Quercetin lipid nanoparticles functionalized with transferrin for Alzheimer's disease

Pinheiro, Rúben G. R.; Granja, Andreia; Loureiro, Joana A.; Pereira, Maria do Carmo; Pinheiro, Marina; Neves, Ana Rute; Reis, Salette

doi:10.1016/j.ejps.2020.105314

Cited by 128 publications

(71 citation statements)

References 57 publications

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“…In the last decades, there is a marked increase in the interest of NPs research. [62][63][64] One of the main applications of these types of compounds, nowadays, is related to biomedicine. However, little is known about their safety in chronic studies using high dosages.…”

Section: Discussionmentioning

confidence: 99%

<p>In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment</p>

Fonseca-Gomes

Loureiro

Tanqueiro

et al. 2020

IJN

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Introduction: Nanoparticles (NPs), as drug delivery systems, appear to be a promising tool for prolonged therapeutic strategies as they allow a controlled drug release over time. However, most of the studies found in the literature simply contemplate the use of a single or low number of dosages with low NPs concentrations. In the context of chronic diseases, like Alzheimer's disease, cancer or human immunodeficiency virus (HIV), where the therapeutic scheme is also chronic, studies with numerous repeated dosages are often neglected. Methods: We screened different NPs, polymeric and lipid-based, in a repeated-dose toxicity study, to evaluate the safety and tissue distribution of promising nanocarriers to be used in the treatment of long-lasting diseases. Results: After administrating 24 high concentrated doses of the selected NPs intraperitoneally (i.p.) (3 times a week for 2 months), animals have presented NPs accumulation in different tissues. However, neither toxicity, bodyweight changes nor clinical signs of disease were observed. Discussion: This work demonstrates no general adverse effects upon the studied NPs repeated-dose exposure, indicating the most promising NPs to be used in the different therapeutic circumstances, which may be useful in chronic diseases treatment.

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Section: Discussionmentioning

confidence: 99%

<p>In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment</p>

Fonseca-Gomes

Loureiro

Tanqueiro

et al. 2020

IJN

View full text Add to dashboard Cite

show abstract

“…Modern research has shown that there are many possibilities for the penetration of bioactive compounds into the brain such as blood-mediated receptor-mediated transcytosis (BBB) and coupling with transferrin receptors found on the luminal side of capillary endothelial cells of the brain. Therefore, the inclusion of QUR in transferrin-functionalized liposomes is a solution to facilitate QUR penetration into the brain (Pinheiro et al, 2020).…”

Section: Bioavailability Of Quercetinmentioning

confidence: 99%

Neuropharmacological Effects of Quercetin: A Literature-Based Review

et al. 2021

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Quercetin (QUR) is a natural bioactive flavonoid that has been lately very studied for its beneficial properties in many pathologies. Its neuroprotective effects have been demonstrated in many in vitro studies, as well as in vivo animal experiments and human trials. QUR protects the organism against neurotoxic chemicals and also can prevent the evolution and development of neuronal injury and neurodegeneration. The present work aimed to summarize the literature about the neuroprotective effect of QUR using known database sources. Besides, this review focuses on the assessment of the potential utilization of QUR as a complementary or alternative medicine for preventing and treating neurodegenerative diseases. An up-to-date search was conducted in PubMed, Science Direct and Google Scholar for published work dealing with the neuroprotective effects of QUR against neurotoxic chemicals or in neuronal injury, and in the treatment of neurodegenerative diseases. Findings suggest that QUR possess neuropharmacological protective effects in neurodegenerative brain disorders such as Alzheimer’s disease, Amyloid β peptide, Parkinson’s disease, Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis. In summary, this review emphasizes the neuroprotective effects of QUR and its advantages in being used in complementary medicine for the prevention and treatment o of different neurodegenerative diseases.

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“…Those distributions are difficult to be discerned with common techniques [ 26 ], but they usually discriminate the release profiles. Although many Solid Lipid Nanoparticles loaded with Quercetin have been already studied [ 40 , 41 , 42 , 43 , 44 , 45 ], there are not so many examples of loaded SLNs prepared with a coacervation method. In this work, this method was used to synthesize SLN loaded with Quercetin.…”

Section: Introductionmentioning

confidence: 99%

Solid Lipid Nanoparticles Produced via a Coacervation Method as Promising Carriers for Controlled Release of Quercetin

et al. 2021

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Quercetin is a poorly water-soluble flavonoid with many benefits to human health. Besides the natural food resources that may provide Quercetin, the interest in delivery systems that could enhance its bioavailability in the human body has seen growth in recent years. Promising delivery system candidates are represented by Solid Lipid Nanoparticles (SLNs) which are composed of well-tolerated compounds and provide a relatively high encapsulation efficiency and suitable controlled release. In this study, Quercetin-loaded and negatively charged Solid Lipid Nanoparticles were synthesized based on a coacervation method, using stearic acid as a core lipid and Arabic Gum as a stabilizer. Samples were qualitatively characterized by Dynamic light scattering (DLS), Zeta Potential, Surface infrared spectroscopy (FTIR-ATR), and Time of flight secondary ion mass spectrometry (ToF-SIMS). Encapsulation efficiency, drug release, and antioxidant effect against ABTS•+ were evaluated in vitro by UV–VIS spectrophotometry.

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Quercetin lipid nanoparticles functionalized with transferrin for Alzheimer's disease

Cited by 128 publications

References 57 publications

<p>In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment</p>

<p>In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment</p>

Neuropharmacological Effects of Quercetin: A Literature-Based Review

Solid Lipid Nanoparticles Produced via a Coacervation Method as Promising Carriers for Controlled Release of Quercetin

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