Quercetin mitigates monosodium glutamate-induced excitotoxicity of the spinal cord motoneurons in aged rats via p38 MAPK inhibition

Firgany, Alaa El-Din L.; Sarhan, Nahla Reda

doi:10.1016/j.acthis.2020.151554

Cited by 19 publications

(22 citation statements)

References 67 publications

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“…Additional studies revealed that a ten-day i.p. quercetin management at a 20 mg/kg/day dosage scale could mitigate monosodium Glu-induced neurotoxicity by lowering p38MAPK, decreasing OS, and boosting GFAP transcription [ 98 ]. According to Azevedo et al [ 89 ], quercetin (25, 50, and 100 mg/kg) mitigated OS-induced degeneration by lowering LPO, which was in agreement with Liu et al [ 99 , 100 ].…”

Section: Polyphenols In Spinal Cord Injurymentioning

confidence: 99%

Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision

Islam

Bepary

Nafady

et al. 2022

Oxidative Medicine and Cellular Longevity

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A spinal cord injury (SCI) occurs when the spinal cord is deteriorated or traumatized, leading to motor and sensory functions lost even totally or partially. An imbalance within the generation of reactive oxygen species and antioxidant defense levels results in oxidative stress (OS) and neuroinflammation. After SCI, OS and occurring pathways of inflammations are significant strenuous drivers of cross-linked dysregulated pathways. It emphasizes the significance of multitarget therapy in combating SCI consequences. Polyphenols, which are secondary metabolites originating from plants, have the promise to be used as alternative therapeutic agents to treat SCI. Secondary metabolites have activity on neuroinflammatory, neuronal OS, and extrinsic axonal dysregulated pathways during the early stages of SCI. Experimental and clinical investigations have noted the possible importance of phenolic compounds as important phytochemicals in moderating upstream dysregulated OS/inflammatory signaling mediators and axonal regeneration’s extrinsic pathways after the SCI probable significance of phenolic compounds as important phytochemicals in mediating upstream dysregulated OS/inflammatory signaling mediators. Furthermore, combining polyphenols could be a way to lessen the effects of SCI.

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Section: Polyphenols In Spinal Cord Injurymentioning

confidence: 99%

Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision

Islam

Bepary

Nafady

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…These results are in line with previous studies showing evidence that quercetin reduces glutamate-induced Ca 2+ influx so that mitochondria do not release apoptotic signals that prevent neuronal cell death. 36,37 It is well known that melanocortin activity is involved in the neuroinflammatory process in the brain. The present study found that MC4R mRNA expression in the hippocampus of the stroke mice decreased compared to the sham group.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Quercetin Exerts a Protective Effect on Ischemic Stroke-induced Memory Deficits in Mice

Ardianto,

Lestari,

Primadani

et al. 2023

Journal of Pharmacology and Pharmacotherapeutics

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Objective Brain injury resulting from an ischemic stroke affects cognitive performance by disrupting the hippocampus. Several processes are involved in brain injury progression, including inflammation, glutamate excitotoxicity, and modulated brain peptide systems such as the melanocortin system. Reports show that quercetin exerts neuroprotective activity. This study investigates quercetin’s role in the cognitive function of ischemic stroke-induced mice and the possible mechanisms involved. Method ICR mice were used. The left unilateral common carotid artery occlusion was conducted for 4 h to induce an ischemic stroke in the mice. Quercetin 50, 100, and 200 mg/kg were administered to separate groups intraperitoneally for 7 days. Cognitive function was examined using the T-maze test. The hippocampal mRNA expressions of NR2A, NR2B, melanocortin 4 receptor (MC4R), pro-opiomelanocortin precursors (POMC), and nuclear factor 2 (Nrf2) were examined using reverse transcription-polymerase chain reaction. Results It was found that stroke disrupted cognitive function. Quercetin administration ameliorated cognitive impairment. Quercetin attenuated the stroke-induced decrease in MC4R mRNA expression. Moreover, quercetin suppressed the stroke-induced increase in the hippocampal mRNA expression of NR2A. Conclusion Quercetin ameliorates cognitive deficits and normalizes impaired hippocampal melanocortin and glutamatergic signaling in ischemic stroke-induced mice.

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“…In recent years, it has been revealed that quercetin could protect the injured spinal cord by decreasing oxidative. Aged rats with quercetin (20 mg/kg/d intraperitoneally for 10 days) had a decreased level of MDA and reversed the major degenerative changes, restraining OS ( Firgany and Sarhan, 2020 ). The underlying mechanism may be related to the regulation of p38 mitogen-activated protein kinase (MAPK) and activating transcription factor 2 (ATF2) pathway, thus quercetin antagonized OS.…”

Section: Therapeutic Intervention With Traditional Chinese Medicinementioning

confidence: 99%

Application of natural antioxidants from traditional Chinese medicine in the treatment of spinal cord injury

Huang

Wang²,

Li³

et al. 2022

Front. Pharmacol.

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Spinal cord injury (SCI) is a devastating central nervous system disease, caused by physical traumas. With the characteristic of high disability rate, catastrophic dysfunction, and enormous burden on the patient’s family, SCI has become a tough neurological problem without efficient treatments. Contemporarily, the pathophysiology of SCI comprises complicated and underlying mechanisms, in which oxidative stress (OS) may play a critical role in contributing to a cascade of secondary injuries. OS substantively leads to ion imbalance, lipid peroxidation, inflammatory cell infiltration, mitochondrial disorder, and neuronal dysfunction. Hence, seeking the therapeutic intervention of alleviating OS and appropriate antioxidants is an essential clinical strategy. Previous studies have reported that traditional Chinese medicine (TCM) has antioxidant, anti-inflammatory, antiapoptotic and neuroprotective effects on alleviating SCI. Notably, the antioxidant effects of some metabolites and compounds of TCM have obtained numerous verifications, suggesting a potential therapeutic strategy for SCI. This review aims at investigating the mechanisms of OS in SCI and highlighting some TCM with antioxidant capacity used in the treatment of SCI.

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Quercetin mitigates monosodium glutamate-induced excitotoxicity of the spinal cord motoneurons in aged rats via p38 MAPK inhibition

Cited by 19 publications

References 67 publications

Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision

Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision

Quercetin Exerts a Protective Effect on Ischemic Stroke-induced Memory Deficits in Mice

Application of natural antioxidants from traditional Chinese medicine in the treatment of spinal cord injury

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