Quercetin intake and the incidence of cerebrovascular disease

Abstract

Objective: To study the relation between intake of the antioxidant¯avonoid quercetin and subsequent incidence of cerebrovascular disease (CVA). Design: A cohort study carried out among 9208 Finnish men and women 15 y or more of age and initially free from cardiovascular disease. During a 28 y follow-up period in 1967 ± 1994, a total of 824 cases with CVA were diagnosed. Methods: Food consumption data were collected using a dietary history interview method covering the total habitual diet during the previous year. Results: Quercetin intake was not associated with CVA incidence. The relative risk of CVA adjusted for age, serum cholesterol, body mass index, smoking, hypertension, diabetes, geographical area, occupation and intake of beta-carotene, vitamin E, vitamin C, ®bre, various fatty acids, and energy between the highest and lowest quartiles of quercetin intake was 0.99 (95% con®dence interval (CI) 0.71 ± 1.38) for men and 0.85 (CI 0.60 ± 1.21) for women. In contrast, apples, the major source of quercetin in the study population, showed a signi®cant inverse association both in men and women, mainly due to an association with thrombotic or embolic stroke. The relative risks of thrombotic stroke after further adjustment for quercetin intake were 0.59 (CI 0.35 ± 0.99; P 0.45) and 0.61 (CI 0.33 ± 1.12: P for trend 0.02) for men and women, respectively. Conclusions: The results suggest that the intake of apples is related to a decreased risk of thrombotic stroke. This association apparently is not due to the presence of the antioxidant¯avonoid quercetin.

Triterpenoids Isolated from Apple Peels Have Potent Antiproliferative Activity and May Be Partially Responsible for Apple's Anticancer Activity

“…The molecular weights of compounds 4 and 5 were 618, and the molecular formula of C 39 H 54 O 6 was inferred from analysis of 1 H and 13 C NMR and DEPT spectra. In the 1 When the 13 C NMR was compared to that of compound 2, there were nine additional carbon signals, which were all olefinic protons and appeared at lower fields. Except for the signals of the A-ring, the carbon signals of the skeleton of compounds 2 and 4 were almost the same.…”

“…Consumption of apples has been linked to the prevention of various chronic diseases (4). Apple intake can reduce lung cancer incidence (9-10), cardiovascular disease (11), symptoms of chronic obstructive pulmonary disease (12), and the risk of thrombotic stroke (13).…”

On-line LC/UV/MS analysis of flavonols in the three apple varieties most widely cultivated in Brazil

“…The presence of compounds 1-3 and 7 is in agreement with data reported for apples grown in North America and Europe. [25][26][27][28][29] On the other hand, aglycone quercetin (8), which has been reported only once in the literature, 10 was found in the three varieties cultivated in Brazil. Alonso-Salces et al 10 proposed that this aglycone has not been reported before, probably due to its low concentration.…”

Inhibitory effect of plant phenolics on fMLP-induced intracellular calcium rise and chemiluminescence of human polymorphonuclear leukocytes and their chemotactic activityin vitro

“…Numerous studies have shown a significant beneficial effect of a fruit-and vegetable-rich diet in relation to the risk of cardiovascular disease and cancer in humans. Repeated fruit and vegetable consumption reduced the frequency of myocardial infarction and stroke (Gillman et al, 1995;Ness & Powles, 1997;Tyrovolas & Panagiotakos, 2010), the latter was particularly reduced by intake of apples or green tea (Knekt et al, 2000;Tanabe et al, 2008). A diet rich in plants was protective against certain types of neoplasms, reducing the risk of colorectal adenomas, colorectal cancer, and lung cancer (Tyrovolas & Panagiotakos, 2010;Van Duijnhoven et al, 2009).…”