Quercetin inhibits depolarization-evoked glutamate release in nerve terminals from rat cerebral cortex

Lu, Cheng-Wei; Lin, Tzu-Yu; Wang, Su‐Jane

doi:10.1016/j.neuro.2013.07.009

Cited by 23 publications

(11 citation statements)

References 42 publications

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“…Another compound - quercetin - was also shown to prevent depolarization-evoked Glu release from rat synaptosomes and, comparable to luteolin, decreased presynaptic voltage-dependent Ca 2+ entry by blocking Cav2.1 and Cav2.2. Moreover, this mechanism involved the simultaneous inhibition of both PKC and PKA activities, which by phosphorylation, regulate the activity of Ca 2+ channels [ 64 ].…”

Section: Glutamatergic Signaling and Poly-phenolsmentioning

confidence: 99%

Neuroprotective Polyphenols: A Modulatory Action on Neurotransmitter Pathways

Rębas

Rzajew

Radzik

et al. 2020

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Background: Balance in neurotransmission is essential for the proper functioning of the nervous system and even a small, but prolonged disturbance, can induce the negative feedback mechanisms leading to various neuropathologies. Neurodegenerative and mood disorders such as Alzheimer’s, Parkinson’s or affective disorders are increasing medical and social problems. Among the wide spectrum of potentially destructive events, oxidative stress and disrupted metabolism of some neurotransmitters such as acetylcholine, GABA, glutamate, serotonin or dopamine appear to play a decisive role. Biologically active plant polyphenols have been shown to exert a positive impact on the function of the central nervous system by modulation of metabolism and the action of some neurotransmitters. Methods: Based on published research, the pharmacological activities of some naturally occurring polyphenols have been reviewed, with a focus on their potential therapeutic importance in the regulation of neurotransmitter systems. Results: Phytochemicals can be classified into several groups and most of them possess anticancer, antioxidative, anti-inflammatory and neuroprotective properties. They can also modulate the metabolism or action of some neurotransmitters and/or their receptors. Based on these properties, phytochemicals have been used in traditional medicine for ages, although it was focused mainly on treating symptoms. However, growing evidence indicates that polyphenols may also prevent or slow neurological diseases. Conclusion: Phytochemicals seem to be less toxic than synthetic drugs and they can be a safer alternative for currently used preparations, which exert adverse side effects. The neuroprotective actions of some plant polyphenols in the regulation of neurotransmitters metabolism, functioning of neurotransmitters receptors and antioxidative defense have potential therapeutic applications in various neurodegenerative disorders.

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Section: Glutamatergic Signaling and Poly-phenolsmentioning

confidence: 99%

Neuroprotective Polyphenols: A Modulatory Action on Neurotransmitter Pathways

Rębas

Rzajew

Radzik

et al. 2020

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“…This bioflavonoid has multiple neurobeneficial activities, such as free radical scavenging, antianxiety, neuroprotection, and cognitive enhancing effects. [191][192][193] Quercetin is chemo labile and thermo labile, which leads to lower bioavailability at the target site. 194 In addition, quercetin has poor solubility and distribution, resulting in less bioavailability to the brain.…”

Section: Nanoquercetinmentioning

confidence: 99%

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Ganesan¹,

Ko²,

Kim³

et al. 2015

IJN

107

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Oxidative stress plays a very critical role in neurodegenerative diseases, such as Parkinson’s disease (PD), which is the second most common neurodegenerative disease among elderly people worldwide. Increasing evidence has suggested that phytobioactive compounds show enhanced benefits in cell and animal models of PD. Curcumin, resveratrol, ginsenosides, quercetin, and catechin are phyto-derived bioactive compounds with important roles in the prevention and treatment of PD. However, in vivo studies suggest that their concentrations are very low to cross blood–brain barrier thereby it limits bioavailability, stability, and dissolution at target sites in the brain. To overcome these problems, nanophytomedicine with the controlled size of 1–100 nm is used to maximize efficiency in the treatment of PD. Nanosizing of phytobioactive compounds enhances the permeability into the brain with maximized efficiency and stability. Several nanodelivery techniques, including solid lipid nanoparticles, nanostructured lipid carriers, nanoliposomes, and nanoniosomes can be used for controlled delivery of nanobioactive compounds to brain. Nanocompounds, such as ginsenosides (19.9 nm) synthesized using a nanoemulsion technique, showed enhanced bioavailability in the rat brain. Here, we discuss the most recent trends and applications in PD, including 1) the role of phytobioactive compounds in reducing oxidative stress and their bioavailability; 2) the role of nanotechnology in reducing oxidative stress during PD; 3) nanodelivery systems; and 4) various nanophytobioactive compounds and their role in PD.

