Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance

Davis, John M.; Murphy, E. Angela; Carmichael, Martin D.; Davis, Ben

doi:10.1152/ajpregu.90925.2008

Cited by 399 publications

(361 citation statements)

References 33 publications

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“…Specifically, betaine has been linked to improving muscular endurance, strength, and power (31,55) and can be found in beetroot. Likewise, the polyphenols, quercetin and resveratrol, which are found in beetroot have, in some instances, been reported to increase aerobic capacity and stimulate mitochondrial biogenesis (20,44). Although we do not rule out the potential for NO 3 Ϫ to operate synergistically with these compounds, the unchanged plasma [NO 2 Ϫ ], diastolic BP, MAP, and V O 2 response following PL supplementation suggests that NO 3 Ϫ is the key "bioactive" compound in BR.…”

Section: Experimental Considerationsmentioning

confidence: 77%

Effects of short-term dietary nitrate supplementation on blood pressure, O₂uptake kinetics, and muscle and cognitive function in older adults

Kelly

Fulford

Vanhatalo

et al. 2013

American Journal of Physiology-Regulatory, Integrative and Comp

206

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AM. Effects of shortterm dietary nitrate supplementation on blood pressure, O 2 uptake kinetics, and muscle and cognitive function in older adults. Am J Physiol Regul Integr Comp Physiol 304: R73-R83, 2013. First published November 21, 2012 doi:10.1152/ajpregu.00406.2012 Ϫ ) supplementation has been shown to reduce resting blood pressure and alter the physiological response to exercise in young adults. We investigated whether these effects might also be evident in older adults. In a double-blind, randomized, crossover study, 12 healthy, older (60 -70 yr) adults supplemented their diet for 3 days with either nitrate-rich concentrated beetroot juice (BR; 2 ϫ 70 ml/day, ϳ9.6 mmol/day NO 3 Ϫ ) or a nitrate-depleted beetroot juice placebo (PL; 2 ϫ 70 ml/day, ϳ0.01 mmol/day NO 3 Ϫ ). Before and after the intervention periods, resting blood pressure and plasma [nitrite] were measured, and subjects completed a battery of physiological and cognitive tests. Nitrate supplementation significantly increased plasma [nitrite] and reduced resting systolic (BR: 115 Ϯ 9 vs. PL: 120 Ϯ 6 mmHg; P Ͻ 0.05) and diastolic (BR: 70 Ϯ 5 vs. PL: 73 Ϯ 5 mmHg; P Ͻ 0.05) blood pressure. Nitrate supplementation resulted in a speeding of the V O2 mean response time (BR: 25 Ϯ 7 vs. PL: 28 Ϯ 7 s; P Ͻ 0.05) in the transition from standing rest to treadmill walking, although in contrast to our hypothesis, the O 2 cost of exercise remained unchanged. Functional capacity (6-min walk test), the muscle metabolic response to low-intensity exercise, brain metabolite concentrations, and cognitive function were also not altered. Dietary nitrate supplementation reduced resting blood pressure and improved V O2 kinetics during treadmill walking in healthy older adults but did not improve walking or cognitive performance. These results may have implications for the enhancement of cardiovascular health in older age.nitrate; nitrite; nitric oxide; blood pressure; exercise performance; cognitive performance; O2 uptake kinetics THE BENEFICIAL EFFECTS OF a vegetable-rich diet upon cardiovascular health (27) and longevity (79) have been well described. These positive effects have been attributed, in part, to inorganic nitrate (NO 3 Ϫ ), which is particularly rich in leafy greens and beetroot. The NO 3 Ϫ anion itself is inert, and any biological effects are likely to be the result of its conversion to the nitrite anion (NO 2 Ϫ ) in the mouth via facultative anaerobic bacteria on the surface of the tongue (25). When swallowed, NO 2 Ϫ can be further converted into nitric oxide (NO) (9), but it is clear that some NO 2 Ϫ enters the circulation. The subsequent reduction of NO 2 Ϫ to NO and other reactive nitrogen intermediates is facilitated in hypoxia (11). The production of NO via nitric oxide synthase (NOS) is impaired in hypoxia and, thus, it has been proposed that the NO 3 Ϫ -NO 2 Ϫ -NO pathway represents a complementary system for NO generation across a wide range of redox states (53). NO is an essential physiological signaling molecule with numerous functions in...

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Section: Experimental Considerationsmentioning

confidence: 77%

Effects of short-term dietary nitrate supplementation on blood pressure, O₂uptake kinetics, and muscle and cognitive function in older adults

Kelly

Fulford

Vanhatalo

et al. 2013

American Journal of Physiology-Regulatory, Integrative and Comp

206

View full text Add to dashboard Cite

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“…In mammals, flavonoids exert various biological and pharmacological effects [10]. Several studies have indicated that quercetin may have anti-inflammatory and antioxidant properties [8] due to its free radical scavenging and metal chelating activities [23]. In addition, this compound exerts a potent antioxidant effect.…”

Section: Introductionmentioning

confidence: 99%

Quercetin Improves In Vitro Development of Porcine Oocytes by Decreasing Reactive Oxygen Species Levels.

