Quercetin functionalized hybrid electrospun nanofibers for wound dressing application

Karuppannan, Sathish Kumar; Dowlath, Mohammed Junaid Hussain; Ramalingam, Raghavendra; Musthafa, Shazia Anjum; Ganesh, Munuswamy Ramanujam; Chithra, V.; Ravindran, Balasubramani; Arunachalam, Kantha Deivi

doi:10.1016/j.mseb.2022.115933

Cited by 12 publications

(6 citation statements)

References 58 publications

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“…53 These features have led quercetin to be extensively used as an antioxidant agent in wound dressing applications. 54 One of the primary challenges associated with utilizing quercetin in wound dressings is its limited solubility. In this study, we addressed this limitation by enhancing the solubility of quercetin through inclusion complexation with HP-β-CD and HP-γ-CD.…”

Section: Tga Analysismentioning

confidence: 99%

Antibacterial, Anti-Inflammatory, and Antioxidant Cotton-Based Wound Dressing Coated with Chitosan/Cyclodextrin–Quercetin Inclusion Complex Nanofibers

Alishahi,

Xiao,

Kreismanis

et al. 2024

ACS Appl. Bio Mater.

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Quercetin, recognized for its antioxidant, antiinflammatory, and antibacterial properties, faces limited biomedical application due to its low solubility. Cotton, a preferred wound dressing material over synthetic ones, lacks inherent antibacterial and wound-healing attributes and can benefit from quercetin features. This study explores the potential of overcoming these challenges through the inclusion complexation of quercetin with cyclodextrins (CDs) and the development of a nanofibrous coating on a cotton nonwoven textile. Hydroxypropyl-beta-cyclodextrin (HP-β-CD) and hydroxypropyl-gamma-cyclodextrin (HP-γ-CD) formed inclusion complexes of quercetin, with chitosan added to enhance antibacterial properties. Phase solubility results showed that inclusion complexation can enhance quercetin solubility up to 20 times, with HP-γ-CD forming a more stable inclusion complexation compared with HP-β-CD. Electrospinning of the nanofibers from HP-β-CD/Quercetin and HP-γ-CD/Quercetin aqueous solutions without the use of a polymeric matrix yielded a uniform, smooth fiber morphology. The structural and thermal analyses of the HP-β-CD/Quercetin and HP-γ-CD/Quercetin nanofibers confirmed the presence of inclusion complexes between quercetin and each of the CDs (HP-β-CD and HP-γ-CD). Moreover, HP-β-CD/Quercetin and HP-γ-CD/Quercetin nanofibers showed a near-complete loading efficiency of quercetin and followed a fastreleasing profile of quercetin. Both HP-β-CD/Quercetin and HP-γ-CD/Quercetin nanofibers showed significantly higher antioxidant activity compared to pristine quercetin. The HP-β-CD/Quercetin and HP-γ-CD/Quercetin nanofibers also showed antibacterial activity, and with the addition of chitosan in the HP-γ-CD/Quercetin system, the Chitosan/HP-γ-CD/Quercetin nanofibers completely eliminated the investigated bacteria species. The nanofibers were nontoxic and well-tolerated by cells, and exploiting the quercetin and chitosan anti-inflammatory activities resulted in the downregulation of IL-6 and NO secretion in both immune as well as regenerative cells. Overall, CD inclusion complexation markedly enhances quercetin solubility, resulting in a biofunctional antioxidant, antibacterial, and anti-inflammatory wound dressing through a nanofibrous coating on cotton textiles.

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Section: Tga Analysismentioning

confidence: 99%

Antibacterial, Anti-Inflammatory, and Antioxidant Cotton-Based Wound Dressing Coated with Chitosan/Cyclodextrin–Quercetin Inclusion Complex Nanofibers

Alishahi,

Xiao,

Kreismanis

et al. 2024

ACS Appl. Bio Mater.

