Quercetin in Tartary Buckwheat Induces Autophagy against Protein Aggregations

Ikari, Sumiko; Lu, Shiou-Ling; Liu, Yuancai; Hao, Feike; Tong, Guoqiang; Lu, Shiguang; Noda, Tetsuji

doi:10.3390/antiox10081217

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…Recently, chaperonin-containing TCP-1 subunit 2 (CCT2) has been identified as novel receptor for solid protein aggrephagy through a LC3-labeled HTT inclusion bodies purification strategy followed by proteomic determination [44]. Some potent pharmacological aggrephagy inducers have also been revealed and show neuroprotective capabilities in neurodegenerative diseases, such as PD180970 and XCT 790 [45][46][47][48].…”

Section: Aggrephagymentioning

confidence: 99%

Molecular Modulators and Receptors of Selective Autophagy: Disease Implication and Identification Strategies

Wu,

Li,

2024

Int. J. Biol. Sci.

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Autophagy is a highly conserved physiological process that maintains cellular homeostasis by recycling cellular contents. Selective autophagy is based on the specificity of cargo recognition and has been implicated in various human diseases, including neurodegenerative diseases and cancer. Selective autophagy receptors and modulators play key roles in this process. Identifying these receptors and modulators and their roles is critical for understanding the machinery and physiological function of selective autophagy and providing therapeutic value for diseases. Using modern researching tools and novel screening technologies, an increasing number of selective autophagy receptors and modulators have been identified. A variety of Strategies and approaches, including protein-protein interactions (PPIs)-based identification and genome-wide screening, have been used to identify selective autophagy receptors and modulators. Understanding the strengths and challenges of these approaches not only promotes the discovery of even more such receptors and modulators but also provides a useful reference for the identification of regulatory proteins or genes involved in other cellular mechanisms. In this review, we summarize the functions, disease association, and identification strategies of selective autophagy receptors and modulators.

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Section: Aggrephagymentioning

confidence: 99%

Molecular Modulators and Receptors of Selective Autophagy: Disease Implication and Identification Strategies

Wu,

Li,

2024

Int. J. Biol. Sci.

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“…However, secondary metabolites such as rutin or quercetin are also abundant in buckwheat grains, which have anti-tumor properties, e.g., lung adenocarcenoma [1]. According to Ikari et al [2] quercetin extracted from buckwheat enhances autophagy against protein aggregation by suppressing mTORC1 activity. An experiment conducted by Wang et al, altering the diet of rats, showed that buckwheat consumption led to a higher concentration of short fatty acids (SCFA) and increased levels of Lactobacillus, Blautia, and Akkermansia strains in the gut.…”

Section: Introductionmentioning

confidence: 99%

Enzymatically Hydrolysed Common Buckwheat (Fagopyrum esculentum M.) as a Fermentable Source of Oligosaccharides and Sugars

et al. 2022

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Common buckwheat (Fagopyrum esculentum M.) is highly rich in starches and polysaccharides. Nowadays, the use of common buckwheat in brewing processes and functional product development is gaining popularity as it is gluten-free and therefore suitable for those suffering from coeliac disease. Moreover, enzyme-assisted extraction for common buckwheat releases these oligosaccharides as well as bioactive substances, which can be further used for developing new products. This research aims to compare different enzymatic hydrolysis methods and their effect on roasted common buckwheat flour. The degradation of buckwheat flour using these hydrolytic enzymes was captured using SEM. Oligosaccharide and sugar molecular mass distributions were identified using HPLC-SEC. The extract with the highest fermentable monomeric sugar content was further fermented with ancient lactic acid bacteria starters: Tibetan kefir grains and birch sap. Ferment extracts were analyzed for antimicrobial activity against ten different pathogenic bacteria. The results indicated that the incorporation of enzymes into the extraction process lead to the release of a wide variety of DP3-DP4. Furthermore, the successful fermentation of these extracts with ancient starters revealed promising antimicrobial activity against nine different pathogenic bacteria, including E. coli and L. monocytogenes. In general, common buckwheat is a suitable ingredient for developing beverages and products with high value and has high potential in pharmaceutical applications.

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Contemporary Speculations and Insightful Thoughts on Buckwheat—A Functional Pseudocereal as a Smart Biologically Active Supplement

Kurćubić,

Stajić,

Jakovljević

et al. 2024

Foods

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Today, food scientists are interested in more rational use of crops that possess desirable nutritional properties, and buckwheat is one of the functional pseudocereals that represents a rich source of bioactive compounds (BACs) and nutrients, phytochemicals, antimicrobial (AM) agents and antioxidants (AOs), which can be effectively applied in the prevention of malnutrition and celiac disease and treatment of various important health problems. There is ample evidence of the high potential of buckwheat consumption in various forms (food, dietary supplements, home remedies or alone, or in synergy with pharmaceutical drugs) with concrete benefits for human health. Contamination as well as other side-effects of all the aforementioned forms for application in different ways in humans must be seriously considered. This review paper presents an overview of the most important recent research related to buckwheat bioactive compounds (BACs), highlighting their various functions and proven positive effects on human health.

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Quercetin in Tartary Buckwheat Induces Autophagy against Protein Aggregations

Cited by 3 publications

References 40 publications

Molecular Modulators and Receptors of Selective Autophagy: Disease Implication and Identification Strategies

Molecular Modulators and Receptors of Selective Autophagy: Disease Implication and Identification Strategies

Enzymatically Hydrolysed Common Buckwheat (Fagopyrum esculentum M.) as a Fermentable Source of Oligosaccharides and Sugars

Contemporary Speculations and Insightful Thoughts on Buckwheat—A Functional Pseudocereal as a Smart Biologically Active Supplement

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