Kang

Kwon

Park

et al. 2011

Biology of Reproduction

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Quercetin is a plant-derived flavonoid found in fruits or vegetables that has antioxidant properties and acts as a free radical scavenger. We investigated the effects of quercetin on porcine oocyte nuclear maturation and embryonic development after parthenogenetic activation. We then evaluated the antioxidant activities of quercetin by measuring reactive oxygen species (ROS) levels in matured oocytes. Immature oocytes were untreated or treated with 1, 10, and 50 μg/mL quercetin during in vitro maturation (IVM). Quercetin treatment did not improve oocyte nuclear maturation, but significantly higher blastocyst rates (p ＜ 0.05) of parthenogenetically activated oocytes were achieved when the IVM medium was supplemented with an adequate concentration of quercetin (1 μg/mL). However, cleavage rates and blastocyst cell numbers were not affected. Oocytes treated with 1 or 10 μg/mL quercetin had significantly lower (p ＜ 0.05) levels of ROS than the control and group treated with the highest concentration of quercetin (50 μg/mL). Moreover, this highest concentration was detrimental to oocyte nuclear maturation and blastocyst formation. Based on our findings, we concluded that exogenous quercetin reduces ROS levels during oocyte maturation and is beneficial for subsequent embryo development.

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“…The quercetin in this investigation was combined with vitamin C and niacin to improve quercetin bioavailability, as explained in the Methods. The quercetin dose is based on animal studies showing increased mitochondrial biogenesis beginning at 12.5 mg quercetin·(kg body mass) -1 (Davis et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Quercetin with vitamin C and niacin does not affect body mass or composition

Knab

Shanely

Jin

et al. 2011

Appl. Physiol. Nutr. Metab.

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In vitro and animal data suggest that quercetin affects adipogenesis and basal metabolism; however, whether this metabolic effect translates to reductions in body mass or improvement in body composition in humans is unknown. This study investigated 12-week supplementation of 2 different doses of quercetin, combined with vitamin C and niacin, on body mass and composition in a large, heterogeneous group of adults (n = 941; 60% female, 40% male; 18-85 years of age; 45%normal body mass index, 30% overweight, 25% obese). Subjects were randomized into 3 groups, with supplements adminis-tered in double-blind fashion: Q500 = 500 mg quercetin·day-1, Q1000 = 1000 mg quercetin·day-1, and placebo. Quercetin supplements were consumed twice daily over a 12-week period, and pre-and poststudy body mass and composition meas-urements were taken in an overnight fasted state. A general linear model was used to predict change in body mass and com-position across groups with adjustment for demographic and lifestyle factors. Plasma quercetin increased in a dose-responsive manner in both Q500 and Q1000 groups relative to placebo. After adjustment for confounders, no significant dif-ferences in body mass (males interaction p value = 0.721, females p = 0.366) or body composition (males p = 0.650, fe-males p = 0.639) were found between Q500 or Q1000 groups compared with placebo. No group differences in body mass or body composition were found in a subgroup of overweight and obese subjects. High-dose quercetin supplementation (500 and 1000 mg·day-1) for 12 weeks in a large, heterogeneous group of adults did not affect body mass or composition. Abstract: In vitro and animal data suggest that quercetin affects adipogenesis and basal metabolism; however, whether this metabolic effect translates to reductions in body mass or improvement in body composition in humans is unknown. This study investigated 12-week supplementation of 2 different doses of quercetin, combined with vitamin C and niacin, on body mass and composition in a large, heterogeneous group of adults (n = 941; 60% female, 40% male; 18-85 years of age; 45% normal body mass index, 30% overweight, 25% obese). Subjects were randomized into 3 groups, with supplements administered in double-blind fashion: Q500 = 500 mg quercetin·day -1 , Q1000 = 1000 mg quercetin·day -1 , and placebo. Quercetin supplements were consumed twice daily over a 12-week period, and pre-and poststudy body mass and composition measurements were taken in an overnight fasted state. A general linear model was used to predict change in body mass and composition across groups with adjustment for demographic and lifestyle factors. Plasma quercetin increased in a doseresponsive manner in both Q500 and Q1000 groups relative to placebo. After adjustment for confounders, no significant differences in body mass (males interaction p value = 0.721, females p = 0.366) or body composition (males p = 0.650, females p = 0.639) were found between Q500 or Q1000 groups compared with placebo. No group differences in body ma...

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Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance

Cited by 399 publications

References 33 publications

Effects of short-term dietary nitrate supplementation on blood pressure, O₂uptake kinetics, and muscle and cognitive function in older adults

Effects of short-term dietary nitrate supplementation on blood pressure, O₂uptake kinetics, and muscle and cognitive function in older adults

Quercetin Improves In Vitro Development of Porcine Oocytes by Decreasing Reactive Oxygen Species Levels.

Quercetin with vitamin C and niacin does not affect body mass or composition

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Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance

Cited by 399 publications

References 33 publications

Effects of short-term dietary nitrate supplementation on blood pressure, O2uptake kinetics, and muscle and cognitive function in older adults

Effects of short-term dietary nitrate supplementation on blood pressure, O2uptake kinetics, and muscle and cognitive function in older adults

Quercetin Improves In Vitro Development of Porcine Oocytes by Decreasing Reactive Oxygen Species Levels.

Quercetin with vitamin C and niacin does not affect body mass or composition

Contact Info

Product

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Effects of short-term dietary nitrate supplementation on blood pressure, O₂uptake kinetics, and muscle and cognitive function in older adults

Effects of short-term dietary nitrate supplementation on blood pressure, O₂uptake kinetics, and muscle and cognitive function in older adults