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“…Loading the bioactive natural product to either the combined polymers or to only one of them eliminates this problem. Bioactive materials such as curcumin (Lüer et al 2012;Tejada et al 2016), quercetin (Choudhary et al 2020;Karuppannan et al 2022), rutin (Zhou et al 2021), bromelain (Kalalinia et al 2021), thymoquinone, gentiopicroside (Almukainzi M. et al 2022Almukainzi May et al 2022), hesperidin (Carvalho et al 2021), and others were reported to enhance wound healing by adding them to bio-or synthetic polymers or both.…”

Section: Bio-and Synthetic Polymers Of Bioactive Substances From Natu...mentioning

confidence: 99%

The wound healing effect of botanicals and pure natural substances used in in vivo models

El-Sherbeni

Negm

2023

Inflammopharmacol

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Repairing the wound is a multistep process that includes the spatial and temporal synchronization of a different range of cell types to increase the speed of wound contraction, the proliferation of epithelial cells, and collagen formation. The need for proper management of acute wounds to be cured and not turned into chronic wounds is a significant clinical challenge. The traditional practice of medicinal plants in many regions of the world has been used in wound healing since ancient times. Recent scientific research introduced evidence of the efficacy of medicinal plants, their phyto-components, and the mechanisms underlying their wound-repairing activity. This review aims to briefly highlight the wound-curing effect of different plant extracts and purely natural substances in excision, incision, and burn experimental animal models with or without infection of mice, rats (diabetic and nondiabetic), and rabbits in the last 5 years. The in vivo studies represented reliable evidence of how powerful natural products are in healing wounds properly. They have good scavenging activity against Reactive oxygen species (ROS) and anti-inflammatory and antimicrobial effects that help in the process of wound healing. It is evident that incorporating bioactive natural products into wound dressings of bio- or synthetic polymers in nanofiber, hydrogel, film, scaffold, and sponge forms showed promising results in different phases of the wound-curing process of haemostasis, inflammation, growth, re-epithelialization, and remodelling.

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“…It exhibits a broad spectrum of antibacterial properties, with mechanisms that involve enhancing cell permeability, disrupting the cell wall, and inhibiting protein and nucleic acid synthesis. 93,94 Moreover, quercetin has been confirmed as a long-acting anti-inflammatory agent, holding significant promise in the treatment of inflammatory-induced diseases. 94 The anti-inflammatory effect of quercetin also positions it as a potential agent for cardiovascular protection, including the alleviation of hypertension, ischemiareperfusion injury, and cardiotoxicity.…”

Section: Salvianolic Acidmentioning

confidence: 99%

“…Quercetin, a commercially available flavonoid compound commonly extracted from vegetables, has been extensively investigated for its potential in various disease treatments. It exhibits a broad spectrum of antibacterial properties, with mechanisms that involve enhancing cell permeability, disrupting the cell wall, and inhibiting protein and nucleic acid synthesis 93,94 . Moreover, quercetin has been confirmed as a long‐acting anti‐inflammatory agent, holding significant promise in the treatment of inflammatory‐induced diseases 94…”

Section: Components For Engineering Polyphenol‐based Assembliesmentioning

confidence: 99%

Assembled polyphenol‐based systems as advanced therapeutics

Liu,

Pan,

Shi

et al. 2023

Journal of Polymer Science

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Polymeric assemblies have emerged as a kind of promising platform in biomedical fields. The strong potency of polyphenols to form versatile interactions with other small or polymeric molecules via covalent and noncovalent linkages enables polyphenols to serve as molecular glues, offering a magic driving force to assemble multiple functional molecules into a diversity of polyphenol‐based systems, such as nanoparticles and hydrogels. Due to the unique merits of anti‐tumor, anti‐bacterial, antioxidant, anti‐inflammatory, and cardioprotective properties of polyphenols, polyphenol‐based systems hold great promise to deal with a wide spectrum of diseases. This review comprehensively overviews the components, intermolecular interactions, and preparation methods implicated in the assembly of polyphenol‐based systems. In addition, their medical applications are introduced, particularly the treatments of various diseases, such as tumors, bacterial infections, inflammatory bowel disease (IBD), cardiovascular diseases (CVDs), chronic periodontitis, acute lung injury, osteoarthritis, and renal fibrosis.

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Quercetin functionalized hybrid electrospun nanofibers for wound dressing application

Cited by 12 publications

References 58 publications

Antibacterial, Anti-Inflammatory, and Antioxidant Cotton-Based Wound Dressing Coated with Chitosan/Cyclodextrin–Quercetin Inclusion Complex Nanofibers

Antibacterial, Anti-Inflammatory, and Antioxidant Cotton-Based Wound Dressing Coated with Chitosan/Cyclodextrin–Quercetin Inclusion Complex Nanofibers

The wound healing effect of botanicals and pure natural substances used in in vivo models

Assembled polyphenol‐based systems as advanced therapeutics

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