Quercetin-loaded solid lipid nanoparticles exhibit antitumor activity and suppress the proliferation of triple-negative MDA-MB 231 breast cancer cells: implications for invasive breast cancer treatment

Hatami, Mahdi; Kouchak, Maryam; Kheirollah, Alireza; Khorsandi, Layasadat; Rashidi, Mojtaba

doi:10.1007/s11033-023-08848-w

Cited by 9 publications

(2 citation statements)

References 49 publications

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“…Thus, inhibiting HSC activation could be beneficial in the treatment of liver fibrosis [ 25 ] . Studies have also provided evidence that flavonoids, due to their antioxidant properties, mitigate liver fibrosis progression [ 26 , 27 ] .…”

Section: Discussionmentioning

confidence: 99%

Curcumin Modulates NOX Gene Expression and ROS Production via P-Smad3C in TGF-β-Activated Hepatic Stellate Cells

Asadizadeh,

Hatami,

Salehipour Bavarsad

et al. 2024

IBJ

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Background: Liver fibrosis, associated with HSCs, occurs when a healthy liver sustains damage, thereby impairing its function. NOXs, specifically isoforms 1, 2, and 4, play a role in ROS production during hepatic injuries, resulting in fibrosis. Curcumin has shown strong potential in mitigating liver fibrosis. Our research aimed to investigate the effects of curcumin on lowering NOX and ROS levels. This compound was also studied for its effects on NOXs, ROS concentrations through the inhibition of Smad3 phosphorylation in TGF-β-activated human HSCs. Methods: MTT assay investigated the cytotoxic effects of curcumin on HSCs. The cells were activated by exposure to TGF-β (2 ng/mL) for 24 hours. After activating, the cells were treated with curcumin at 25-150 μM concentrations. After administering curcumin to the cells, we employed RT-PCR and Western blot techniques to evaluate the related gene and protein expression levels. This evaluation was primarily focused on the mRNA expression levels of NOX1 , NOX2 , NOX4 and phosphorylated Smad3C. Results: The mRNA expression level of aforesaid NOXs as well as α-SMA, collagen1-α , and ROS levels were significantly reduced following 100 μM curcumin treatment. Furthermore, curcumin significantly decreased the p-Smad3C protein level in TGF-β-activated cells, with fold changes of 3 and 2 observed at 75 and 100 μM, respectively. Conclusions: Curcumin decreased the levels of ROS and NOX , as well as the expression of α-SMA and collagen1-α . The primary mechanism for this reduction could be linked to the level of p-Smad3C. Hence, curcumin could serve as an effective therapeutic agent for liver fibrosis.

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Section: Discussionmentioning

confidence: 99%

Curcumin Modulates NOX Gene Expression and ROS Production via P-Smad3C in TGF-β-Activated Hepatic Stellate Cells

Asadizadeh,

Hatami,

Salehipour Bavarsad

et al. 2024

IBJ

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“…In addition, it activated caspases 3 and 9, enzymes that play a crucial role in initiating and executing apoptosis. The activation of poly (ADP-ribose) polymerase (PARP), another protein involved in DNA repair and cell survival, was also observed(Hatami et al, 2023a). The researchers compared the effects of QUR and QUR-SLN on various cellular processes in MDA-MB231 cells, a cell line commonly used to study triple-negative breast cancer (TNBC).…”

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confidence: 99%

Nanophytomedicine: A promising practical approach in phytotherapy

Sardarabadi,

Darvishi,

Zohrab

et al. 2024

Phytotherapy Research

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The long and rich history of herbal therapeutic nutrients is fascinating. It is incredible to think about how ancient civilizations used plants and herbs to treat various ailments and diseases. One group of bioactive phytochemicals that has gained significant attention recently is dietary polyphenols. These compounds are commonly found in a variety of fruits, vegetables, spices, nuts, drinks, legumes, and grains. Despite their incredible therapeutic properties, one challenge with polyphenols is their poor water solubility, stability, and bioavailability. This means that they are not easily absorbed by the body when consumed in essential diets. Because of structural complexity, polyphenols with high molecular weight cannot be absorbed in the small intestine and after arriving in the colon, they are metabolized by gut microbiota. However, researchers are constantly working on finding solutions to enhance the bioavailability and absorption of these compounds. This study aims to address this issue by applying nanotechnology approaches to overcome the challenges of the therapeutic application of dietary polyphenols. This combination of nanotechnology and phytochemicals could cause a completely new field called nanophytomedicine or herbal nanomedicine.

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Chitosan-enclosed SLN improved SV-induced hepatocellular cell carcinoma death by modulation of IQGAP gene expression, JNK, and HDAC activities

Harisa,

Bakheit,

Alshehri

et al. 2024

Mol Biol Rep

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Quercetin-loaded solid lipid nanoparticles exhibit antitumor activity and suppress the proliferation of triple-negative MDA-MB 231 breast cancer cells: implications for invasive breast cancer treatment

Cited by 9 publications

References 49 publications

Curcumin Modulates NOX Gene Expression and ROS Production via P-Smad3C in TGF-β-Activated Hepatic Stellate Cells

Curcumin Modulates NOX Gene Expression and ROS Production via P-Smad3C in TGF-β-Activated Hepatic Stellate Cells

Nanophytomedicine: A promising practical approach in phytotherapy

Chitosan-enclosed SLN improved SV-induced hepatocellular cell carcinoma death by modulation of IQGAP gene expression, JNK, and HDAC activities

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