Quercetin inhibits the progression of endometrial HEC-1-A cells by regulating ferroptosis—a preliminary study

Li, Xiaoqin; Zhu, Qianqian; Ma, Meng; Guo, Haiyan

doi:10.1186/s40001-022-00934-2

Cited by 16 publications

(10 citation statements)

References 44 publications

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“…Ferroptosis is involved in a series of cancer processes, including diagnosis, prognosis, carcinogenesis, cancer resistance, and treatment of hepatocellular carcinoma (8)(9)(10), renal cell carcinoma (11)(12)(13), glioma (14)(15)(16), ovarian cancer (17)(18)(19), and so on. Furthermore, drugs such as quercetin, simvastatin and amentoflavone, as well as genes including CircRAPGEF5, protein tyrosine phosphatase non-receptor type 18 (PTPN18) and tyrosine kinase (ELK1) Oncogene participated in regulation of ferroptosis and thus played a role in EC (20)(21)(22)(23)(24)(25)(26). What's more, ferroptosis plays an important role in anti-tumor immunity.…”

Section: Introductionmentioning

confidence: 99%

Ferroptosis-related lncRNA model based on CFAP58-DT for predicting prognosis and immunocytes infiltration in endometrial cancer

Qin¹,

Qian²,

Cui³

et al. 2023

Ann Transl Med

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Background: Endometrial cancer (EC) is a kind of common gynecological tumor. Further study on the markers related to the prognosis of endometrial cancer is important for women worldwide. Methods:The Cancer Genome Atlas (TCGA) database was used to obtain the transcriptome profiling and clinical data. A model was built using packages based on R software. Immune-related databases were employed to analyze the infiltration of immunocytes. Quantitative real-time PCR (qRT-PCR), cell counting kit-8 (CCK-8), and transwell assays were utilized to investigate the role of CFAP58-DT in EC.Results: Following Cox regression analysis, 1,731 ferroptosis-related long non-coding RNA (lncRNA)were screened, and a 9-related lncRNA prognostic model was constructed. Patients were classified as highand low-risk according to their expression spectrum. Kaplan-Meier (KM) analysis showed that the prognosis of low-risk patients was poor. Operating characteristic curves, decision curve analysis, and a nomogram suggested the model could independently guide prognostic evaluation, with higher sensitivity, specificity, and efficiency than other common clinical characteristics. Gene Set Enrichment Analysis (GSEA) was conducted to determine the enriched pathways among the two groups and evaluation of the immune-infiltrating conditions were performed to help improve immune therapy. Finally, we conducted cytological studies on the model's most important indicators.Conclusions: Overall, we identified a prognostic ferroptosis-related lncRNA model based on CFAP58-DT for predicting the prognosis and immune-infiltrating conditions in EC. We concluded that the potential oncogenic role of CFAP58-DT can further guide immunotherapy and chemotherapy.

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Section: Introductionmentioning

confidence: 99%

Ferroptosis-related lncRNA model based on CFAP58-DT for predicting prognosis and immunocytes infiltration in endometrial cancer

Qin¹,

Qian²,

Cui³

et al. 2023

Ann Transl Med

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“…This implies the engagement of the NRF2/xCT pathway in promoting ferroptosis through QUE-SLC1A5 [ 135 ]. These reports are confirmed by the results of studies conducted on HEC-1-A endometrial cancer cells, in which QUE increased the intracellular level of reactive oxygen species in cells and also decreased the expression of glutathione peroxidase 4 (GPX4) [ 137 ].…”

Section: Ferroptosismentioning

confidence: 67%

Selected Flavonols Targeting Cell Death Pathways in Cancer Therapy: The Latest Achievements in Research on Apoptosis, Autophagy, Necroptosis, Pyroptosis, Ferroptosis, and Cuproptosis

