Quercetin protects the impairment of memory and anxiogenic-like behavior in rats exposed to cadmium: Possible involvement of the acetylcholinesterase and Na+,K+-ATPase activities

Abdalla, Fátima Husein; Schmatz, Roberta; Cardoso, Andréia Machado; Carvalho, Fabiano B.; Baldissarelli, Jucimara; Oliveira, Juliane Sorraila de; Rosa, Michelle Melgarejo da; Nunes, Matheus A.G.; Rubin, Maribel Antonello; Cruz, Ivana Beatrice Mânica da; Barbisan, Fernanda; Dressler, Valderi L.; Pereira, Luciane Belmonte; Schetinger, Maria Rosa Chitolina; Morsch, Vera Maria; Gonçalves, Jamile Fabbrin; Mazzanti, Cinthia M.

doi:10.1016/j.physbeh.2014.06.008

Cited by 103 publications

(47 citation statements)

References 98 publications

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“…Double‐strand DNA fragmentation was found to be increased in arthritic rats indicating cytotoxicity, which was likely due to oxidative damage and apoptosis. Treatment with quercetin reverted these results, in agreement with the observations of Abdalla et al and Lovato et al from studies on murine models of chemical cytotoxicity. This effect may be associated with the antioxidant action of quercetin, due to the presence of the O‐dihydroxyl structure at the 3′ and 4′ positions in the B‐ring referred to as the catechol group whose configuration confers high scavenging capacity …”

Section: Discussionsupporting

confidence: 91%

Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis

Saccol

Silveira

Manzoni

et al. 2019

J of Cellular Biochemistry

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Rheumatoid arthritis is a highly debilitating inflammatory autoimmune disease which is characterized by joint destruction. The present study sought to investigate the effect of quercetin in rats with complete Freund's adjuvant‐induced arthritis. Animals were divided into control/saline, control/quercetin (5 mg/kg, 25 mg/kg, and 50 mg/kg) arthritis/saline, and arthritis/quercetin (5 mg/kg, 25 mg/kg, and 50 mg/kg); the treatments were administered for 45 days. Biochemical, oxidative stress, genotoxicity, and cytotoxicity parameters were evaluated. All doses of quercetin reduced the levels of aspartate aminotransferase, thiobarbituric acid‐reactive substances, and reactive oxygen species; however, only treatment with 25 or 50 mg/kg increased catalase activity. Total thiol and reduced glutathione levels were not significantly affected by the induction nor by the treatments. Genotoxicity assessed by DNA damage, and cytotoxicity through picogreen assay, decreased after treatments with quercetin. Our results present evidence of the antioxidant, cytoprotective, genoprotective and hepatoprotective, and effects of quercetin, demonstrating its potential as a candidate for coadjuvant therapy.

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Section: Discussionsupporting

confidence: 91%

Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis

Saccol

Silveira

Manzoni

et al. 2019

J of Cellular Biochemistry

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“…Cd administration significantly decreased TSH content and increased protein carbonylation in the hippocampus. This result confirmed those of previous studies, which showed that Cd administration significantly increased ROS-mediated reactions in the brain, including the hippocampus [30], and kidney [31]. We also estimated lipid peroxidation by measuring MDA level, which is a major oxidation product of peroxidized polyunsaturated fatty acids [32].…”

Section: Discussionsupporting

confidence: 89%

Dendropanax morbifera Léveille extract facilitates cadmium excretion and prevents oxidative damage in the hippocampus by increasing antioxidant levels in cadmium-exposed rats

Kim

Yoo

et al. 2014

BMC Complement Altern Med

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BackgroundDendropanax morbifera Léveille is used in herbal medicine as a cancer treatment. In this study, we investigated the effects of Dendropanax morbifera stem extract (DMS) on cadmium (Cd) excretion from the blood and kidney and brain tissues of rats exposed to cadmium, as well as the effects of DMS on oxidative stress and antioxidant levels in the hippocampus after Cd exposure.MethodsSeven-week-old Sprague-Dawley rats were exposed to 2 mg/kg of cadmium by intragastric gavage and were orally administered 100 mg/kg of DMS for 4 weeks. Animals were sacrificed and Cd determination was performed using inductively coupled plasma mass spectrometry. In addition, the effects of Cd and/or DMS on oxidative stress were assayed by measuring reactive oxygen species production, protein carbonyl modification, lipid peroxidation levels, and antioxidant levels in hippocampal homogenates.ResultsExposure to Cd significantly increased Cd content in the blood, kidneys, and hippocampi. DMS treatment significantly reduced Cd content in the blood and kidneys, but not in the hippocampi. Exposure to Cd significantly increased reactive oxygen species production, protein carbonyl modification, lipid peroxidation, total sulfhydryl content, reduced glutathione content, and glutathione reductase activity. In contrast, Cu, Zn-superoxide dismutase (SOD1), catalase (CAT), glutathione peroxidase (GPx), and glutathione-S-transferase (GST) activity in the hippocampus were significantly decreased after exposure to Cd, and administration of DMS significantly inhibited these Cd-induced changes.ConclusionThese results indicate that DMS facilitates cadmium excretion from the kidneys, reduces cadmium-induced oxidative stress in the hippocampus, and modulates SOD1, CAT, GPx, and glutathione-S-transferase activities.

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“…These results suggest a that the quercetin-treated 3xTg-AD mice exhibited reduced anxiety or a “risk assessment” behavior when they visit the open arms of the maze (Walf and Frye, 2007) compared to the vehicle-treated 3xTg-AD mice, which may exhibit a higher level of anxiety than control mice (Gimenez-Llort et al, 2007; Sterniczuk et al, 2010). In fact, the flavonol quercetin exerts antidepressant and/or anxiolytic effects based on several studies of oral administration of quercetin to both rats (Abdalla et al, 2014; Merzoug et al, 2014; Priprem et al, 2008) and C57BL/6 mice (Vissiennon et al, 2012). Furthermore, quercetin has been demonstrated to act as a monoamine oxidase inhibitor (Chimenti et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice

et al. 2015

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Alzheimer’s disease (AD) is the most common senile dementia in the world. Although important progress has been made in understanding the pathogenesis of AD, current therapeutic approaches provide only modest symptomatic relief. In this study, we evaluated the neuroprotective effect of quercetin (25 mg/kg) administration via i.p. injection every 48 hours for 3 months on aged (21–24 months old) triple transgenic AD model (3xTg-AD) mice. Our data show that quercetin decreases extracellular β-amyloidosis, tauopathy, astrogliosis and microgliosis in the hippocampus and the amygdala. These results were supported by a significant reduction in the paired helical filament (PHF), β-amyloid (βA) 1–40 and βA 1–42 levels and a decrease in BACE1-mediated cleavage of APP (into CTFβ). Additionally, quercetin induced improved performance on learning and spatial memory tasks and greater risk assessment behavior based on the elevated plus maze test. Together, these findings suggest that quercetin reverses histological hallmarks of AD and protects cognitive and emotional function in aged 3xTg-AD mice.

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Quercetin protects the impairment of memory and anxiogenic-like behavior in rats exposed to cadmium: Possible involvement of the acetylcholinesterase and Na+,K+-ATPase activities

Cited by 103 publications

References 98 publications

Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis

Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis

Dendropanax morbifera Léveille extract facilitates cadmium excretion and prevents oxidative damage in the hippocampus by increasing antioxidant levels in cadmium-exposed rats

The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice

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