Quercetin increases claudin-4 expression through multiple transcription factors in intestinal Caco-2 cells

Noda, Sakino; Tanabe, Soichi; Suzuki, Takuya

doi:10.1016/j.jff.2014.06.004

Cited by 20 publications

(25 citation statements)

References 10 publications

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“…Quercetin has been shown to enhance TJ barrier integrity of Caco‐2 cells at the transcriptional level, activate claudin‐4 promoter and increased the expression of claudin‐4 protein (Noda, Tanabe, & Suzuki, 2014). In addition, quercetin can inhibit expression of claudin‐2, a pore‐forming protein participating in the transport of cations and water (Amasheh et al., 2012).…”

Section: Intestinal Absorption Metabolism and Biological Effects Of Quercetinmentioning

confidence: 99%

Advance on the absorption, metabolism, and efficacy exertion of quercetin and its important derivatives

Zhang

Liang

et al. 2020

Food Frontiers

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Quercetin, a dietary flavonol, has been used as potential ingredient in food supplements to promote health. Its health effects are closely related to its bioavailability and further depend on its absorption, metabolism and excretion in vivo. Here, we systematically summarized the absorption and metabolism of quercetin in human intestine, liver, and kidney, highlighting the transport and metabolic pathways, intermediate metabolites, and circulation channels involving quercetin. The bioactivities of quercetin on theintestine, liver, and kidney were also considered. In general, except for passive diffusion, different transporters (e.g., SGLT1,OATPs, and MRPs) participate in the transport of quercetin and its metabolites across biological barriers. Quercetin undergoes phase II metabolism after absorption by the intestine and is finally excreted into bile through liver or urine through kidney. Quercetin can protect the intestinal barrier and modulate the microflora. Moreover, its antioxidant, anti-inflammatory, and anti-fibrotic activities protect the liver and kidney.

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Section: Intestinal Absorption Metabolism and Biological Effects Of Quercetinmentioning

confidence: 99%

Advance on the absorption, metabolism, and efficacy exertion of quercetin and its important derivatives

Zhang

Liang

et al. 2020

Food Frontiers

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“…To better clarify the molecular mechanisms for the ameliorating effects of CT on impaired mucosal barrier function in heat-stressed broilers, we determined the changes in the mRNA expression of tight junction proteins and found that dietary CT supplementation increased the mRNA expression of ZO-1 in the jejunum of heat-stressed broilers. Various polyphenols, such as naringenin, quercetin, kaempferol and curcumin, have been reported to regulate tight junction protein gene expression in the intestine of rodents or epithelial cell lines (Azuma, Shigeshiro, Kodama, Tanabe, & Suzuki, 2013;Noda, Tanabe, & Suzuki, 2014;Suzuki, Tanabe, & Hara, 2011;Wang et al, 2012). Song et al (2011) found that grape seed tannins enhanced expression of the tight junction protein occludin and ZO-1 in the ileum of weaned rats and in oxidative-stressed IEC-6 intestinal epithelial cells at both the mRNA and protein levels.…”

Section: T a B L E 8 Effects Of Chestnut Tannins On The Intestinal Mimentioning

confidence: 99%

Effects of chestnut tannins on intestinal morphology, barrier function, pro‐inflammatory cytokine expression, microflora and antioxidant capacity in heat‐stressed broilers

Liu

Zhao

et al. 2017

Animal Physiology Nutrition

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A study was conducted to evaluate the effects of chestnut tannins (CT) on intestinal morphology, barrier function, pro-inflammatory cytokine expression, microflora and antioxidant capacity in heat-stressed broilers. Four hundred 28-day-old male Ross 308 broilers were randomly assigned into four groups, with 10 replicates per group and 10 broilers per replicate. The broilers in the normal (NOR) group were kept at 22 ± 1°C and fed the basal diet, and each of the other three groups were treated with cyclic heat (33 ± 1°C from 0800 to 1800 and 22 ± 1°C from 1800 to 0800) and fed the basal diet with 0 (HT), 1 (CT1) or 2 (CT2) g of CT/kg of diet. The experiment lasted for 14 days. Compared with the HT group, broilers in the NOR and CT2 groups had higher (p < .05) average daily gain and villus height in the jejunum and lower serum d-lactate (p < .001) and diamine oxidase (p < .01) levels. The addition of 2 g CT/kg of diet increased the total antioxidant capacity (p < .001) and superoxide dismutase activities (p < .05) and zonula occludens-1 mRNA expression level (p < .05) and decreased the malondialdehyde concentration (p < .01) and mRNA expression levels of interleukin-6 (p < .001) and nuclear factor kappa B (p < .001) in the jejunal mucosa of heat-stressed broilers. The populations of Escherichia coli and Clostridium in the jejunum (p < .01) and caecum (p < .05) of broilers in the HT group were higher than those in the NOR and CT2 groups. In conclusion, the addition of 2 g CT/kg of diet seemed to be a feasible means of alleviating the negative effects of heat stress on the growth performance and intestinal function of broilers.

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“…19 The protective effects of quercetin, naringenin, berberine and curcumin on the integrity of tight junction have all been reported. [20][21][22][23] Gut microbiota fermented product of butyrate also enhances the intestinal barrier function through facilitating the assembly of TJ proteins. 24 Thus, bioactive compounds might be an effective strategy to combat the toxicity of DON for improved barrier functions of intestinal epithelium to protect the body against luminal bacteria and toxic materials.…”

Section: Introductionmentioning

confidence: 99%

Impact of deoxynivalenol and kaempferol on expression of tight junction proteins at different stages of Caco-2 cell proliferation and differentiation

Wang

Zhang

2019

RSC Adv.

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Quercetin increases claudin-4 expression through multiple transcription factors in intestinal Caco-2 cells

Cited by 20 publications

References 10 publications

Advance on the absorption, metabolism, and efficacy exertion of quercetin and its important derivatives

Advance on the absorption, metabolism, and efficacy exertion of quercetin and its important derivatives

Effects of chestnut tannins on intestinal morphology, barrier function, pro‐inflammatory cytokine expression, microflora and antioxidant capacity in heat‐stressed broilers

Impact of deoxynivalenol and kaempferol on expression of tight junction proteins at different stages of Caco-2 cell proliferation and differentiation

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