,” “metabolic syndrome,” and “antioxidants.” To identify research results that could not be found during the online search, a manual search of the bibliography of publications was used.

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High Hydrostatic Pressure Treatments Improved Properties of Fermentation of Apple Juice Accompanied by Higher Reserved Lactobacillus plantarum

Jing

Wang

Zhao

et al. 2023

Foods

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This study aimed to assess the feasibility of high hydrostatic pressure (HHP) treatment to obtain high quality juice, and prepared functional apple juice using fermentation technology. The physicochemical properties of HHP (10 min) pasteurized and pasteurized (85 °C, 15 min) apple juices were compared during fermentation. Moreover, the survival of Lactobacillus plantarum after fermentation under simulated gastrointestinal conditions was evaluated. Results showed that HHP-treated apple juice had better properties than that of pasteurized in terms of color difference, total phenol content, and antioxidant activity. After fermentation, about 2.00 log CFU/mL increase in viability of cells was observed and there was around 0.8 reduction in pH value, and the antioxidant capacities were also significantly improved. Additionally, the content of caffeic acid, ferulic acid, and chlorogenic acid significantly increased after 24 h of fermentation. The survival of Lactobacillus plantarum in simulated gastric fluid reached 97.37% after fermentation. Overall, HHP treatment is expected to be a substitute technology to pasteurization in order to obtain higher quality fermented fruit juice. This study could also be helpful for exploitation of fermented juice.

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Quercetin Beneficial Role in the Homeostatic Variation of Certain Trace Elements in Dyslipidemic Mice

Cited by 4 publications

References 43 publications

Quaercetin Improves Renal Functional Disorder and Dyslipidemia Caused by Acute Cadmium Exposure

Quaercetin Improves Renal Functional Disorder and Dyslipidemia Caused by Acute Cadmium Exposure

Post-traumatic stress disorder and metabolic syndrome: the role of some antioxidants in treatment

High Hydrostatic Pressure Treatments Improved Properties of Fermentation of Apple Juice Accompanied by Higher Reserved Lactobacillus plantarum

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