Wendlocha,

Kubina,

Krzykawski

et al. 2024

Nutrients

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The complex and multi-stage processes of carcinogenesis are accompanied by a number of phenomena related to the potential involvement of various chemopreventive factors, which include, among others, compounds of natural origin such as flavonols. The use of flavonols is not only promising but also a recognized strategy for cancer treatment. The chemopreventive impact of flavonols on cancer arises from their ability to act as antioxidants, impede proliferation, promote cell death, inhibit angiogenesis, and regulate the immune system through involvement in diverse forms of cellular death. So far, the molecular mechanisms underlying the regulation of apoptosis, autophagy, necroptosis, pyroptosis, ferroptosis, and cuproptosis occurring with the participation of flavonols have remained incompletely elucidated, and the results of the studies carried out so far are ambiguous. For this reason, one of the therapeutic goals is to initiate the death of altered cells through the use of quercetin, kaempferol, myricetin, isorhamnetin, galangin, fisetin, and morin. This article offers an extensive overview of recent research on these compounds, focusing particularly on their role in combating cancer and elucidating the molecular mechanisms governing apoptosis, autophagy, necroptosis, pyroptosis, ferroptosis, and cuproptosis. Assessment of the mechanisms underlying the anticancer effects of compounds in therapy targeting various types of cell death pathways may prove useful in developing new therapeutic regimens and counteracting resistance to previously used treatments.

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“…Subsequently, we reviewed relevant papers on these six components and found that they are all associated with the treatment of endometrial cancer. Quercetin has been found to inhibit tumor proliferation by promoting ferroptosis in HEC-1-A cells . Additionally, some studies have shown that kaempferol induces G2/M phase cell cycle arrest and apoptosis, inhibits cell invasion, and upregulates the m-TOR/PI3K signaling pathway, thus contributing to the suppression of endometrial cancer .…”

Section: Discussionmentioning

confidence: 99%

“…Quercetin has been found to inhibit tumor proliferation by promoting ferroptosis in HEC-1-A cells. 44 Additionally, some studies have shown that kaempferol induces G2/M phase cell cycle arrest and apoptosis, inhibits cell invasion, and upregulates the m-TOR/PI3K signaling pathway, thus contributing to the suppression of endometrial cancer. 45 Furthermore, luteolin, 25 isorhamnetin, 46 artemetin, 25 and stigmasterol 47 have been found to inhibit the proliferation of endometrial cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Identifying the Main Components and Mechanisms of Action of Artemisia annua L. in the Treatment of Endometrial Cancer Using Network Pharmacology

Guo,

Wang,

Lei

et al. 2024

ACS Omega

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Artemisia annua L. (A. annua), a Traditional Chinese Medicine (TCM) that has been utilized in China for centuries, is known for its potential anticancer properties. However, the main components and mechanism of action of A. annua on endometrial carcinoma have not been reported. We used the TCMSP database to identify the active components of A. annua and their corresponding gene targets. We then obtained the gene targets specific to endometrial cancer from The Cancer Genome Atlas (TCGA) and GeneCards databases. The gene targets common to three databases were selected, and a "component-target" network was constructed. Protein−protein interaction (PPI) network analysis and ranking of the target proteins identified the key protein PTGS2 network analysis, and ranking of the target proteins identified the key protein PTGS2. We also screened the active components of A. annua and found that quercetin, kaempferol, luteolin, isorhamnetin, artemisin, and stigmasterol had the most targets. Molecular docking models were established for these six components with PTGS2, revealing strong binding activity for all of them. Finally, we conducted validation experiments to assess the effects of quercetin, an active component of A. annua, on endometrial cancer cells (HEC-1-A and Ishikawa cells). Our findings demonstrate that quercetin has the potential to inhibit both cell growth and migration, while also suppressing the expression of PTGS2.

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Quercetin inhibits the progression of endometrial HEC-1-A cells by regulating ferroptosis—a preliminary study

Cited by 16 publications

References 44 publications

Ferroptosis-related lncRNA model based on CFAP58-DT for predicting prognosis and immunocytes infiltration in endometrial cancer

Ferroptosis-related lncRNA model based on CFAP58-DT for predicting prognosis and immunocytes infiltration in endometrial cancer

Selected Flavonols Targeting Cell Death Pathways in Cancer Therapy: The Latest Achievements in Research on Apoptosis, Autophagy, Necroptosis, Pyroptosis, Ferroptosis, and Cuproptosis

Identifying the Main Components and Mechanisms of Action of Artemisia annua L. in the Treatment of Endometrial Cancer Using Network Pharmacology

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