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“…Therefore, we prepared an animal model of chronic glaucoma and used this model to study the mechanism of quercetin’s neuroprotective effect at the presynaptic afferent level. As an important excitatory neurotransmitter of the central nervous system (CNS), glutamate plays an important role in synaptic plasticity, learning and memory (Greenamyre and Porter, 1994; Lu et al, 2013). In addition to physiological functions, glutamate in synaptic clefts has potential excitotoxicity after excessive release.…”

Section: Introductionmentioning

confidence: 99%

“…In addition to physiological functions, glutamate in synaptic clefts has potential excitotoxicity after excessive release. Excessive glutamate release is one of the molecular mechanisms responsible for many neuropathic neuron injuries, including acute traumatic stroke, seizures, and traumatic brain and spinal cord injury, and chronic neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease (Lu et al, 2013). Therefore, effective reduction of glutamate release would be considered a potential neuroprotective strategy.…”

Section: Introductionmentioning

confidence: 99%

“…In fact, some neuroprotectants currently used in human and animal brain tissue act by reducing glutamate release (Wang et al, 2004). Wang et al (2004), Lu et al (2013) provided evidence that quercetin inhibits glutamate release from purified rat cerebrocortical synaptosomes with a fluorometric assay that used exogenous glutamate dehydrogenase (GDH) and NADP + to couple the oxidative deamination of released glutamate to the generation of NADPH (McMahon and Nicholls, 1991). In addition, the total flavonoids of Oldenlandia diffusa could inhibit N -methyl-D-aspartate (NMDA) receptor-mediated currents in cultured rat hippocampal neurons (Cheng et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Quercetin Enhances Inhibitory Synaptic Inputs and Reduces Excitatory Synaptic Inputs to OFF- and ON-Type Retinal Ganglion Cells in a Chronic Glaucoma Rat Model

Zhou

Yang

et al. 2019

Front. Neurosci.

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Background Glaucoma is a neurodegenerative disease caused by excitotoxic injury of retinal ganglion cells (RGCs). In our previous model of high intraocular pressure, prepared by injecting magnetic beads into the anterior chamber, we demonstrated that an important natural dietary flavonoid compound (quercetin) can improve RGC function. However, it is unclear whether quercetin can improve the synaptic function of RGCs and how quercetin regulates synaptic transmission in rat models of chronic glaucoma. Methods A rat model of chronic glaucoma was prepared by electrocoagulation of the superior scleral vein. Electrophysiological electroretinography was used to detect the photopic negative response (PhNR). The whole-cell patch-clamp technique was used to clamp ON- and OFF- type RGCs in sections from normal retinas and from retinas that had been subjected to glaucoma for 4 weeks. Results Quercetin can reverse the decrease in PhNR amplitude caused by chronic glaucoma. The baseline frequency of miniature GABAergic inhibitory postsynaptic currents (mIPSCs) in the RGCs of glaucomatous retinal slices was lower than that of the control group. The frequencies of miniature excitatory postsynaptic currents (mEPSCs) were not significantly different between control and glaucomatous RGCs. The baseline frequencies of GABAergic mIPSCs and mEPSCs in OFF-type glaucomatous RGCs were greater than those in ON-type glaucomatous RGCs. Quercetin increased miniature GABAergic inhibitory neurotransmission to RGCs and decreased miniature glutamatergic excitatory neurotransmission, reducing the excitability of the RGCs themselves, thus alleviating the excitability of RGCs in glaucomatous slices. Conclusion Quercetin may be a promising therapeutic agent for improving RGC survival and function in glaucomatous neurodegeneration. Quercetin exerted direct protective effects on RGCs by increasing inhibitory neurotransmission and decreasing excitatory neurotransmission to RGCs, thus reducing excitotoxic damage to those cells in glaucoma.

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Quercetin inhibits depolarization-evoked glutamate release in nerve terminals from rat cerebral cortex

Cited by 23 publications

References 42 publications

Neuroprotective Polyphenols: A Modulatory Action on Neurotransmitter Pathways

Neuroprotective Polyphenols: A Modulatory Action on Neurotransmitter Pathways

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Quercetin Enhances Inhibitory Synaptic Inputs and Reduces Excitatory Synaptic Inputs to OFF- and ON-Type Retinal Ganglion Cells in a Chronic Glaucoma Rat Model

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Quercetin inhibits depolarization-evoked glutamate release in nerve terminals from rat cerebral cortex

Cited by 23 publications

References 42 publications

Neuroprotective Polyphenols: A Modulatory Action on Neurotransmitter Pathways

Neuroprotective Polyphenols: A Modulatory Action on Neurotransmitter Pathways

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson&rsquo;s disease models

Quercetin Enhances Inhibitory Synaptic Inputs and Reduces Excitatory Synaptic Inputs to OFF- and ON-Type Retinal Ganglion Cells in a Chronic Glaucoma Rat Model

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Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models