Quercetin Inhibits IL-1β-Induced Proliferation and Production of MMPs, COX-2, and PGE2 by Rheumatoid Synovial Fibroblast

Sung, Myung‐Soon; Lee, Eun‐Gyeong; Jeon, Hyun-Soon; Chae, Han-Jung; Park, Seoung Ju; Lee, Yong Chul; Yoo, Wan‐Hee

doi:10.1007/s10753-012-9473-2

Cited by 73 publications

(63 citation statements)

References 24 publications

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“…Our findings suggest that the quercetin treatment induced an anti-inflammatory response confirming previous studies where the compound decreases the production of inflammatory mediators such as iNOS, NO, COX-2, PGE 2 , and IL-1β and reduces the activation of microglia and astrocytes (30)(31)(32)(33). Furthermore, quercetin contributes to the reduction of oxidative stress, since it increases the production of antioxidant enzymes in astrocytes, microglia and neurons (34,35).…”

Section: Discussionsupporting

confidence: 90%

Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice model.

2017

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Introduction: Alzheimer's disease is the most common form of dementia. It is characterized by histopathological hallmarks such as senile plaques and neurofibrillary tangles, as well as a concomitant activation of microglial cells and astrocytes that release pro-inflammatory mediators such as IL-1β, iNOS, and COX-2, leading to neuronal dysfunction and death. Objective: To evaluate the effect of quercetin on the inflammatory response in the CA1 area of the hippocampus in a 3xTg-AD male and female mice model. Materials and methods: Animals were injected intraperitoneally with quercetin every 48 hours during three months, and we conducted histological and biochemical studies. Results: We found that in quercetin-treated 3xTg-AD mice, reactive microglia and fluorescence intensity of Aβ aggregates significantly decreased. GFAP, iNOS, and COX-2 immunoreactivity also decreased and we observed a clear tendency in the reduction of IL-1β in hippocampal lysates. Conclusion: Our work suggests an anti-inflammatory effect of quercetin in the CA1 hippocampal region of aged triple transgenic Alzheimer's disease mice.

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Section: Discussionsupporting

confidence: 90%

Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice model.

2017

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“…While IL-1β has been shown to promote proliferation in other cell types [74], [75], less is known about its mitogenic role in response to skeletal muscle injury. Following a contusion injury, the concentrations of IL-1β in rat tibialis anterior muscle were found to be ∼200 pg/mg muscle protein [76].…”

Section: Discussionmentioning

confidence: 99%

Pro-Inflammatory Mediation of Myoblast Proliferation

et al. 2014

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Skeletal muscle satellite cell function is largely dictated by the surrounding environment following injury. Immune cell infiltration dominates the extracellular space in the injured area, resulting in increased cytokine concentrations. While increased pro-inflammatory cytokine expression has been previously established in the first 3 days following injury, less is known about the time course of cytokine expression and the specific mechanisms of cytokine induced myoblast function. Therefore, the expression of IL-1β and IL-6 at several time points following injury, and their effects on myoblast proliferation, were examined. In order to do this, skeletal muscle was injured using barium chloride in mice and tissue was collected 1, 5, 10, and 28 days following injury. Mechanisms of cytokine induced proliferation were determined in cell culture using both primary and C2C12 myoblasts. It was found that there is a ∼20-fold increase in IL-1β (p≤0.05) and IL-6 (p = 0.06) expression 5 days following injury. IL-1β increased proliferation of both primary and C2C12 cells ∼25%. IL-1β stimulation also resulted in increased NF-κB activity, likely contributing to the increased proliferation. These data demonstrate for the first time that IL-1β alone can increase the mitogenic activity of primary skeletal muscle satellite cells and offer insight into the mechanisms dictating satellite cell function following injury.

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“…Nf-kB and MMP expression after treatment with these flavonoids in several recent studies ( Figure 5) (Agarwal 1982;Darwish et al 2014;Lee et al 2009;Lee et al 2012;Li et al 2015;Kubo et al 1984;Wang & Zhong 2015). …”

Section: Effects On Cytokines and Inflammatory Pathwaysmentioning

confidence: 88%