Quercetin improves high‐fat diet‐induced obesity by modulating gut microbiota and metabolites in C57BL/6J mice

Su, Lijie; Zeng, Yupeng; Li, Guokun; Chen, Jing; Chen, Xiaoyi

doi:10.1002/ptr.7575

Cited by 33 publications

(19 citation statements)

References 76 publications

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“…Quercetin was more abundant in CF than in UF and it was reported that it could improve gut microbial disorders and affect the production of gut microbial metabolites related to oxidative stress. 71 The abundance of Bacteroides in the CF group was lower than that in the UF group, and the abundance of Roseburia in the CF group was higher than that in the UF group, likely owing to the increased naringin in CF. 72,73 Furthermore, proanthocyanin B1 increased after fermentation, and proanthocyanins can protect gut microbiota from perturbation.…”

Section: Papermentioning

confidence: 82%

Lactobacillus co-fermentation of Cerasus humilis juice alters chemical properties, enhances antioxidant activity, and improves gut microbiota

Li¹,

Chen²,

Guo³

et al. 2023

Food Funct.

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Section: Papermentioning

confidence: 82%

Lactobacillus co-fermentation of Cerasus humilis juice alters chemical properties, enhances antioxidant activity, and improves gut microbiota

Li¹,

Chen²,

Guo³

et al. 2023

Food Funct.

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“…Its anti-obesity effect is due to the inhibition of adipogenesis by inhibiting the gene expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) 30 . Quercetin is reported to significantly alleviate high-fat-diet-induced obesity and influence the production of metabolites linked to obesity-related inflammation and oxidative stress by regulating gut microbiota and metabolites 31 . EGCG is a bioactive polyphenol with antioxidant and antiinflammatory effects 32 .…”

Section: Discussionmentioning

confidence: 99%

Identification of hub genes and candidate herbal treatment in obesity through integrated bioinformatic analysis and reverse network pharmacology

Tai

Yang²,

Feng³

et al. 2022

Sci Rep

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Obesity is a global epidemic elevating the risk of various metabolic disorders. As there is a lack of effective drugs to treat obesity, we combined bioinformatics and reverse network pharmacology in this study to identify effective herbs to treat obesity. We identified 1011 differentially expressed genes (DEGs) of adipose tissue after weight loss by analyzing five expression profiles (GSE103766, GSE35411, GSE112307, GSE43471, and GSE35710) from the Gene Expression Omnibus (GEO) database. We identified 27 hub genes from the protein–protein interaction (PPI) network by performing MCODE using the Search Tool for the Retrieval of Interacting Genes (STRING) database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses revealed that these hub genes have roles in the extracellular matrix–receptor interaction, cholesterol metabolism, PI3K-Akt signaling pathway, etc. Ten herbs (Aloe, Portulacae Herba, Mori Follum, Silybum Marianum, Phyllanthi Fructus, Pollen Typhae, Ginkgo Semen, Leonuri Herba, Eriobotryae Folium, and Litseae Fructus) targeting the nine hub genes (COL1A1, MMP2, MMP9, SPP1, DNMT3B, MMP7, CETP, COL1A2, and MUC1) using six ingredients were identified as the key herbs. Quercetin and (-)-epigallocatechin-3-gallate were determined to be the key ingredients. Lastly, Ingredients-Targets, Herbs-Ingredients-Targets, and Herbs-Taste-Meridian Tropism networks were constructed using Cytoscape to elucidate this complex relationship. This study could help identify promising therapeutic targets and drugs to treat obesity.

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“…Moreover, in vivo and in vitro studies have found that CAPE can inhibit the differentiation of mouse preadipocytes and prevent adipogenesis (30,31), and its specific mechanism will be discussed in the next chapter. In addition to phenolic acids, flavonoids, such as chrysin, galangin, apigenin and quercetin, exhibit excellent antiobesity effects through different mechanisms (32)(33)(34)(35).…”

Section: Poplar-type Propolismentioning

confidence: 99%

Propolis polyphenols: A review on the composition and anti-obesity mechanism of different types of propolis polyphenols

Zhu

Zhang²,

Yang³

et al. 2023

Front. Nutr.

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Obesity, one of the most common nutritional diseases worldwide, can lead to dyslipidemia, high blood sugar, high blood pressure, and inflammation. Some drugs have been developed to ameliorate obesity. However, these drugs may cause serious side effects. Therefore, there is an urgent need for alternative “natural” remedies including propolis. Studies have found that propolis has excellent anti-obesity activity in in vitro and in vivo models during the past decades, of which polyphenols are the key component in regulating weight loss. This review focused on the different polyphenol compositions of propolis from different regions and plants, the evidence for the anti-obesity effects of different types of propolis and its derivatives, discussed the impact of propolis polyphenols on obesity related signal pathways, and proposed the molecular mechanism of how propolis polyphenols affect these signal pathways. For example, propolis and its derivatives regulate lipid metabolism related proteins, such as PPARα, PPARγ, SREBP-1&2, and HMG CoA etc., destroy the formation of CREB/CRTC2 transcription complex, activate Nrf2 pathway or inhibit protein kinase IKK ε/TBK1, thereby affecting fat production and lipid metabolism; The effects of propolis on adipokines (adiponectin, leptin and inflammatory factors) were discussed. Additionally, the mechanism of polyphenols in propolis promoting the browning of adipose tissues and the relationship between intestinal microorganisms was summarized. These information may be of value to better understand how specific propolis polyphenols interact with specific signaling pathways and help guide the development of new drugs to combat obesity and related metabolic diseases.

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Quercetin improves high‐fat diet‐induced obesity by modulating gut microbiota and metabolites in C57BL/6J mice

Cited by 33 publications

References 76 publications

Lactobacillus co-fermentation of Cerasus humilis juice alters chemical properties, enhances antioxidant activity, and improves gut microbiota

Lactobacillus co-fermentation of Cerasus humilis juice alters chemical properties, enhances antioxidant activity, and improves gut microbiota

Identification of hub genes and candidate herbal treatment in obesity through integrated bioinformatic analysis and reverse network pharmacology

Propolis polyphenols: A review on the composition and anti-obesity mechanism of different types of propolis polyphenols

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